Characteristics of urinary sodium excretion in patients with chronic kidney disease in Jiangsu, China

Abstract The current study aimed to assess the dietary salt intake in patients with CKD in Jiangsu province and investigate the relationship of urinary sodium excretion with blood pressure. A total of 800 patients with CKD stages 1–4 were recruited. All enrolled patients were asked to collect comple...

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Main Authors: Lianqin Sun, Suyan Duan, Chenyan Zuo, Zhiying Sun, Guangyan Nie, Chengning Zhang, Ming Zeng, Bin Sun, Yanggang Yuan, Ningning Wang, Huijuan Mao, Changying Xing, Bo Zhang
Formato: Artigo
Idioma:English
Publicado em: Wiley 2021-07-01
Colecção:The Journal of Clinical Hypertension
Assuntos:
Acesso em linha:https://doi.org/10.1111/jch.14307
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author Lianqin Sun
Suyan Duan
Chenyan Zuo
Zhiying Sun
Guangyan Nie
Chengning Zhang
Ming Zeng
Bin Sun
Yanggang Yuan
Ningning Wang
Huijuan Mao
Changying Xing
Bo Zhang
author_facet Lianqin Sun
Suyan Duan
Chenyan Zuo
Zhiying Sun
Guangyan Nie
Chengning Zhang
Ming Zeng
Bin Sun
Yanggang Yuan
Ningning Wang
Huijuan Mao
Changying Xing
Bo Zhang
author_sort Lianqin Sun
collection DOAJ
description Abstract The current study aimed to assess the dietary salt intake in patients with CKD in Jiangsu province and investigate the relationship of urinary sodium excretion with blood pressure. A total of 800 patients with CKD stages 1–4 were recruited. All enrolled patients were asked to collect complete 24‐h urine specimen. At the same time, patient's demographic and laboratory data were recorded. The mean age was 47.45 ± 15.25 years old, including 423 men and 377 women. There was no significant difference in urinary sodium excretion among different stages of CKD (p = .748). This study revealed that the median urinary sodium excretion of all patients was 127.20 mmol/d (IQR 91.03–172.06), corresponding to a salt intake of 7.4 g/d. Among them, only 167 (20.9%) cases had salt intake <5 g/d. Moreover, urinary sodium excretion in overweight group and obese group was higher than that in normal weight group (p = .001, p ˂ .001). Likewise, urinary sodium excretion in men was higher than that in women (p ˂ .001). Spearman correlation analysis indicated that urinary sodium excretion positively correlated with urinary protein excretion (r = .178, p ˂ .001), SBP (r = .109, p = .002), and DBP (r = .086, p = .015). After adjusting for age, gender, BMI, eGFR, urinary protein excretion, and history of taking antihypertensive drug, multivariate linear regression demonstrated that higher level of urinary sodium excretion associated with increased level of SBP, DBP, and MAP (β = 0.020, p = .049; β = 0.015, p = .040; β = 0.016, p = .025, respectively). In conclusion, the dietary salt intake in CKD patients, especially in male, overweight and obese subjects, remains high in Jiangsu province. It is vital to decline salt intake to control blood pressure in Jiangsu patients with CKD.
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spelling doaj.art-e66d94e0109948a6b3cb1535862bb0412023-10-30T13:30:36ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762021-07-012371372137910.1111/jch.14307Characteristics of urinary sodium excretion in patients with chronic kidney disease in Jiangsu, ChinaLianqin Sun0Suyan Duan1Chenyan Zuo2Zhiying Sun3Guangyan Nie4Chengning Zhang5Ming Zeng6Bin Sun7Yanggang Yuan8Ningning Wang9Huijuan Mao10Changying Xing11Bo Zhang12Department of Nephrology Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University Nanjing Medical University Nanjing ChinaDepartment of Nephrology Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University Nanjing Medical University Nanjing ChinaDepartment of Gastroenterology Lianyungang No 1 People's Hospital Lianyungang ChinaDepartment of Nephrology Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University Nanjing Medical University Nanjing ChinaDepartment of Nephrology Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University Nanjing Medical University Nanjing ChinaDepartment of Nephrology Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University Nanjing Medical University Nanjing ChinaDepartment of Nephrology Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University Nanjing Medical University Nanjing ChinaDepartment of Nephrology Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University Nanjing Medical University Nanjing ChinaDepartment of Nephrology Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University Nanjing Medical University Nanjing ChinaDepartment of Nephrology Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University Nanjing Medical University Nanjing ChinaDepartment of Nephrology Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University Nanjing Medical University Nanjing ChinaDepartment of Nephrology Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University Nanjing Medical University Nanjing ChinaDepartment of Nephrology Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University Nanjing Medical University Nanjing ChinaAbstract The current study aimed to assess the dietary salt intake in patients with CKD in Jiangsu province and investigate the relationship of urinary sodium excretion with blood pressure. A total of 800 patients with CKD stages 1–4 were recruited. All enrolled patients were asked to collect complete 24‐h urine specimen. At the same time, patient's demographic and laboratory data were recorded. The mean age was 47.45 ± 15.25 years old, including 423 men and 377 women. There was no significant difference in urinary sodium excretion among different stages of CKD (p = .748). This study revealed that the median urinary sodium excretion of all patients was 127.20 mmol/d (IQR 91.03–172.06), corresponding to a salt intake of 7.4 g/d. Among them, only 167 (20.9%) cases had salt intake <5 g/d. Moreover, urinary sodium excretion in overweight group and obese group was higher than that in normal weight group (p = .001, p ˂ .001). Likewise, urinary sodium excretion in men was higher than that in women (p ˂ .001). Spearman correlation analysis indicated that urinary sodium excretion positively correlated with urinary protein excretion (r = .178, p ˂ .001), SBP (r = .109, p = .002), and DBP (r = .086, p = .015). After adjusting for age, gender, BMI, eGFR, urinary protein excretion, and history of taking antihypertensive drug, multivariate linear regression demonstrated that higher level of urinary sodium excretion associated with increased level of SBP, DBP, and MAP (β = 0.020, p = .049; β = 0.015, p = .040; β = 0.016, p = .025, respectively). In conclusion, the dietary salt intake in CKD patients, especially in male, overweight and obese subjects, remains high in Jiangsu province. It is vital to decline salt intake to control blood pressure in Jiangsu patients with CKD.https://doi.org/10.1111/jch.14307blood pressurechronic kidney diseasesalt intakeurinary sodium excretion
spellingShingle Lianqin Sun
Suyan Duan
Chenyan Zuo
Zhiying Sun
Guangyan Nie
Chengning Zhang
Ming Zeng
Bin Sun
Yanggang Yuan
Ningning Wang
Huijuan Mao
Changying Xing
Bo Zhang
Characteristics of urinary sodium excretion in patients with chronic kidney disease in Jiangsu, China
The Journal of Clinical Hypertension
blood pressure
chronic kidney disease
salt intake
urinary sodium excretion
title Characteristics of urinary sodium excretion in patients with chronic kidney disease in Jiangsu, China
title_full Characteristics of urinary sodium excretion in patients with chronic kidney disease in Jiangsu, China
title_fullStr Characteristics of urinary sodium excretion in patients with chronic kidney disease in Jiangsu, China
title_full_unstemmed Characteristics of urinary sodium excretion in patients with chronic kidney disease in Jiangsu, China
title_short Characteristics of urinary sodium excretion in patients with chronic kidney disease in Jiangsu, China
title_sort characteristics of urinary sodium excretion in patients with chronic kidney disease in jiangsu china
topic blood pressure
chronic kidney disease
salt intake
urinary sodium excretion
url https://doi.org/10.1111/jch.14307
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