Urinary tract infection inducing stones: some clinical and chemical data
Most papers on kidney stones arising from infection concentrate on the mineral struvite. In this contribution, we would like to call attention to other mineral phases such as highly carbonated calcium phosphate apatite, ammonium urate, and whitlockite, by presenting clinical and chemical data. We st...
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| Format: | Article |
| Language: | English |
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Académie des sciences
2022-03-01
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| Series: | Comptes Rendus. Chimie |
| Subjects: | |
| Online Access: | https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.159/ |
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| author | Daudon, Michel Petay, Margaux Vimont, Sophie Deniset, Ariane Tielens, Frederik Haymann, Jean-Philippe Letavernier, Emmanuel Frochot, Vincent Bazin, Dominique |
| author_facet | Daudon, Michel Petay, Margaux Vimont, Sophie Deniset, Ariane Tielens, Frederik Haymann, Jean-Philippe Letavernier, Emmanuel Frochot, Vincent Bazin, Dominique |
| author_sort | Daudon, Michel |
| collection | DOAJ |
| description | Most papers on kidney stones arising from infection concentrate on the mineral struvite. In this contribution, we would like to call attention to other mineral phases such as highly carbonated calcium phosphate apatite, ammonium urate, and whitlockite, by presenting clinical and chemical data. We start with epidemiological data which emphasize the increase in the prevalence of kidney stones related to infection. Then we present a statistical analysis of more than 85,000 stones which have been analysed at the Laboratoire des Lithiases of Assistance Publique-Hôpitaux de Paris which gives insights regarding the link between urinary tract infection and struvite, carbonated calcium phosphate apatite (carbapatite), and also surprisingly whitlockite. Some information regarding the pathogenesis of kidney stones linked to infection, the nature of the bacteria which have been identified, and the approach to precisely analyse infrared spectra to identify struvite, carbapatite, and whitlockite, conclude this first part. To complete this clinical description, we describe the crystallographic structure and the chemistry of three relevant compounds namely carbonated calcium phosphate, struvite, and whitlockite. To conclude this second part, the dependence of crystallite morphology of struvite on pH and on the presence, or absence, of bacteria, is described. Based on clinical and chemical data, it is becoming clear that struvite is not the only mineral intimately related to renal infectious processes, but that whitlockite and carbapatite with a high carbonation rate are strongly associated with urinary tract infection as well. |
| first_indexed | 2024-03-11T16:14:43Z |
| format | Article |
| id | doaj.art-e6737e8302bd4cc587ca17cfbad04086 |
| institution | Directory Open Access Journal |
| issn | 1878-1543 |
| language | English |
| last_indexed | 2024-03-11T16:14:43Z |
| publishDate | 2022-03-01 |
| publisher | Académie des sciences |
| record_format | Article |
| series | Comptes Rendus. Chimie |
| spelling | doaj.art-e6737e8302bd4cc587ca17cfbad040862023-10-24T14:23:18ZengAcadémie des sciencesComptes Rendus. Chimie1878-15432022-03-0125S131533410.5802/crchim.15910.5802/crchim.159Urinary tract infection inducing stones: some clinical and chemical dataDaudon, Michel0https://orcid.org/0000-0001-9844-9823Petay, Margaux1Vimont, Sophie2Deniset, Ariane3https://orcid.org/0000-0002-1923-4988Tielens, Frederik4https://orcid.org/0000-0002-6760-6176Haymann, Jean-Philippe5https://orcid.org/0000-0002-2756-2287Letavernier, Emmanuel6https://orcid.org/0000-0002-6053-8975Frochot, Vincent7Bazin, Dominique8https://orcid.org/0000-0002-5112-9061Explorations fonctionnelles multidisciplinaires, AP-HP, Hôpital Tenon, Paris, France; Sorbonne Universités, UPMC Univ Paris 6, UMR S 1155, Paris, France; INSERM, UMR S 1155, Paris, FranceInstitut de Chimie Physique, UMR CNRS 8000, Bâtiment 350, Université Paris Saclay, 91405 Orsay cedex, FranceSorbonne Universités, UPMC Univ Paris 6, UMR S 1155, Paris, France; INSERM, UMR S 1155, Paris, France; Département de bactériologie, AP-HP, Hôpital Saint-Antoine, Paris, FranceInstitut de Chimie Physique, UMR CNRS 8000, Bâtiment 350, Université Paris Saclay, 91405 Orsay cedex, FranceEenheid Algemene Chemie (ALGC) – Materials Modelling Group, Vrije Universiteit Brussel (VUB), Pleinlaan 2, 1050 Brussel, BelgiumExplorations fonctionnelles multidisciplinaires, AP-HP, Hôpital Tenon, Paris, France; Sorbonne Universités, UPMC Univ Paris 6, UMR S 1155, Paris, France; INSERM, UMR S 1155, Paris, FranceExplorations fonctionnelles multidisciplinaires, AP-HP, Hôpital Tenon, Paris, France; Sorbonne Universités, UPMC Univ Paris 6, UMR S 1155, Paris, France; INSERM, UMR S 1155, Paris, FranceExplorations fonctionnelles multidisciplinaires, AP-HP, Hôpital Tenon, Paris, France; Sorbonne Universités, UPMC Univ Paris 6, UMR S 1155, Paris, France; INSERM, UMR S 1155, Paris, FranceInstitut de Chimie Physique, UMR CNRS 8000, Bâtiment 350, Université Paris Saclay, 91405 Orsay cedex, France; Laboratoire de Physique des Solides, UMR CNRS 8502, Bâtiment 510, Université Paris Saclay, 91405 Orsay cedex, FranceMost papers on kidney stones arising from infection concentrate on the mineral struvite. In this contribution, we would like to call attention to other mineral phases such as highly carbonated calcium phosphate apatite, ammonium urate, and whitlockite, by presenting clinical and chemical data. We start with epidemiological data which emphasize the increase in the prevalence of kidney stones related to infection. Then we present a statistical analysis of more than 85,000 stones which have been analysed at the Laboratoire des Lithiases of Assistance Publique-Hôpitaux de Paris which gives insights regarding the link between urinary tract infection and struvite, carbonated calcium phosphate apatite (carbapatite), and also surprisingly whitlockite. Some information regarding the pathogenesis of kidney stones linked to infection, the nature of the bacteria which have been identified, and the approach to precisely analyse infrared spectra to identify struvite, carbapatite, and whitlockite, conclude this first part. To complete this clinical description, we describe the crystallographic structure and the chemistry of three relevant compounds namely carbonated calcium phosphate, struvite, and whitlockite. To conclude this second part, the dependence of crystallite morphology of struvite on pH and on the presence, or absence, of bacteria, is described. Based on clinical and chemical data, it is becoming clear that struvite is not the only mineral intimately related to renal infectious processes, but that whitlockite and carbapatite with a high carbonation rate are strongly associated with urinary tract infection as well.https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.159/Infection-induced calculiStruviteWhitlockiteAmorphous carbonated calcium phosphateCarbapatiteCarbonation rateUrease-splitting bacteria |
| spellingShingle | Daudon, Michel Petay, Margaux Vimont, Sophie Deniset, Ariane Tielens, Frederik Haymann, Jean-Philippe Letavernier, Emmanuel Frochot, Vincent Bazin, Dominique Urinary tract infection inducing stones: some clinical and chemical data Comptes Rendus. Chimie Infection-induced calculi Struvite Whitlockite Amorphous carbonated calcium phosphate Carbapatite Carbonation rate Urease-splitting bacteria |
| title | Urinary tract infection inducing stones: some clinical and chemical data |
| title_full | Urinary tract infection inducing stones: some clinical and chemical data |
| title_fullStr | Urinary tract infection inducing stones: some clinical and chemical data |
| title_full_unstemmed | Urinary tract infection inducing stones: some clinical and chemical data |
| title_short | Urinary tract infection inducing stones: some clinical and chemical data |
| title_sort | urinary tract infection inducing stones some clinical and chemical data |
| topic | Infection-induced calculi Struvite Whitlockite Amorphous carbonated calcium phosphate Carbapatite Carbonation rate Urease-splitting bacteria |
| url | https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.159/ |
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