Altered Brain Function in Young HIV Patients with Syphilis Infection: A Voxel-Wise Degree Centrality Analysis
Xiao-Dong Zhang,1,2 Guang-Xue Liu,3 Xiao-Yue Wang,2 Xiao-Jie Huang,4 Jing-Li Li,1 Rui-Li Li,2 Hong-Jun Li2 1Department of Radiology, Tianjin First Central Hospital, Tianjin 300192, People’s Republic of China; 2Department of Radiology, Beijing Youan Hospital, Capital Medical University, Bei...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2020-03-01
|
| Series: | Infection and Drug Resistance |
| Subjects: | |
| Online Access: | https://www.dovepress.com/altered-brain-function-in-young-hiv-patients-with-syphilis-infection-a-peer-reviewed-article-IDR |
| _version_ | 1818132367724773376 |
|---|---|
| author | Zhang XD Liu GX Wang XY Huang XJ Li JL Li RL Li HJ |
| author_facet | Zhang XD Liu GX Wang XY Huang XJ Li JL Li RL Li HJ |
| author_sort | Zhang XD |
| collection | DOAJ |
| description | Xiao-Dong Zhang,1,2 Guang-Xue Liu,3 Xiao-Yue Wang,2 Xiao-Jie Huang,4 Jing-Li Li,1 Rui-Li Li,2 Hong-Jun Li2 1Department of Radiology, Tianjin First Central Hospital, Tianjin 300192, People’s Republic of China; 2Department of Radiology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, People’s Republic of China; 3Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, People’s Republic of China; 4Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing 100069, People’s Republic of ChinaCorrespondence: Rui-Li Li; Hong-Jun LiDepartment of Radiology, Beijing Youan Hospital, Capital Medical University, No. 8, Xi Tou Tiao, Youanmen Wai, Fengtai District, Beijing 100069, People’s Republic of ChinaTel +86 010 83997337Fax +86 010 63051182Email 1985lrli@sina.com; lihongjun00113@sina.comObjective: This study assessed the possible effect of syphilis co-infection in the brain function in young HIV patients by using voxel-wise degree centrality (DC) analysis.Methods: Forty-four syphilis-co-infected HIV patients (HIV+/syphilis+), 45 HIV patients without syphilis history (HIV+/syphilis-) and 43 matched healthy controls (HC) underwent resting-state fMRI examinations. Laboratory tests and a battery of neuropsychological tests were performed before each MRI examination. One-way ANOVA was used to compare the differences of DC among the three groups. The correlations between MRI metrics and laboratory/neuropsychological tests in each patient’s group were performed by Pearson correlation analysis.Results: Compared with HIV+/syphilis-, worse performance in complex motor skills was found in HIV+/syphilis+. Compared with HC, HIV+/syphilis+ and HIV+/syphilis- groups showed attenuated DC in the right orbital frontal cortex and increased DC in the left parietal/temporal cortex. Besides, we also found increased DC in the left inferior frontal cortex and bilateral posterior cingulated cortex/precuneus in HIV+/syphilis+ compared with HC. Moreover, compared with HIV+/syphilis-, HIV+/syphilis+ displayed decreased DC in the left middle occipital cortex. Additionally, in HIV+/syphilis+ group, the mean z value of DC was correlated to the CD4+ cell counts and the learning and delayed recall score.Conclusion: Syphilis co-infection might be related to more brain functional reorganization in young HIV patients which could be reflected by DC value.Keywords: syphilis, HIV, functional connectivity, fMRI, brain |
| first_indexed | 2024-12-11T08:35:42Z |
| format | Article |
| id | doaj.art-e6776bfaec584d628436261d54804313 |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-12-11T08:35:42Z |
| publishDate | 2020-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-e6776bfaec584d628436261d548043132022-12-22T01:14:21ZengDove Medical PressInfection and Drug Resistance1178-69732020-03-01Volume 1382383352430Altered Brain Function in Young HIV Patients with Syphilis Infection: A Voxel-Wise Degree Centrality AnalysisZhang XDLiu GXWang XYHuang XJLi JLLi RLLi HJXiao-Dong Zhang,1,2 Guang-Xue Liu,3 Xiao-Yue Wang,2 Xiao-Jie Huang,4 Jing-Li Li,1 Rui-Li Li,2 Hong-Jun Li2 1Department of Radiology, Tianjin First Central Hospital, Tianjin 300192, People’s Republic of China; 2Department of Radiology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, People’s Republic of China; 3Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, People’s Republic of China; 4Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing 100069, People’s Republic of ChinaCorrespondence: Rui-Li Li; Hong-Jun LiDepartment of Radiology, Beijing Youan Hospital, Capital Medical University, No. 8, Xi Tou Tiao, Youanmen Wai, Fengtai District, Beijing 100069, People’s Republic of ChinaTel +86 010 83997337Fax +86 010 63051182Email 1985lrli@sina.com; lihongjun00113@sina.comObjective: This study assessed the possible effect of syphilis co-infection in the brain function in young HIV patients by using voxel-wise degree centrality (DC) analysis.Methods: Forty-four syphilis-co-infected HIV patients (HIV+/syphilis+), 45 HIV patients without syphilis history (HIV+/syphilis-) and 43 matched healthy controls (HC) underwent resting-state fMRI examinations. Laboratory tests and a battery of neuropsychological tests were performed before each MRI examination. One-way ANOVA was used to compare the differences of DC among the three groups. The correlations between MRI metrics and laboratory/neuropsychological tests in each patient’s group were performed by Pearson correlation analysis.Results: Compared with HIV+/syphilis-, worse performance in complex motor skills was found in HIV+/syphilis+. Compared with HC, HIV+/syphilis+ and HIV+/syphilis- groups showed attenuated DC in the right orbital frontal cortex and increased DC in the left parietal/temporal cortex. Besides, we also found increased DC in the left inferior frontal cortex and bilateral posterior cingulated cortex/precuneus in HIV+/syphilis+ compared with HC. Moreover, compared with HIV+/syphilis-, HIV+/syphilis+ displayed decreased DC in the left middle occipital cortex. Additionally, in HIV+/syphilis+ group, the mean z value of DC was correlated to the CD4+ cell counts and the learning and delayed recall score.Conclusion: Syphilis co-infection might be related to more brain functional reorganization in young HIV patients which could be reflected by DC value.Keywords: syphilis, HIV, functional connectivity, fMRI, brainhttps://www.dovepress.com/altered-brain-function-in-young-hiv-patients-with-syphilis-infection-a-peer-reviewed-article-IDRsyphilishivfunctional connectivityfmribrain |
| spellingShingle | Zhang XD Liu GX Wang XY Huang XJ Li JL Li RL Li HJ Altered Brain Function in Young HIV Patients with Syphilis Infection: A Voxel-Wise Degree Centrality Analysis Infection and Drug Resistance syphilis hiv functional connectivity fmri brain |
| title | Altered Brain Function in Young HIV Patients with Syphilis Infection: A Voxel-Wise Degree Centrality Analysis |
| title_full | Altered Brain Function in Young HIV Patients with Syphilis Infection: A Voxel-Wise Degree Centrality Analysis |
| title_fullStr | Altered Brain Function in Young HIV Patients with Syphilis Infection: A Voxel-Wise Degree Centrality Analysis |
| title_full_unstemmed | Altered Brain Function in Young HIV Patients with Syphilis Infection: A Voxel-Wise Degree Centrality Analysis |
| title_short | Altered Brain Function in Young HIV Patients with Syphilis Infection: A Voxel-Wise Degree Centrality Analysis |
| title_sort | altered brain function in young hiv patients with syphilis infection a voxel wise degree centrality analysis |
| topic | syphilis hiv functional connectivity fmri brain |
| url | https://www.dovepress.com/altered-brain-function-in-young-hiv-patients-with-syphilis-infection-a-peer-reviewed-article-IDR |
| work_keys_str_mv | AT zhangxd alteredbrainfunctioninyounghivpatientswithsyphilisinfectionavoxelwisedegreecentralityanalysis AT liugx alteredbrainfunctioninyounghivpatientswithsyphilisinfectionavoxelwisedegreecentralityanalysis AT wangxy alteredbrainfunctioninyounghivpatientswithsyphilisinfectionavoxelwisedegreecentralityanalysis AT huangxj alteredbrainfunctioninyounghivpatientswithsyphilisinfectionavoxelwisedegreecentralityanalysis AT lijl alteredbrainfunctioninyounghivpatientswithsyphilisinfectionavoxelwisedegreecentralityanalysis AT lirl alteredbrainfunctioninyounghivpatientswithsyphilisinfectionavoxelwisedegreecentralityanalysis AT lihj alteredbrainfunctioninyounghivpatientswithsyphilisinfectionavoxelwisedegreecentralityanalysis |