Disease Specific Autoantibodies in Idiopathic Inflammatory Myopathies
Idiopathic inflammatory myopathies represent still a diagnostic and therapeutic challenge in different disciplines including neurology, rheumatology, and dermatology. In recent years, the spectrum of idiopathic inflammatory myopathies has been significantly extended and the different manifestations...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-05-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2019.00438/full |
| _version_ | 1818916574302568448 |
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| author | Bruno Stuhlmüller Udo Schneider José-B. González-González José-B. González-González Eugen Feist |
| author_facet | Bruno Stuhlmüller Udo Schneider José-B. González-González José-B. González-González Eugen Feist |
| author_sort | Bruno Stuhlmüller |
| collection | DOAJ |
| description | Idiopathic inflammatory myopathies represent still a diagnostic and therapeutic challenge in different disciplines including neurology, rheumatology, and dermatology. In recent years, the spectrum of idiopathic inflammatory myopathies has been significantly extended and the different manifestations were described in more detail leading to new classification criteria. A major breakthrough has also occurred with respect to new biomarkers especially with the characterization of new autoantibody-antigen systems, which can be separated in myositis specific antibodies and myositis associated antibodies. These markers are detectable in approximately 80% of patients and facilitate not only the diagnostic procedures, but provide also important information on stratification of patients with respect to organ involvement, risk of cancer and overall prognosis of disease. Therefore, it is not only of importance to know the significance of these markers and to be familiar with the optimal diagnostic tests, but also with potential limitations in detection. This article focuses mainly on antibodies which are specific for myositis providing an overview on the targeted antigens, the available detection procedures and clinical association. As major tasks for the near future, the need of an international standardization is discussed for detection methods of autoantibodies in idiopathic inflammatory myopathies. Furthermore, additional investigations are required to improve stratification of patients with idiopathic inflammatory myopathies according to their antibody profile with respect to response to different treatment options. |
| first_indexed | 2024-12-20T00:20:20Z |
| format | Article |
| id | doaj.art-e6788e7edd56487c9c0ff53a92e05ca8 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-20T00:20:20Z |
| publishDate | 2019-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-e6788e7edd56487c9c0ff53a92e05ca82022-12-21T20:00:13ZengFrontiers Media S.A.Frontiers in Neurology1664-22952019-05-011010.3389/fneur.2019.00438440739Disease Specific Autoantibodies in Idiopathic Inflammatory MyopathiesBruno Stuhlmüller0Udo Schneider1José-B. González-González2José-B. González-González3Eugen Feist4Department of Rheumatology and Clinical Immunology, Charité-Universitätsmedizin, Berlin, GermanyDepartment of Rheumatology and Clinical Immunology, Charité-Universitätsmedizin, Berlin, GermanyDepartment of Rheumatology and Clinical Immunology, Charité-Universitätsmedizin, Berlin, GermanyLabor Berlin-Charité Vivantes GmbH, Berlin, GermanyDepartment of Rheumatology and Clinical Immunology, Charité-Universitätsmedizin, Berlin, GermanyIdiopathic inflammatory myopathies represent still a diagnostic and therapeutic challenge in different disciplines including neurology, rheumatology, and dermatology. In recent years, the spectrum of idiopathic inflammatory myopathies has been significantly extended and the different manifestations were described in more detail leading to new classification criteria. A major breakthrough has also occurred with respect to new biomarkers especially with the characterization of new autoantibody-antigen systems, which can be separated in myositis specific antibodies and myositis associated antibodies. These markers are detectable in approximately 80% of patients and facilitate not only the diagnostic procedures, but provide also important information on stratification of patients with respect to organ involvement, risk of cancer and overall prognosis of disease. Therefore, it is not only of importance to know the significance of these markers and to be familiar with the optimal diagnostic tests, but also with potential limitations in detection. This article focuses mainly on antibodies which are specific for myositis providing an overview on the targeted antigens, the available detection procedures and clinical association. As major tasks for the near future, the need of an international standardization is discussed for detection methods of autoantibodies in idiopathic inflammatory myopathies. Furthermore, additional investigations are required to improve stratification of patients with idiopathic inflammatory myopathies according to their antibody profile with respect to response to different treatment options.https://www.frontiersin.org/article/10.3389/fneur.2019.00438/fullmyositisinflammationautoantibodiesantigensbiomarker |
| spellingShingle | Bruno Stuhlmüller Udo Schneider José-B. González-González José-B. González-González Eugen Feist Disease Specific Autoantibodies in Idiopathic Inflammatory Myopathies Frontiers in Neurology myositis inflammation autoantibodies antigens biomarker |
| title | Disease Specific Autoantibodies in Idiopathic Inflammatory Myopathies |
| title_full | Disease Specific Autoantibodies in Idiopathic Inflammatory Myopathies |
| title_fullStr | Disease Specific Autoantibodies in Idiopathic Inflammatory Myopathies |
| title_full_unstemmed | Disease Specific Autoantibodies in Idiopathic Inflammatory Myopathies |
| title_short | Disease Specific Autoantibodies in Idiopathic Inflammatory Myopathies |
| title_sort | disease specific autoantibodies in idiopathic inflammatory myopathies |
| topic | myositis inflammation autoantibodies antigens biomarker |
| url | https://www.frontiersin.org/article/10.3389/fneur.2019.00438/full |
| work_keys_str_mv | AT brunostuhlmuller diseasespecificautoantibodiesinidiopathicinflammatorymyopathies AT udoschneider diseasespecificautoantibodiesinidiopathicinflammatorymyopathies AT josebgonzalezgonzalez diseasespecificautoantibodiesinidiopathicinflammatorymyopathies AT josebgonzalezgonzalez diseasespecificautoantibodiesinidiopathicinflammatorymyopathies AT eugenfeist diseasespecificautoantibodiesinidiopathicinflammatorymyopathies |