Camouflaging bacteria by wrapping with cell membranes
The use of engineered bacteria for biomedical applications is limited by side effects such as inflammatory response. Here the authors engineer cell membrane coated bacteria as in vivo tumor imaging agents, and show that these generate a lower inflammatory response and reduced macrophage clearance.
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-08-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-11390-8 |
| _version_ | 1818342054384631808 |
|---|---|
| author | Zhenping Cao Shanshan Cheng Xinyue Wang Yan Pang Jinyao Liu |
| author_facet | Zhenping Cao Shanshan Cheng Xinyue Wang Yan Pang Jinyao Liu |
| author_sort | Zhenping Cao |
| collection | DOAJ |
| description | The use of engineered bacteria for biomedical applications is limited by side effects such as inflammatory response. Here the authors engineer cell membrane coated bacteria as in vivo tumor imaging agents, and show that these generate a lower inflammatory response and reduced macrophage clearance. |
| first_indexed | 2024-12-13T16:08:35Z |
| format | Article |
| id | doaj.art-e6795b3878514a098385a3a4a86f7461 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:08:35Z |
| publishDate | 2019-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-e6795b3878514a098385a3a4a86f74612022-12-21T23:38:59ZengNature PortfolioNature Communications2041-17232019-08-0110111010.1038/s41467-019-11390-8Camouflaging bacteria by wrapping with cell membranesZhenping Cao0Shanshan Cheng1Xinyue Wang2Yan Pang3Jinyao Liu4Institute of Molecular Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Institute of Cancer, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityInstitute of Molecular Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Institute of Cancer, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityInstitute of Molecular Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Institute of Cancer, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Ophthalmology, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong UniversityInstitute of Molecular Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Institute of Cancer, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityThe use of engineered bacteria for biomedical applications is limited by side effects such as inflammatory response. Here the authors engineer cell membrane coated bacteria as in vivo tumor imaging agents, and show that these generate a lower inflammatory response and reduced macrophage clearance.https://doi.org/10.1038/s41467-019-11390-8 |
| spellingShingle | Zhenping Cao Shanshan Cheng Xinyue Wang Yan Pang Jinyao Liu Camouflaging bacteria by wrapping with cell membranes Nature Communications |
| title | Camouflaging bacteria by wrapping with cell membranes |
| title_full | Camouflaging bacteria by wrapping with cell membranes |
| title_fullStr | Camouflaging bacteria by wrapping with cell membranes |
| title_full_unstemmed | Camouflaging bacteria by wrapping with cell membranes |
| title_short | Camouflaging bacteria by wrapping with cell membranes |
| title_sort | camouflaging bacteria by wrapping with cell membranes |
| url | https://doi.org/10.1038/s41467-019-11390-8 |
| work_keys_str_mv | AT zhenpingcao camouflagingbacteriabywrappingwithcellmembranes AT shanshancheng camouflagingbacteriabywrappingwithcellmembranes AT xinyuewang camouflagingbacteriabywrappingwithcellmembranes AT yanpang camouflagingbacteriabywrappingwithcellmembranes AT jinyaoliu camouflagingbacteriabywrappingwithcellmembranes |