Phylogenetic Analysis of Pyruvate-Ferredoxin Oxidoreductase, a Redox Enzyme Involved in the Pharmacological Activation of Nitro-Based Prodrugs in Bacteria and Protozoa

Phylogenetic Analysis of Pyruvate-Ferredoxin Oxidoreductase, a Redox Enzyme Involved in the Pharmacological Activation of Nitro-Based Prodrugs in Bacteria and Protozoa

The present frontrunners in the chemotherapy of infections caused by protozoa are nitro-based prodrugs that are selectively activated by PFOR-mediated redox reactions. This study seeks to analyze the distribution of PFOR in selected protozoa and bacteria by applying comparative genomics to test the...

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Bibliographic Details
Main Authors:	Seth Duwor, Daniela Brites, Pascal Mäser
Format:	Article
Language:	English
Published:	MDPI AG 2024-03-01
Series:	Biology
Subjects:	pyruvate-ferredoxin oxidoreductase metronidazole reductive bioactivation antimicrobial spectrum comparative genomics horizontal gene transfer
Online Access:	https://www.mdpi.com/2079-7737/13/3/178

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