Consequences of CRISPR-Cas9-Mediated CFTR Knockout in Human Macrophages

Consequences of CRISPR-Cas9-Mediated CFTR Knockout in Human Macrophages

Macrophage dysfunction is fundamentally related to altered immunity in cystic fibrosis (CF). How genetic deficits in the cystic fibrosis transmembrane conductance regulator (CFTR) lead to these defects remains unknown. Rapid advances in genomic editing such as the clustered regularly interspaced sho...

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Bibliographic Details
Main Authors: Shuzhong Zhang, Chandra L. Shrestha, Benjamin L. Wisniewski, Hanh Pham, Xucheng Hou, Wenqing Li, Yizhou Dong, Benjamin T. Kopp
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
cystic fibrosis
macrophage
bacteria
CRISPR
CFTR
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01871/full

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