Antibiotic Alternatives: The Substitution of Antibiotics in Animal Husbandry?
It is a common practice for decades to use of sub-therapeutic dose of antibiotics in food-animal feeds to prevent animals from diseases and to improve production performance in modern animal husbandry. In the meantime, concerns over the increasing emergence of antibiotic-resistant bacteria due to th...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-05-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00217/full |
| _version_ | 1819263658356637696 |
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| author | Guyue eCheng Haihong eHao Shuyu eXie Xu eWang Menghong eDai Lingli eHuang Zong-Hui eYuan |
| author_facet | Guyue eCheng Haihong eHao Shuyu eXie Xu eWang Menghong eDai Lingli eHuang Zong-Hui eYuan |
| author_sort | Guyue eCheng |
| collection | DOAJ |
| description | It is a common practice for decades to use of sub-therapeutic dose of antibiotics in food-animal feeds to prevent animals from diseases and to improve production performance in modern animal husbandry. In the meantime, concerns over the increasing emergence of antibiotic-resistant bacteria due to the unreasonable use of antibiotics and an appearance of less novelty antibiotics have prompted efforts to develop so-called alternatives to antibiotics. Whether or not the alternatives could relly replace antibiotics remains a controversial issue. This review summarizes recent development and perspectives of alternatives to antibiotics. The mechanism of actions, applications, and prospectives of the alternatives such as immunity modulating agents, bacteriophages and their lysins, antimicrobial peptides, pro-, pre- and synbiotics, plant extracts, inhibitors targeting pathogenicity (bacterial quorum sensing, biofilm and virulence), and feeding enzymes are thoroughly discussed. Lastly, the feasibility of alternatives to antibiotics is deeply analyzed. It is hard to conclude that the alternatives might substitute antibiotics in veterinary medicine in the foreseeable future. At the present time, prudent use of antibiotics and the establishment of scientific monitoring systems are the best and fastest way to limit the adverse effects of the abuse of antibiotics and to ensure the safety of animal-derived food and environment. |
| first_indexed | 2024-12-23T20:17:05Z |
| format | Article |
| id | doaj.art-e67ba83f8933491ab1b28a366bb0b1f8 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-23T20:17:05Z |
| publishDate | 2014-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-e67ba83f8933491ab1b28a366bb0b1f82022-12-21T17:32:40ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2014-05-01510.3389/fmicb.2014.0021787626Antibiotic Alternatives: The Substitution of Antibiotics in Animal Husbandry?Guyue eCheng0Haihong eHao1Shuyu eXie2Xu eWang3Menghong eDai4Lingli eHuang5Zong-Hui eYuan6Huazhong Agricultural UniversityHuazhong Agricultural UniversityHuazhong Agricultural UniversityHuazhong Agricultural UniversityHuazhong Agricultural UniversityHuazhong Agricultural UniversityHuazhong Agricultural UniversityIt is a common practice for decades to use of sub-therapeutic dose of antibiotics in food-animal feeds to prevent animals from diseases and to improve production performance in modern animal husbandry. In the meantime, concerns over the increasing emergence of antibiotic-resistant bacteria due to the unreasonable use of antibiotics and an appearance of less novelty antibiotics have prompted efforts to develop so-called alternatives to antibiotics. Whether or not the alternatives could relly replace antibiotics remains a controversial issue. This review summarizes recent development and perspectives of alternatives to antibiotics. The mechanism of actions, applications, and prospectives of the alternatives such as immunity modulating agents, bacteriophages and their lysins, antimicrobial peptides, pro-, pre- and synbiotics, plant extracts, inhibitors targeting pathogenicity (bacterial quorum sensing, biofilm and virulence), and feeding enzymes are thoroughly discussed. Lastly, the feasibility of alternatives to antibiotics is deeply analyzed. It is hard to conclude that the alternatives might substitute antibiotics in veterinary medicine in the foreseeable future. At the present time, prudent use of antibiotics and the establishment of scientific monitoring systems are the best and fastest way to limit the adverse effects of the abuse of antibiotics and to ensure the safety of animal-derived food and environment.http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00217/fullPublic Healthantibioticsantimicrobial resistancealternatives to antibioticsveterinary medicien |
| spellingShingle | Guyue eCheng Haihong eHao Shuyu eXie Xu eWang Menghong eDai Lingli eHuang Zong-Hui eYuan Antibiotic Alternatives: The Substitution of Antibiotics in Animal Husbandry? Frontiers in Microbiology Public Health antibiotics antimicrobial resistance alternatives to antibiotics veterinary medicien |
| title | Antibiotic Alternatives: The Substitution of Antibiotics in Animal Husbandry? |
| title_full | Antibiotic Alternatives: The Substitution of Antibiotics in Animal Husbandry? |
| title_fullStr | Antibiotic Alternatives: The Substitution of Antibiotics in Animal Husbandry? |
| title_full_unstemmed | Antibiotic Alternatives: The Substitution of Antibiotics in Animal Husbandry? |
| title_short | Antibiotic Alternatives: The Substitution of Antibiotics in Animal Husbandry? |
| title_sort | antibiotic alternatives the substitution of antibiotics in animal husbandry |
| topic | Public Health antibiotics antimicrobial resistance alternatives to antibiotics veterinary medicien |
| url | http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00217/full |
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