Cyclovirobuxine D Induced-Mitophagy through the p65/BNIP3/LC3 Axis Potentiates Its Apoptosis-Inducing Effects in Lung Cancer Cells

Cyclovirobuxine D Induced-Mitophagy through the p65/BNIP3/LC3 Axis Potentiates Its Apoptosis-Inducing Effects in Lung Cancer Cells

Mitophagy plays a pro-survival or pro-death role that is cellular-context- and stress-condition-dependent. In this study, we revealed that cyclovirobuxine D (CVB-D), a natural compound derived from <i>Buxus microphylla</i>, was able to provoke mitophagy in lung cancer cells. CVB-D-induce...

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Bibliographic Details
Main Authors: Cheng Zeng, Tingting Zou, Junyan Qu, Xu Chen, Suping Zhang, Zhenghong Lin
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
cyclovirobuxine D
BNIP3
mitophagy
apoptosis
lung cancer
Online Access:https://www.mdpi.com/1422-0067/22/11/5820

Internet

https://www.mdpi.com/1422-0067/22/11/5820

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