Radiological correlates of vocal fold bowing as markers of Parkinson’s disease progression: A cross-sectional study utilizing dynamic laryngeal CT
<h4>Objective</h4> To determine whether arytenoid cartilage position and dynamics change with advancing duration and severity (as graded by MDS-UPDRS part III scores) in Parkinson’s disease, in a cross-sectional study design, we performed laryngeal four-dimensional computed tomography (4...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519464/?tool=EBI |
| _version_ | 1819199462934839296 |
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| author | Andrew Ma Kenneth K. Lau Dominic Thyagarajan |
| author_facet | Andrew Ma Kenneth K. Lau Dominic Thyagarajan |
| author_sort | Andrew Ma |
| collection | DOAJ |
| description | <h4>Objective</h4> To determine whether arytenoid cartilage position and dynamics change with advancing duration and severity (as graded by MDS-UPDRS part III scores) in Parkinson’s disease, in a cross-sectional study design, we performed laryngeal four-dimensional computed tomography (4D-CT) in people with Parkinson’s disease and controls. <h4>Methods</h4> 31 people with Parkinson’s disease covering a range of disease duration and severity and 19 controls underwent laryngeal 4D-CT whilst repeatedly vocalizing. We measured on each CT volume the glottic area (GA), inter-arytenoid distance (IAD), IAD-Area index (IAI) and arytenoid cartilage velocity ( <h4>Results</h4> People with Parkinson’s disease had reductions in the mean/effective minimum IAD when compared to controls, while mean/effective minimum GA and mean/effective maximum IAI were increased. Arytenoid cartilage velocities showed no difference. On Spearman correlation analyses, advancing disease duration and severity of PD showed moderately strong and significant correlations with increasing mean/effective minimum GA, increasing mean/effective maximum IAI and decreasing effective minimum IAD. Linear mixed models which considered the effects of intra and inter-individual variation showed that both disease duration (b = -0.011, SEb = 0.053, 95% CI [-0.022, 0], t(27) = -2.10, p = 0.045) and severity (b = -0.069, SEb = 0.032, 95% CI [-0.14,-0.0039], t(27) = -2.17, p = 0.039) were significant predictors for IAD, and also for transformed values of the GA and IAI. <h4>Conclusions</h4> There are progressive alterations in phonatory posturing as Parkinson’s disease advances. The increases in GA despite reductions in IAD are concordant with prior observations of vocal fold bowing. Our study provides a basis for using laryngeal 4D-CT to assess disease progression in Parkinson’s disease. |
| first_indexed | 2024-12-23T03:16:44Z |
| format | Article |
| id | doaj.art-e67e759710d74a8a9587f1209b9bcd1b |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T03:16:44Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-e67e759710d74a8a9587f1209b9bcd1b2022-12-21T18:02:04ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-011610Radiological correlates of vocal fold bowing as markers of Parkinson’s disease progression: A cross-sectional study utilizing dynamic laryngeal CTAndrew MaKenneth K. LauDominic Thyagarajan<h4>Objective</h4> To determine whether arytenoid cartilage position and dynamics change with advancing duration and severity (as graded by MDS-UPDRS part III scores) in Parkinson’s disease, in a cross-sectional study design, we performed laryngeal four-dimensional computed tomography (4D-CT) in people with Parkinson’s disease and controls. <h4>Methods</h4> 31 people with Parkinson’s disease covering a range of disease duration and severity and 19 controls underwent laryngeal 4D-CT whilst repeatedly vocalizing. We measured on each CT volume the glottic area (GA), inter-arytenoid distance (IAD), IAD-Area index (IAI) and arytenoid cartilage velocity ( <h4>Results</h4> People with Parkinson’s disease had reductions in the mean/effective minimum IAD when compared to controls, while mean/effective minimum GA and mean/effective maximum IAI were increased. Arytenoid cartilage velocities showed no difference. On Spearman correlation analyses, advancing disease duration and severity of PD showed moderately strong and significant correlations with increasing mean/effective minimum GA, increasing mean/effective maximum IAI and decreasing effective minimum IAD. Linear mixed models which considered the effects of intra and inter-individual variation showed that both disease duration (b = -0.011, SEb = 0.053, 95% CI [-0.022, 0], t(27) = -2.10, p = 0.045) and severity (b = -0.069, SEb = 0.032, 95% CI [-0.14,-0.0039], t(27) = -2.17, p = 0.039) were significant predictors for IAD, and also for transformed values of the GA and IAI. <h4>Conclusions</h4> There are progressive alterations in phonatory posturing as Parkinson’s disease advances. The increases in GA despite reductions in IAD are concordant with prior observations of vocal fold bowing. Our study provides a basis for using laryngeal 4D-CT to assess disease progression in Parkinson’s disease.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519464/?tool=EBI |
| spellingShingle | Andrew Ma Kenneth K. Lau Dominic Thyagarajan Radiological correlates of vocal fold bowing as markers of Parkinson’s disease progression: A cross-sectional study utilizing dynamic laryngeal CT PLoS ONE |
| title | Radiological correlates of vocal fold bowing as markers of Parkinson’s disease progression: A cross-sectional study utilizing dynamic laryngeal CT |
| title_full | Radiological correlates of vocal fold bowing as markers of Parkinson’s disease progression: A cross-sectional study utilizing dynamic laryngeal CT |
| title_fullStr | Radiological correlates of vocal fold bowing as markers of Parkinson’s disease progression: A cross-sectional study utilizing dynamic laryngeal CT |
| title_full_unstemmed | Radiological correlates of vocal fold bowing as markers of Parkinson’s disease progression: A cross-sectional study utilizing dynamic laryngeal CT |
| title_short | Radiological correlates of vocal fold bowing as markers of Parkinson’s disease progression: A cross-sectional study utilizing dynamic laryngeal CT |
| title_sort | radiological correlates of vocal fold bowing as markers of parkinson s disease progression a cross sectional study utilizing dynamic laryngeal ct |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519464/?tool=EBI |
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