Single-cell spatial transcriptomic analysis reveals common and divergent features of developing postnatal granule cerebellar cells and medulloblastoma

Single-cell spatial transcriptomic analysis reveals common and divergent features of developing postnatal granule cerebellar cells and medulloblastoma

Abstract Background Cerebellar neurogenesis involves the generation of large numbers of cerebellar granule neurons (GNs) throughout development of the cerebellum, a process that involves tight regulation of proliferation and differentiation of granule neuron progenitors (GNPs). A number of transcrip...

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Main Authors: Wenqin Luo, Guan Ning Lin, Weichen Song, Yu Zhang, Huadong Lai, Man Zhang, Juju Miao, Xiaomu Cheng, Yongjie Wang, Wang Li, Wenxiang Wei, Wei-Qiang Gao, Ru Yang, Jia Wang
Format: Article
Language:English
Published: BMC 2021-07-01
Series:BMC Biology
Subjects:
Cerebellum
Development of granule cells
Granule neuron progenitors
Differentiated granule neurons
SHH medulloblastoma
Single-cell RNA sequencing
Online Access:https://doi.org/10.1186/s12915-021-01071-8

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