Efficacy of intravenous dexamethasone for post-operative pain relief in elective cesarean section
Background: Various additives have been evaluated for the purpose of enhancing quality of analgesia and prolonging duration of spinal anesthesia. Aims and Objectives: This randomized study was conducted to evaluate the efficacy of intravenous dexamethasone in spinal anesthesia. Materials and M...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2023-03-01
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| Series: | Asian Journal of Medical Sciences |
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| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/50324 |
| _version_ | 1811162046167777280 |
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| author | Swetha Purohit Chandrashekarappa Kavi Shobha MM |
| author_facet | Swetha Purohit Chandrashekarappa Kavi Shobha MM |
| author_sort | Swetha Purohit |
| collection | DOAJ |
| description | Background: Various additives have been evaluated for the purpose of enhancing quality of analgesia and prolonging duration of spinal anesthesia.
Aims and Objectives: This randomized study was conducted to evaluate the efficacy of intravenous dexamethasone in spinal anesthesia.
Materials and Methods: A total of 100 patients scheduled for lower segment cesarean section under spinal anesthesia were randomly allocated into two groups, Group-1 and Group-2, including 50 patients each. All the patients received injection bupivacaine 0.5% heavy 10 mg for spinal anesthesia. Group-1 received injection dexamethasone 8 mg intravenously, and Group-2 received injection normal saline 2 cc immediately after spinal anesthesia. Duration of sensory and motor block, post-operative analgesia, visual analog pain scale (VAS) score, time of rescue analgesia, total analgesic requirement in the first 24 h, intra- and post-operative hemodynamics, and side effects if any were recorded.
Results: The mean duration of sensory block (min) in Group-1 and Group-2 was 162.50 and 106.17, respectively. Time to the requirement of first rescue analgesia was 8.67 h in Group-1 and 4.40 h in Group-2. Significant changes seen in VAS score in post-operative period after 1 h of surgery in Group-1 and Group-2. Group-1 had more duration of sensory block, prolonged requirement of first rescue analgesia. Duration of motor block and intra- and post-operative hemodynamic parameters was comparable in both the groups. No side effects were recorded in both the groups.
Conclusion: We conclude that administration of dexamethasone 8 mg intravenously prolongs the duration of post-operative analgesia and sensory block in patients undergoing lower segment cesarean section under spinal anesthesia. |
| first_indexed | 2024-04-10T06:23:19Z |
| format | Article |
| id | doaj.art-e680a96589a3495ba8fca54de7882d7b |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-04-10T06:23:19Z |
| publishDate | 2023-03-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-e680a96589a3495ba8fca54de7882d7b2023-03-02T01:03:44ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762023-03-011437176https://doi.org/10.3126/ajms.v14i3.50324Efficacy of intravenous dexamethasone for post-operative pain relief in elective cesarean sectionSwetha Purohit 0https://orcid.org/0000-0002-0866-654XChandrashekarappa Kavi 1https://orcid.org/0000-0002-1015-3233Shobha MM 2https://orcid.org/0000-0002-0970-8430Associate Professor, Department of Anesthesiology, Subbaiah Institute of Medical Sciences, Shivamogga, Karnataka, India Professor, Department of Anesthesiology, Subbaiah Institute of Medical Sciences, Shivamogga, Karnataka, India Assistant Professor, Department of Anesthesiology, Subbaiah Institute of Medical Sciences, Shivamogga, Karnataka, India Background: Various additives have been evaluated for the purpose of enhancing quality of analgesia and prolonging duration of spinal anesthesia. Aims and Objectives: This randomized study was conducted to evaluate the efficacy of intravenous dexamethasone in spinal anesthesia. Materials and Methods: A total of 100 patients scheduled for lower segment cesarean section under spinal anesthesia were randomly allocated into two groups, Group-1 and Group-2, including 50 patients each. All the patients received injection bupivacaine 0.5% heavy 10 mg for spinal anesthesia. Group-1 received injection dexamethasone 8 mg intravenously, and Group-2 received injection normal saline 2 cc immediately after spinal anesthesia. Duration of sensory and motor block, post-operative analgesia, visual analog pain scale (VAS) score, time of rescue analgesia, total analgesic requirement in the first 24 h, intra- and post-operative hemodynamics, and side effects if any were recorded. Results: The mean duration of sensory block (min) in Group-1 and Group-2 was 162.50 and 106.17, respectively. Time to the requirement of first rescue analgesia was 8.67 h in Group-1 and 4.40 h in Group-2. Significant changes seen in VAS score in post-operative period after 1 h of surgery in Group-1 and Group-2. Group-1 had more duration of sensory block, prolonged requirement of first rescue analgesia. Duration of motor block and intra- and post-operative hemodynamic parameters was comparable in both the groups. No side effects were recorded in both the groups. Conclusion: We conclude that administration of dexamethasone 8 mg intravenously prolongs the duration of post-operative analgesia and sensory block in patients undergoing lower segment cesarean section under spinal anesthesia.https://www.nepjol.info/index.php/AJMS/article/view/50324dexamethasone; post-operative analgesia; spinal anesthesia |
| spellingShingle | Swetha Purohit Chandrashekarappa Kavi Shobha MM Efficacy of intravenous dexamethasone for post-operative pain relief in elective cesarean section Asian Journal of Medical Sciences dexamethasone; post-operative analgesia; spinal anesthesia |
| title | Efficacy of intravenous dexamethasone for post-operative pain relief in elective cesarean section |
| title_full | Efficacy of intravenous dexamethasone for post-operative pain relief in elective cesarean section |
| title_fullStr | Efficacy of intravenous dexamethasone for post-operative pain relief in elective cesarean section |
| title_full_unstemmed | Efficacy of intravenous dexamethasone for post-operative pain relief in elective cesarean section |
| title_short | Efficacy of intravenous dexamethasone for post-operative pain relief in elective cesarean section |
| title_sort | efficacy of intravenous dexamethasone for post operative pain relief in elective cesarean section |
| topic | dexamethasone; post-operative analgesia; spinal anesthesia |
| url | https://www.nepjol.info/index.php/AJMS/article/view/50324 |
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