Amblyomma sculptum Salivary PGE2 Modulates the Dendritic Cell-Rickettsia rickettsii Interactions in vitro and in vivo

Amblyomma sculptum Salivary PGE2 Modulates the Dendritic Cell-Rickettsia rickettsii Interactions in vitro and in vivo

Amblyomma sculptum is an important vector of Rickettsia rickettsii, causative agent of Rocky Mountain spotted fever and the most lethal tick-borne pathogen affecting humans. To feed on the vertebrate host's blood, A. sculptum secretes a salivary mixture, which may interact with skin resident de...

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Bibliographic Details
Main Authors: Eliane Esteves, Bruna Bizzarro, Francisco Borges Costa, Alejandro Ramírez-Hernández, Ana Paula Ferranti Peti, Allan Henrique Depieri Cataneo, Pryscilla Fanini Wowk, Rodolfo Pessato Timóteo, Marcelo Bahia Labruna, Pedro Ismael Silva Junior, Célio Lopes Silva, Lúcia Helena Faccioli, Andréa Cristina Fogaça, Carlos Arterio Sorgi, Anderson Sá-Nunes
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
Amblyomma sculptum
tick saliva
PGE2
dendritic cells
Rickettsia rickettsii
immunomodulation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00118/full

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