Challenges and lessons learned from the rapid operationalization of a prospective cohort to study the natural history and neurodevelopmental outcomes of postnatal Zika virus infection among infants and children in rural Guatemala.
During the course of the 2015-2017 outbreak of Zika virus (ZIKV) in the Americas, the emerging virus was recognized as a congenital infection that could damage the developing brain. As the Latin American ZIKV outbreak advanced, the scientific and public health community questioned if this newly reco...
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-11-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://doi.org/10.1371/journal.pntd.0010480 |
| _version_ | 1828091271843938304 |
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| author | Alejandra Paniagua-Avila Daniel Olson Amy Connery D Mirella Calvimontes Guillermo A Bolanos Molly M Lamb Desiree Bauer Aida Ralda Neudy Rojop Eduardo Barrios Andrea Chacon Melissa Gomez Paola Arroyave Sara Hernandez Maria Alejandra Martinez Saskia Bunge-Montes Alison Colbert Kareen Arias Garret Brazeale Andrea Holliday Kay M Tomashek Hana M El Sahly Wendy Keitel Flor M Munoz Edwin J Asturias |
| author_facet | Alejandra Paniagua-Avila Daniel Olson Amy Connery D Mirella Calvimontes Guillermo A Bolanos Molly M Lamb Desiree Bauer Aida Ralda Neudy Rojop Eduardo Barrios Andrea Chacon Melissa Gomez Paola Arroyave Sara Hernandez Maria Alejandra Martinez Saskia Bunge-Montes Alison Colbert Kareen Arias Garret Brazeale Andrea Holliday Kay M Tomashek Hana M El Sahly Wendy Keitel Flor M Munoz Edwin J Asturias |
| author_sort | Alejandra Paniagua-Avila |
| collection | DOAJ |
| description | During the course of the 2015-2017 outbreak of Zika virus (ZIKV) in the Americas, the emerging virus was recognized as a congenital infection that could damage the developing brain. As the Latin American ZIKV outbreak advanced, the scientific and public health community questioned if this newly recognized neurotropic flavivirus could affect the developing brain of infants and young children infected after birth. We report here the study design, methods and the challenges and lessons learned from the rapid operationalization of a prospective natural history cohort study aimed at evaluating the potential neurological and neurodevelopmental effects of postnatal ZIKV infection in infants and young children, which had become epidemic in Central America. This study enrolled a cohort of 500 mothers and their infants, along with nearly 400 children 1.5-3.5 years of age who were born during the initial phase of the ZIKV epidemic in a rural area of Guatemala. Our solutions and lessons learned while tackling real-life challenges may serve as a guide to other researchers carrying out studies of emerging infectious diseases of public health priority in resource-constrained settings. |
| first_indexed | 2024-04-11T06:10:16Z |
| format | Article |
| id | doaj.art-e684d229eef4414f8513ebc93aa75477 |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-04-11T06:10:16Z |
| publishDate | 2022-11-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-e684d229eef4414f8513ebc93aa754772022-12-22T04:41:18ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352022-11-011611e001048010.1371/journal.pntd.0010480Challenges and lessons learned from the rapid operationalization of a prospective cohort to study the natural history and neurodevelopmental outcomes of postnatal Zika virus infection among infants and children in rural Guatemala.Alejandra Paniagua-AvilaDaniel OlsonAmy ConneryD Mirella CalvimontesGuillermo A BolanosMolly M LambDesiree BauerAida RaldaNeudy RojopEduardo BarriosAndrea ChaconMelissa GomezPaola ArroyaveSara HernandezMaria Alejandra MartinezSaskia Bunge-MontesAlison ColbertKareen AriasGarret BrazealeAndrea HollidayKay M TomashekHana M El SahlyWendy KeitelFlor M MunozEdwin J AsturiasDuring the course of the 2015-2017 outbreak of Zika virus (ZIKV) in the Americas, the emerging virus was recognized as a congenital infection that could damage the developing brain. As the Latin American ZIKV outbreak advanced, the scientific and public health community questioned if this newly recognized neurotropic flavivirus could affect the developing brain of infants and young children infected after birth. We report here the study design, methods and the challenges and lessons learned from the rapid operationalization of a prospective natural history cohort study aimed at evaluating the potential neurological and neurodevelopmental effects of postnatal ZIKV infection in infants and young children, which had become epidemic in Central America. This study enrolled a cohort of 500 mothers and their infants, along with nearly 400 children 1.5-3.5 years of age who were born during the initial phase of the ZIKV epidemic in a rural area of Guatemala. Our solutions and lessons learned while tackling real-life challenges may serve as a guide to other researchers carrying out studies of emerging infectious diseases of public health priority in resource-constrained settings.https://doi.org/10.1371/journal.pntd.0010480 |
| spellingShingle | Alejandra Paniagua-Avila Daniel Olson Amy Connery D Mirella Calvimontes Guillermo A Bolanos Molly M Lamb Desiree Bauer Aida Ralda Neudy Rojop Eduardo Barrios Andrea Chacon Melissa Gomez Paola Arroyave Sara Hernandez Maria Alejandra Martinez Saskia Bunge-Montes Alison Colbert Kareen Arias Garret Brazeale Andrea Holliday Kay M Tomashek Hana M El Sahly Wendy Keitel Flor M Munoz Edwin J Asturias Challenges and lessons learned from the rapid operationalization of a prospective cohort to study the natural history and neurodevelopmental outcomes of postnatal Zika virus infection among infants and children in rural Guatemala. PLoS Neglected Tropical Diseases |
| title | Challenges and lessons learned from the rapid operationalization of a prospective cohort to study the natural history and neurodevelopmental outcomes of postnatal Zika virus infection among infants and children in rural Guatemala. |
| title_full | Challenges and lessons learned from the rapid operationalization of a prospective cohort to study the natural history and neurodevelopmental outcomes of postnatal Zika virus infection among infants and children in rural Guatemala. |
| title_fullStr | Challenges and lessons learned from the rapid operationalization of a prospective cohort to study the natural history and neurodevelopmental outcomes of postnatal Zika virus infection among infants and children in rural Guatemala. |
| title_full_unstemmed | Challenges and lessons learned from the rapid operationalization of a prospective cohort to study the natural history and neurodevelopmental outcomes of postnatal Zika virus infection among infants and children in rural Guatemala. |
| title_short | Challenges and lessons learned from the rapid operationalization of a prospective cohort to study the natural history and neurodevelopmental outcomes of postnatal Zika virus infection among infants and children in rural Guatemala. |
| title_sort | challenges and lessons learned from the rapid operationalization of a prospective cohort to study the natural history and neurodevelopmental outcomes of postnatal zika virus infection among infants and children in rural guatemala |
| url | https://doi.org/10.1371/journal.pntd.0010480 |
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