Facile synthesis of Fe2O3, Fe2O3@CuO and WO3 nanoparticles: characterization, structure determination and evaluation of their biological activity
Abstract Due to their high specific surface area and its characteristic’s functionalized nanomaterials have great potential in medical applications specialty, as an anticancer. Herein, functional nanoparticles (NPs) based on iron oxide Fe2O3, iron oxide modified with copper oxide Fe2O3@CuO, and tung...
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Nature Portfolio
2024-03-01
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| Online Access: | https://doi.org/10.1038/s41598-024-55319-8 |
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| author | Asmaa T. Mohamed Reda Abdel Hameed Shahira H. EL-Moslamy Mohamed Fareid Mohamad Othman Samah A. Loutfy Elbadawy A. Kamoun Mohamed Elnouby |
| author_facet | Asmaa T. Mohamed Reda Abdel Hameed Shahira H. EL-Moslamy Mohamed Fareid Mohamad Othman Samah A. Loutfy Elbadawy A. Kamoun Mohamed Elnouby |
| author_sort | Asmaa T. Mohamed |
| collection | DOAJ |
| description | Abstract Due to their high specific surface area and its characteristic’s functionalized nanomaterials have great potential in medical applications specialty, as an anticancer. Herein, functional nanoparticles (NPs) based on iron oxide Fe2O3, iron oxide modified with copper oxide Fe2O3@CuO, and tungsten oxide WO3 were facile synthesized for biomedical applications. The obtained nanomaterials have nanocrystal sizes of 35.5 nm for Fe2O3, 7 nm for Fe2O3@CuO, and 25.5 nm for WO3. In addition to octahedral and square nanoplates for Fe2O3, and WO3; respectively. Results revealed that Fe2O3, Fe2O3@CuO, and WO3 NPs showed remarked anticancer effects versus a safe effect on normal cells through cytotoxicity test using MTT-assay. Notably, synthesized NPs e.g. our result demonstrated that Fe2O3@CuO exhibited the lowest IC50 value on the MCF-7 cancer cell line at about 8.876 µg/ml, compared to Fe2O3 was 12.87 µg/ml and WO3 was 9.211 µg/ml which indicate that the modification NPs Fe2O3@CuO gave the highest antiproliferative effect against breast cancer. However, these NPs showed a safe mode toward the Vero normal cell line, where IC50 were monitored as 40.24 µg/ml for Fe2O3, 21.13 µg/ml for Fe2O3@CuO, and 25.41 µg/ml for WO3 NPs. For further evidence. The antiviral activity using virucidal and viral adsorption mechanisms gave practiced effect by viral adsorption mechanism and prevented the virus from replicating inside the cells. Fe2O3@CuO and WO3 NPs showed a complete reduction in the viral load synergistic effect of combinations between the tested two materials copper oxide instead of iron oxide alone. Interestingly, the antimicrobial efficiency of Fe2O3@CuO NPs, Fe2O3NPs, and WO3NPs was evaluated using E. coli, S. aureus, and C. albicans pathogens. The widest microbial inhibition zone (ca. 38.45 mm) was observed with 250 mg/ml of WO3 NPs against E. coli, whereas using 40 mg/ml of Fe2O3@CuO NPS could form microbial inhibition zone ca. 32.86 mm against S. aureus. Nevertheless, C. albicans was relatively resistant to all examined NPs. The superior biomedical activities of these nanostructures might be due to their unique features and accepted evaluations. |
| first_indexed | 2024-04-24T23:08:41Z |
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| id | doaj.art-e685180d256d43f5922a5e39d600434e |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-24T23:08:41Z |
| publishDate | 2024-03-01 |
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| spelling | doaj.art-e685180d256d43f5922a5e39d600434e2024-03-17T12:23:20ZengNature PortfolioScientific Reports2045-23222024-03-0114111510.1038/s41598-024-55319-8Facile synthesis of Fe2O3, Fe2O3@CuO and WO3 nanoparticles: characterization, structure determination and evaluation of their biological activityAsmaa T. Mohamed0Reda Abdel Hameed1Shahira H. EL-Moslamy2Mohamed Fareid3Mohamad Othman4Samah A. Loutfy5Elbadawy A. Kamoun6Mohamed Elnouby7Nanotechnology Research Center (NTRC), The British University in Egypt, El-Shorouk CityBasic Science Department, Preparatory Year, University of Ha’ilBioprocess Development Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), City of Scientific Research and Technological Applications (SRTA-City)Basic Science Department, Preparatory Year, University of Ha’ilBasic Science Department, Preparatory Year, University of Ha’ilNanotechnology Research Center (NTRC), The British University in Egypt, El-Shorouk CityNanotechnology Research Center (NTRC), The British University in Egypt, El-Shorouk CityNanotechnology and Composite Materials Department, Advanced Technology and New Materials Research (ATNMRI), City of Scientific Research and Technological Applications (SRTA-City)Abstract Due to their high specific surface area and its characteristic’s functionalized nanomaterials have great potential in medical applications specialty, as an anticancer. Herein, functional nanoparticles (NPs) based on iron oxide Fe2O3, iron oxide modified with copper oxide Fe2O3@CuO, and tungsten oxide WO3 were facile synthesized for biomedical applications. The obtained nanomaterials have nanocrystal sizes of 35.5 nm for Fe2O3, 7 nm for Fe2O3@CuO, and 25.5 nm for WO3. In addition to octahedral and square nanoplates for Fe2O3, and WO3; respectively. Results revealed that Fe2O3, Fe2O3@CuO, and WO3 NPs showed remarked anticancer effects versus a safe effect on normal cells through cytotoxicity test using MTT-assay. Notably, synthesized NPs e.g. our result demonstrated that Fe2O3@CuO exhibited the lowest IC50 value on the MCF-7 cancer cell line at about 8.876 µg/ml, compared to Fe2O3 was 12.87 µg/ml and WO3 was 9.211 µg/ml which indicate that the modification NPs Fe2O3@CuO gave the highest antiproliferative effect against breast cancer. However, these NPs showed a safe mode toward the Vero normal cell line, where IC50 were monitored as 40.24 µg/ml for Fe2O3, 21.13 µg/ml for Fe2O3@CuO, and 25.41 µg/ml for WO3 NPs. For further evidence. The antiviral activity using virucidal and viral adsorption mechanisms gave practiced effect by viral adsorption mechanism and prevented the virus from replicating inside the cells. Fe2O3@CuO and WO3 NPs showed a complete reduction in the viral load synergistic effect of combinations between the tested two materials copper oxide instead of iron oxide alone. Interestingly, the antimicrobial efficiency of Fe2O3@CuO NPs, Fe2O3NPs, and WO3NPs was evaluated using E. coli, S. aureus, and C. albicans pathogens. The widest microbial inhibition zone (ca. 38.45 mm) was observed with 250 mg/ml of WO3 NPs against E. coli, whereas using 40 mg/ml of Fe2O3@CuO NPS could form microbial inhibition zone ca. 32.86 mm against S. aureus. Nevertheless, C. albicans was relatively resistant to all examined NPs. The superior biomedical activities of these nanostructures might be due to their unique features and accepted evaluations.https://doi.org/10.1038/s41598-024-55319-8Fe2O3Fe2O3@CuOWO3Biological activity evaluationsFunctionalized nanomaterialsAntiviral |
| spellingShingle | Asmaa T. Mohamed Reda Abdel Hameed Shahira H. EL-Moslamy Mohamed Fareid Mohamad Othman Samah A. Loutfy Elbadawy A. Kamoun Mohamed Elnouby Facile synthesis of Fe2O3, Fe2O3@CuO and WO3 nanoparticles: characterization, structure determination and evaluation of their biological activity Scientific Reports Fe2O3 Fe2O3@CuO WO3 Biological activity evaluations Functionalized nanomaterials Antiviral |
| title | Facile synthesis of Fe2O3, Fe2O3@CuO and WO3 nanoparticles: characterization, structure determination and evaluation of their biological activity |
| title_full | Facile synthesis of Fe2O3, Fe2O3@CuO and WO3 nanoparticles: characterization, structure determination and evaluation of their biological activity |
| title_fullStr | Facile synthesis of Fe2O3, Fe2O3@CuO and WO3 nanoparticles: characterization, structure determination and evaluation of their biological activity |
| title_full_unstemmed | Facile synthesis of Fe2O3, Fe2O3@CuO and WO3 nanoparticles: characterization, structure determination and evaluation of their biological activity |
| title_short | Facile synthesis of Fe2O3, Fe2O3@CuO and WO3 nanoparticles: characterization, structure determination and evaluation of their biological activity |
| title_sort | facile synthesis of fe2o3 fe2o3 cuo and wo3 nanoparticles characterization structure determination and evaluation of their biological activity |
| topic | Fe2O3 Fe2O3@CuO WO3 Biological activity evaluations Functionalized nanomaterials Antiviral |
| url | https://doi.org/10.1038/s41598-024-55319-8 |
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