Immune Modulation of Platelet-Derived Mitochondria on Memory CD4<sup>+</sup> T Cells in Humans
CD4<sup>+</sup> T cells are one of the key immune cells contributing to the immunopathogenesis of type 1 diabetes (T1D). Previous studies have reported that platelet-derived mitochondria suppress the proliferation of peripheral blood mononuclear cells (PBMC). To further characterize the...
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| Format: | Article |
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MDPI AG
2020-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/17/6295 |
| _version_ | 1797555083561402368 |
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| author | Haibo Yu Wei Hu Xiang Song Yong Zhao |
| author_facet | Haibo Yu Wei Hu Xiang Song Yong Zhao |
| author_sort | Haibo Yu |
| collection | DOAJ |
| description | CD4<sup>+</sup> T cells are one of the key immune cells contributing to the immunopathogenesis of type 1 diabetes (T1D). Previous studies have reported that platelet-derived mitochondria suppress the proliferation of peripheral blood mononuclear cells (PBMC). To further characterize the immune modulation of platelet-derived mitochondria, the purified CD4<sup>+</sup> T cells were treated, respectively, with platelet-derived mitochondria. The data demonstrated that MitoTracker Deep Red-labeled platelet-derived mitochondria could directly target CD4<sup>+</sup> T cells through C-X-C motif chemokine receptor 4 (CXCR4) and its ligand stromal cell-derived factor-1 (SDF-1), regulating the anti-CD3/CD28 bead-activated CD4<sup>+</sup> T cells. The result was an up-regulation of Naïve and central memory (T<sub>CM</sub>) CD4<sup>+</sup> T cells, the down-regulation of effector memory (T<sub>EM</sub>) CD4<sup>+</sup> T cells, and modulations of cytokine productions and gene expressions. Thus, platelet-derived mitochondria have a translational potential as novel immune modulators to treat T1D and other autoimmune diseases. |
| first_indexed | 2024-03-10T16:42:24Z |
| format | Article |
| id | doaj.art-e685c01a90ee4e768cae0545e3c87579 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T16:42:24Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e685c01a90ee4e768cae0545e3c875792023-11-20T11:58:04ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-08-012117629510.3390/ijms21176295Immune Modulation of Platelet-Derived Mitochondria on Memory CD4<sup>+</sup> T Cells in HumansHaibo Yu0Wei Hu1Xiang Song2Yong Zhao3Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USACenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USACenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USACenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USACD4<sup>+</sup> T cells are one of the key immune cells contributing to the immunopathogenesis of type 1 diabetes (T1D). Previous studies have reported that platelet-derived mitochondria suppress the proliferation of peripheral blood mononuclear cells (PBMC). To further characterize the immune modulation of platelet-derived mitochondria, the purified CD4<sup>+</sup> T cells were treated, respectively, with platelet-derived mitochondria. The data demonstrated that MitoTracker Deep Red-labeled platelet-derived mitochondria could directly target CD4<sup>+</sup> T cells through C-X-C motif chemokine receptor 4 (CXCR4) and its ligand stromal cell-derived factor-1 (SDF-1), regulating the anti-CD3/CD28 bead-activated CD4<sup>+</sup> T cells. The result was an up-regulation of Naïve and central memory (T<sub>CM</sub>) CD4<sup>+</sup> T cells, the down-regulation of effector memory (T<sub>EM</sub>) CD4<sup>+</sup> T cells, and modulations of cytokine productions and gene expressions. Thus, platelet-derived mitochondria have a translational potential as novel immune modulators to treat T1D and other autoimmune diseases.https://www.mdpi.com/1422-0067/21/17/6295plateletsmitochondriaCD4<sup>+</sup> T cellsimmune modulationcentral memory T cellseffector memory T cells |
| spellingShingle | Haibo Yu Wei Hu Xiang Song Yong Zhao Immune Modulation of Platelet-Derived Mitochondria on Memory CD4<sup>+</sup> T Cells in Humans International Journal of Molecular Sciences platelets mitochondria CD4<sup>+</sup> T cells immune modulation central memory T cells effector memory T cells |
| title | Immune Modulation of Platelet-Derived Mitochondria on Memory CD4<sup>+</sup> T Cells in Humans |
| title_full | Immune Modulation of Platelet-Derived Mitochondria on Memory CD4<sup>+</sup> T Cells in Humans |
| title_fullStr | Immune Modulation of Platelet-Derived Mitochondria on Memory CD4<sup>+</sup> T Cells in Humans |
| title_full_unstemmed | Immune Modulation of Platelet-Derived Mitochondria on Memory CD4<sup>+</sup> T Cells in Humans |
| title_short | Immune Modulation of Platelet-Derived Mitochondria on Memory CD4<sup>+</sup> T Cells in Humans |
| title_sort | immune modulation of platelet derived mitochondria on memory cd4 sup sup t cells in humans |
| topic | platelets mitochondria CD4<sup>+</sup> T cells immune modulation central memory T cells effector memory T cells |
| url | https://www.mdpi.com/1422-0067/21/17/6295 |
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