JAK inhibitors differentially modulate B cell activation, maturation and function: A comparative analysis of five JAK inhibitors in an in-vitro B cell differentiation model and in patients with rheumatoid arthritis

JAK inhibitors differentially modulate B cell activation, maturation and function: A comparative analysis of five JAK inhibitors in an in-vitro B cell differentiation model and in patients with rheumatoid arthritis

BackgroundJanus kinase (JAK) inhibitors have been approved for the treatment of several immune-mediated diseases (IMIDs) including rheumatoid arthritis (RA) and psoriatic arthritis and are in clinical trials for numerous other IMIDs. However, detailed studies investigating the effects of different J...

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Bibliographic Details
Main Authors: Natalie Frede, Raquel Lorenzetti, Janika M Hüppe, Iga Janowska, Arianna Troilo, Marei-Theresa Schleyer, Ana C. Venhoff, Reinhard E. Voll, Jens Thiel, Nils Venhoff, Marta Rizzi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
JAK inhibition
B cells
rheumatoid arthritis
tofacitinib
baricitinib
ruxolitinib
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1087986/full

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