Trifluridine and Tipiracil Hydrochloride Combination-Induced Interstitial Pneumonia: A Case Report
Shun Nakazawa, Motoyasu Kato, Yuriko Terayama, Naho Sakamoto Matubara, Yoshihiko Sato, Ryoko Murashima, Daisuke Hayakawa, Shouichi Okamoto, Kazuhisa Takahashi Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, JapanCorrespondence: Shun Nakazawa, De...
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| Format: | Article |
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Dove Medical Press
2024-02-01
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| Series: | International Medical Case Reports Journal |
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| Online Access: | https://www.dovepress.com/trifluridine-and-tipiracil-hydrochloride-combination-induced-interstit-peer-reviewed-fulltext-article-IMCRJ |
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| author | Nakazawa S Kato M Terayama Y Sakamoto Matubara N Sato Y Murashima R Hayakawa D Okamoto S Takahashi K |
| author_facet | Nakazawa S Kato M Terayama Y Sakamoto Matubara N Sato Y Murashima R Hayakawa D Okamoto S Takahashi K |
| author_sort | Nakazawa S |
| collection | DOAJ |
| description | Shun Nakazawa, Motoyasu Kato, Yuriko Terayama, Naho Sakamoto Matubara, Yoshihiko Sato, Ryoko Murashima, Daisuke Hayakawa, Shouichi Okamoto, Kazuhisa Takahashi Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, JapanCorrespondence: Shun Nakazawa, Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo, 113-8431, Japan, Tel +81 3-3813-3111, Fax +81 3-3812-7560, Email shu-nakazawa@juntendo.ac.jpAbstract: We report a case of a 62-year-old male who was diagnosed with advanced rectal cancer. The attending gastro-enterologist initiated chemotherapy using capecitabine plus oxaliplatin and bevacizumab; however, this treatment regimen was discontinued, as the patient developed a skin rash. Once the skin rash improved, chemotherapy was re-initiated using a combination of trifluridine and tipiracil hydrochloride (TAS-102). The patient developed high fever and dyspnea 2 months after initiation of TAS-102. Chest high-resolution computed tomography showed bilateral diffuse ground glass opacities in all lung lobes with traction bronchiectasis. At this time, the gastro-enterologist consulted our department. The patient was put on non-invasive positive pressure ventilation due to worsening respiratory symptoms. The patient was suspected to develop TAS-102-induced interstitial pneumonia based on positive TAS-102 drug-induced lymphocyte stimulation test. The patient’s respiratory symptoms and radiological findings improved after corticosteroid treatment. The corticosteroid dose was gradually decreased by 5 mg. Thereafter, chemotherapy was re-initiated using different anti-cancer agents.Keywords: TAS-102, colorectal cancer, DAD, corticosteroid |
| first_indexed | 2024-03-08T04:12:04Z |
| format | Article |
| id | doaj.art-e68b1fb49c9d47d38471543db38593f9 |
| institution | Directory Open Access Journal |
| issn | 1179-142X |
| language | English |
| last_indexed | 2024-03-08T04:12:04Z |
| publishDate | 2024-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Medical Case Reports Journal |
| spelling | doaj.art-e68b1fb49c9d47d38471543db38593f92024-02-08T18:28:25ZengDove Medical PressInternational Medical Case Reports Journal1179-142X2024-02-01Volume 1710110490287Trifluridine and Tipiracil Hydrochloride Combination-Induced Interstitial Pneumonia: A Case ReportNakazawa SKato MTerayama YSakamoto Matubara NSato YMurashima RHayakawa DOkamoto STakahashi KShun Nakazawa, Motoyasu Kato, Yuriko Terayama, Naho Sakamoto Matubara, Yoshihiko Sato, Ryoko Murashima, Daisuke Hayakawa, Shouichi Okamoto, Kazuhisa Takahashi Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, JapanCorrespondence: Shun Nakazawa, Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo, 113-8431, Japan, Tel +81 3-3813-3111, Fax +81 3-3812-7560, Email shu-nakazawa@juntendo.ac.jpAbstract: We report a case of a 62-year-old male who was diagnosed with advanced rectal cancer. The attending gastro-enterologist initiated chemotherapy using capecitabine plus oxaliplatin and bevacizumab; however, this treatment regimen was discontinued, as the patient developed a skin rash. Once the skin rash improved, chemotherapy was re-initiated using a combination of trifluridine and tipiracil hydrochloride (TAS-102). The patient developed high fever and dyspnea 2 months after initiation of TAS-102. Chest high-resolution computed tomography showed bilateral diffuse ground glass opacities in all lung lobes with traction bronchiectasis. At this time, the gastro-enterologist consulted our department. The patient was put on non-invasive positive pressure ventilation due to worsening respiratory symptoms. The patient was suspected to develop TAS-102-induced interstitial pneumonia based on positive TAS-102 drug-induced lymphocyte stimulation test. The patient’s respiratory symptoms and radiological findings improved after corticosteroid treatment. The corticosteroid dose was gradually decreased by 5 mg. Thereafter, chemotherapy was re-initiated using different anti-cancer agents.Keywords: TAS-102, colorectal cancer, DAD, corticosteroidhttps://www.dovepress.com/trifluridine-and-tipiracil-hydrochloride-combination-induced-interstit-peer-reviewed-fulltext-article-IMCRJtas-102colorectal cancerdadcorticosteroid |
| spellingShingle | Nakazawa S Kato M Terayama Y Sakamoto Matubara N Sato Y Murashima R Hayakawa D Okamoto S Takahashi K Trifluridine and Tipiracil Hydrochloride Combination-Induced Interstitial Pneumonia: A Case Report International Medical Case Reports Journal tas-102 colorectal cancer dad corticosteroid |
| title | Trifluridine and Tipiracil Hydrochloride Combination-Induced Interstitial Pneumonia: A Case Report |
| title_full | Trifluridine and Tipiracil Hydrochloride Combination-Induced Interstitial Pneumonia: A Case Report |
| title_fullStr | Trifluridine and Tipiracil Hydrochloride Combination-Induced Interstitial Pneumonia: A Case Report |
| title_full_unstemmed | Trifluridine and Tipiracil Hydrochloride Combination-Induced Interstitial Pneumonia: A Case Report |
| title_short | Trifluridine and Tipiracil Hydrochloride Combination-Induced Interstitial Pneumonia: A Case Report |
| title_sort | trifluridine and tipiracil hydrochloride combination induced interstitial pneumonia a case report |
| topic | tas-102 colorectal cancer dad corticosteroid |
| url | https://www.dovepress.com/trifluridine-and-tipiracil-hydrochloride-combination-induced-interstit-peer-reviewed-fulltext-article-IMCRJ |
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