Design and synthesis of 3,4-seco-lupane triterpene derivatives to resist myocardial ischemia-reperfusion injury by inhibiting oxidative stress-mediated mitochondrial dysfunction via the PI3K/AKT/HIF-1α axis

Design and synthesis of 3,4-seco-lupane triterpene derivatives to resist myocardial ischemia-reperfusion injury by inhibiting oxidative stress-mediated mitochondrial dysfunction via the PI3K/AKT/HIF-1α axis

In this study, 86 new seco-lupane triterpenoid derivatives were designed, synthesized, and characterized, and their protective activities against ischemia-reperfusion injury were investigated in vitro and in vivo. Structure–activity relationship studies revealed that most target compounds could prot...

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Bibliographic Details
Main Authors: Hongbo Teng, Di Wu, Luo Lu, Chunyu Gao, Haohao Wang, Yan Zhao, Liyan Wang
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Biomedicine & Pharmacotherapy
Subjects:
3,4-seco-lupane triterpene derivatives
Myocardial ischemia-reperfusion injury
Mitochondrial dysfunction
Oxidative stress blocker
PI3K/AKT/HIF-1α
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223012507

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