USE OF TERIPARATIDE IN SURGICAL PLANNING FOR PATIENTS WITH OSTEOPOROSIS
ABSTRACT Currently, there are no guidelines for treating osteoporosis in spinal surgery. The rate of complications such as screw loosening, proximal junction kyphosis, cage subsidence, and loss of reduction in fractures is high. Objective: To evaluate the use of teriparatide and denosumab in plannin...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Coluna (SBC)
2023-10-01
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| Series: | Coluna/Columna |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1808-18512023000301000&lng=en&tlng=en |
| _version_ | 1797662898198151168 |
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| author | RICARDO CEPEDA JORDAN PEDRO LUIS BAZáN JOSé CARLOS SORIA ADARO |
| author_facet | RICARDO CEPEDA JORDAN PEDRO LUIS BAZáN JOSé CARLOS SORIA ADARO |
| author_sort | RICARDO CEPEDA JORDAN |
| collection | DOAJ |
| description | ABSTRACT Currently, there are no guidelines for treating osteoporosis in spinal surgery. The rate of complications such as screw loosening, proximal junction kyphosis, cage subsidence, and loss of reduction in fractures is high. Objective: To evaluate the use of teriparatide and denosumab in planning spinal surgery in an osteoporotic patient with degenerative pathology, emphasizing the fusion rate, bone mineral density, and decreased complications. Method: A systematic search was performed in medical reference databases for comparative studies of teriparatide and denosumab in spinal surgery to evaluate fusion, screw loosening, bone mineral density, and decrease in the incidence of vertebral fractures. χ2 was implemented for the statistical analysis, according to PRISMA (2020). Result: Fusion rate with teriparatide was 79.28% in the first six months, 95% CI (OR 2.62) and decreased screw loosening rate 81.9% 95% CI (OR 0.6). Increase in bone mineral density 15.5% OR 1.49 (0.77 - 2.86) and decrease in vertebral fracture rate 85.4% OR 0.5. Conclusions: Teriparatide and denosumab should be considered in perioperative spinal planning due to their effectiveness, synergism, and low adverse effects; to improve bone mineral density and decrease the rate of complications. Clinical, comparative, and statistically significant studies are required to confirm this. Level of Evidence II; Systematic Review and Meta-analysis. |
| first_indexed | 2024-03-11T19:06:46Z |
| format | Article |
| id | doaj.art-e68b53df97a442f9851b49c30bddedc0 |
| institution | Directory Open Access Journal |
| issn | 2177-014X |
| language | English |
| last_indexed | 2024-03-11T19:06:46Z |
| publishDate | 2023-10-01 |
| publisher | Sociedade Brasileira de Coluna (SBC) |
| record_format | Article |
| series | Coluna/Columna |
| spelling | doaj.art-e68b53df97a442f9851b49c30bddedc02023-10-10T07:41:10ZengSociedade Brasileira de Coluna (SBC)Coluna/Columna2177-014X2023-10-0122310.1590/s1808-185120222203270489USE OF TERIPARATIDE IN SURGICAL PLANNING FOR PATIENTS WITH OSTEOPOROSISRICARDO CEPEDA JORDANhttps://orcid.org/0000-0002-4007-2610PEDRO LUIS BAZáNhttps://orcid.org/0000-0003-0060-6558JOSé CARLOS SORIA ADAROhttps://orcid.org/0000-0002-9804-134XABSTRACT Currently, there are no guidelines for treating osteoporosis in spinal surgery. The rate of complications such as screw loosening, proximal junction kyphosis, cage subsidence, and loss of reduction in fractures is high. Objective: To evaluate the use of teriparatide and denosumab in planning spinal surgery in an osteoporotic patient with degenerative pathology, emphasizing the fusion rate, bone mineral density, and decreased complications. Method: A systematic search was performed in medical reference databases for comparative studies of teriparatide and denosumab in spinal surgery to evaluate fusion, screw loosening, bone mineral density, and decrease in the incidence of vertebral fractures. χ2 was implemented for the statistical analysis, according to PRISMA (2020). Result: Fusion rate with teriparatide was 79.28% in the first six months, 95% CI (OR 2.62) and decreased screw loosening rate 81.9% 95% CI (OR 0.6). Increase in bone mineral density 15.5% OR 1.49 (0.77 - 2.86) and decrease in vertebral fracture rate 85.4% OR 0.5. Conclusions: Teriparatide and denosumab should be considered in perioperative spinal planning due to their effectiveness, synergism, and low adverse effects; to improve bone mineral density and decrease the rate of complications. Clinical, comparative, and statistically significant studies are required to confirm this. Level of Evidence II; Systematic Review and Meta-analysis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1808-18512023000301000&lng=en&tlng=enOsteoporosisSurgical ProceduresOperativeSpineTeriparatideDenosumab |
| spellingShingle | RICARDO CEPEDA JORDAN PEDRO LUIS BAZáN JOSé CARLOS SORIA ADARO USE OF TERIPARATIDE IN SURGICAL PLANNING FOR PATIENTS WITH OSTEOPOROSIS Coluna/Columna Osteoporosis Surgical Procedures Operative Spine Teriparatide Denosumab |
| title | USE OF TERIPARATIDE IN SURGICAL PLANNING FOR PATIENTS WITH OSTEOPOROSIS |
| title_full | USE OF TERIPARATIDE IN SURGICAL PLANNING FOR PATIENTS WITH OSTEOPOROSIS |
| title_fullStr | USE OF TERIPARATIDE IN SURGICAL PLANNING FOR PATIENTS WITH OSTEOPOROSIS |
| title_full_unstemmed | USE OF TERIPARATIDE IN SURGICAL PLANNING FOR PATIENTS WITH OSTEOPOROSIS |
| title_short | USE OF TERIPARATIDE IN SURGICAL PLANNING FOR PATIENTS WITH OSTEOPOROSIS |
| title_sort | use of teriparatide in surgical planning for patients with osteoporosis |
| topic | Osteoporosis Surgical Procedures Operative Spine Teriparatide Denosumab |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1808-18512023000301000&lng=en&tlng=en |
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