In silico data analyses of recombinases GdDMC1A and GdDMC1B from Giardia duodenalis
Giardia duodenalis is a worldwide protozoa known causing diarrhea in all vertebrates, humans among these. Homologous recombination is a mechanism that provides genomic stability. Two putative recombinases were identified in G. duodenalis genome: GdDMC1A and GdDMC1B. In this article, we describe the...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-12-01
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| Series: | Data in Brief |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340916305327 |
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| author | Ana Laura Torres-Huerta Rosa María Martínez-Miguel María Luisa Bazán-Tejeda Rosa María Bermúdez-Cruz |
| author_facet | Ana Laura Torres-Huerta Rosa María Martínez-Miguel María Luisa Bazán-Tejeda Rosa María Bermúdez-Cruz |
| author_sort | Ana Laura Torres-Huerta |
| collection | DOAJ |
| description | Giardia duodenalis is a worldwide protozoa known causing diarrhea in all vertebrates, humans among these. Homologous recombination is a mechanism that provides genomic stability. Two putative recombinases were identified in G. duodenalis genome: GdDMC1A and GdDMC1B. In this article, we describe the identification of conserved domains in GdDMC1A and GdDMC1B, such as: DNA binding domains (Helix-turn-helix motif, loops 1 and 2) and an ATPcap and Walker A and B motifs associated with ATP binding and hydrolysis, phylogenetic analyses among assemblages and three-dimensional structure modeling of these recombinases using bioinformatics tools. Also, experimental data is described about LD50 determination for ionizing radiation in trophozoites of G. duodenalis. Additionally, as recombinases, GdDMC1A and GdDMC1B were used to rescue a defective Saccharomyces cerevisiae Δ rad51 strain under genotoxic conditions and data is described.
The data described here are related to the research article entitled “Characterization of recombinase DMC1B and its functional role as Rad51 in DNA damage repair in Giardia duodenalis trophozoites” (Torres-Huerta et al.,) [1]. |
| first_indexed | 2024-12-11T22:28:59Z |
| format | Article |
| id | doaj.art-e68bc34c682d4281a2f6171256998691 |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-12-11T22:28:59Z |
| publishDate | 2016-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-e68bc34c682d4281a2f61712569986912022-12-22T00:48:12ZengElsevierData in Brief2352-34092016-12-019C23624410.1016/j.dib.2016.08.031In silico data analyses of recombinases GdDMC1A and GdDMC1B from Giardia duodenalisAna Laura Torres-HuertaRosa María Martínez-MiguelMaría Luisa Bazán-TejedaRosa María Bermúdez-CruzGiardia duodenalis is a worldwide protozoa known causing diarrhea in all vertebrates, humans among these. Homologous recombination is a mechanism that provides genomic stability. Two putative recombinases were identified in G. duodenalis genome: GdDMC1A and GdDMC1B. In this article, we describe the identification of conserved domains in GdDMC1A and GdDMC1B, such as: DNA binding domains (Helix-turn-helix motif, loops 1 and 2) and an ATPcap and Walker A and B motifs associated with ATP binding and hydrolysis, phylogenetic analyses among assemblages and three-dimensional structure modeling of these recombinases using bioinformatics tools. Also, experimental data is described about LD50 determination for ionizing radiation in trophozoites of G. duodenalis. Additionally, as recombinases, GdDMC1A and GdDMC1B were used to rescue a defective Saccharomyces cerevisiae Δ rad51 strain under genotoxic conditions and data is described. The data described here are related to the research article entitled “Characterization of recombinase DMC1B and its functional role as Rad51 in DNA damage repair in Giardia duodenalis trophozoites” (Torres-Huerta et al.,) [1].http://www.sciencedirect.com/science/article/pii/S2352340916305327In silico analysesDMC1B and DMC1A3D structure predictionDL50 for ionizing radiation |
| spellingShingle | Ana Laura Torres-Huerta Rosa María Martínez-Miguel María Luisa Bazán-Tejeda Rosa María Bermúdez-Cruz In silico data analyses of recombinases GdDMC1A and GdDMC1B from Giardia duodenalis Data in Brief In silico analyses DMC1B and DMC1A 3D structure prediction DL50 for ionizing radiation |
| title | In silico data analyses of recombinases GdDMC1A and GdDMC1B from Giardia duodenalis |
| title_full | In silico data analyses of recombinases GdDMC1A and GdDMC1B from Giardia duodenalis |
| title_fullStr | In silico data analyses of recombinases GdDMC1A and GdDMC1B from Giardia duodenalis |
| title_full_unstemmed | In silico data analyses of recombinases GdDMC1A and GdDMC1B from Giardia duodenalis |
| title_short | In silico data analyses of recombinases GdDMC1A and GdDMC1B from Giardia duodenalis |
| title_sort | in silico data analyses of recombinases gddmc1a and gddmc1b from giardia duodenalis |
| topic | In silico analyses DMC1B and DMC1A 3D structure prediction DL50 for ionizing radiation |
| url | http://www.sciencedirect.com/science/article/pii/S2352340916305327 |
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