Comparison of the rapidity of SARS-CoV-2 immune responses between primary and booster vaccination for COVID-19
Background/Aims The rapidity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific memory B or T cell response in vaccinated individuals is important for our understanding of immunopathogenesis of coronavirus disease 2019 (COVID-19). We therefore compared the timing of adequate im...
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| Formato: | Artigo |
| Idioma: | English |
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The Korean Association of Internal Medicine
2022-11-01
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| Colecção: | The Korean Journal of Internal Medicine |
| Assuntos: | |
| Acesso em linha: | http://kjim.org/upload/pdf/kjim-2022-173.pdf |
| _version_ | 1828092890622984192 |
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| author | Ji Yeun Kim Ji-Soo Kwon Hye Hee Cha So Yun Lim Seongman Bae Sung-Han Kim |
| author_facet | Ji Yeun Kim Ji-Soo Kwon Hye Hee Cha So Yun Lim Seongman Bae Sung-Han Kim |
| author_sort | Ji Yeun Kim |
| collection | DOAJ |
| description | Background/Aims The rapidity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific memory B or T cell response in vaccinated individuals is important for our understanding of immunopathogenesis of coronavirus disease 2019 (COVID-19). We therefore compared the timing of adequate immune responses between the first and booster doses of COVID-19 vaccines in infection-naïve healthcare workers. Methods We enrolled healthcare workers who received two doses of either the BNT162b2 vaccine or the ChAdOx1 vaccine, all of whom received the BNT162b2 vaccine as the booster (the third) dose. Spike 1 (S1)-immunoglobulin G (IgG) antibodies and interferon gamma producing T cell responses were measured at 0, 7, 14, and 21 days after the first dose, and at 0 and between 2 to 7 days after the booster dose. Results After the first-dose vaccination, the S1-IgG antibody responses were elicited within 14 days in the BNT162b2 group and within 21 days in the ChAdOx1 group. After the booster dose, the S1-IgG antibody responses were elicited within 5 days in both groups. The SARS-CoV-2-specific T cell responses appeared at 7 days after the first dose and at 4 days after the booster dose. Conclusions SARS-CoV-2-specific immune responses by memory B cells and T cells may be expected to appear around 4 to 5 days after the booster dose. |
| first_indexed | 2024-04-11T06:36:33Z |
| format | Article |
| id | doaj.art-e68c66a8017e47e096d6307634dbe1e7 |
| institution | Directory Open Access Journal |
| issn | 1226-3303 2005-6648 |
| language | English |
| last_indexed | 2024-04-11T06:36:33Z |
| publishDate | 2022-11-01 |
| publisher | The Korean Association of Internal Medicine |
| record_format | Article |
| series | The Korean Journal of Internal Medicine |
| spelling | doaj.art-e68c66a8017e47e096d6307634dbe1e72022-12-22T04:39:41ZengThe Korean Association of Internal MedicineThe Korean Journal of Internal Medicine1226-33032005-66482022-11-013761234124010.3904/kjim.2022.173170729Comparison of the rapidity of SARS-CoV-2 immune responses between primary and booster vaccination for COVID-19Ji Yeun Kim0Ji-Soo Kwon1Hye Hee Cha2So Yun Lim3Seongman Bae4Sung-Han Kim5Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaDepartment of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaDepartment of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaDepartment of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaDepartment of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaDepartment of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaBackground/Aims The rapidity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific memory B or T cell response in vaccinated individuals is important for our understanding of immunopathogenesis of coronavirus disease 2019 (COVID-19). We therefore compared the timing of adequate immune responses between the first and booster doses of COVID-19 vaccines in infection-naïve healthcare workers. Methods We enrolled healthcare workers who received two doses of either the BNT162b2 vaccine or the ChAdOx1 vaccine, all of whom received the BNT162b2 vaccine as the booster (the third) dose. Spike 1 (S1)-immunoglobulin G (IgG) antibodies and interferon gamma producing T cell responses were measured at 0, 7, 14, and 21 days after the first dose, and at 0 and between 2 to 7 days after the booster dose. Results After the first-dose vaccination, the S1-IgG antibody responses were elicited within 14 days in the BNT162b2 group and within 21 days in the ChAdOx1 group. After the booster dose, the S1-IgG antibody responses were elicited within 5 days in both groups. The SARS-CoV-2-specific T cell responses appeared at 7 days after the first dose and at 4 days after the booster dose. Conclusions SARS-CoV-2-specific immune responses by memory B cells and T cells may be expected to appear around 4 to 5 days after the booster dose.http://kjim.org/upload/pdf/kjim-2022-173.pdfantibody formationprimarysecondarycovid-19 vaccines |
| spellingShingle | Ji Yeun Kim Ji-Soo Kwon Hye Hee Cha So Yun Lim Seongman Bae Sung-Han Kim Comparison of the rapidity of SARS-CoV-2 immune responses between primary and booster vaccination for COVID-19 The Korean Journal of Internal Medicine antibody formation primary secondary covid-19 vaccines |
| title | Comparison of the rapidity of SARS-CoV-2 immune responses between primary and booster vaccination for COVID-19 |
| title_full | Comparison of the rapidity of SARS-CoV-2 immune responses between primary and booster vaccination for COVID-19 |
| title_fullStr | Comparison of the rapidity of SARS-CoV-2 immune responses between primary and booster vaccination for COVID-19 |
| title_full_unstemmed | Comparison of the rapidity of SARS-CoV-2 immune responses between primary and booster vaccination for COVID-19 |
| title_short | Comparison of the rapidity of SARS-CoV-2 immune responses between primary and booster vaccination for COVID-19 |
| title_sort | comparison of the rapidity of sars cov 2 immune responses between primary and booster vaccination for covid 19 |
| topic | antibody formation primary secondary covid-19 vaccines |
| url | http://kjim.org/upload/pdf/kjim-2022-173.pdf |
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