A GLP-1 Analog Liraglutide Reduces Intimal Hyperplasia After Coronary Stent Implantation via Regulation of Glycemic Variability and NLRP3 Inflammasome/IL-10 Signaling in Diabetic Swine

A GLP-1 Analog Liraglutide Reduces Intimal Hyperplasia After Coronary Stent Implantation via Regulation of Glycemic Variability and NLRP3 Inflammasome/IL-10 Signaling in Diabetic Swine

ObjectiveThis study aimed to explore whether treatment with the glucagon-like peptide-1 (GLP-1) analog liraglutide reduces intimal hyperplasia after coronary stent implantation via regulation of glycemic variability, the NLRP3 inflammasome, and IL-10 in diabetic swine.MethodsFifteen pigs were divide...

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Bibliographic Details
Main Authors: Jinggang Xia, Qinxue Li, Yayun Liu, Quanxin Ren, Jinhuan Gao, Yi Tian, Jubo Li, Baojie Zhang, Haichen Sun, Shuang Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Pharmacology
Subjects:
liraglutide
intimal hyperplasia
glycemic variability
NOD-like receptor family pyrin domain containing 3
interleukin-10
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00372/full

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