Rare case report: a case of histological type transformation of lung cancer caused by neoadjuvant immunotherapy
Lung cancer remains the leading cause of cancer-related mortality, with 1.8 million deaths per year. Small cell lung cancer and non-small cell lung cancer (NSCLC) are the main cancer types. Approximately 85% of cases are NSCLC, including adenocarcinoma, squamous cell carcinoma, and large cell carcin...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1329152/full |
| _version_ | 1797307031347003392 |
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| author | Quanqing Li Guangxin Zhang Hao Yang Jindong Li |
| author_facet | Quanqing Li Guangxin Zhang Hao Yang Jindong Li |
| author_sort | Quanqing Li |
| collection | DOAJ |
| description | Lung cancer remains the leading cause of cancer-related mortality, with 1.8 million deaths per year. Small cell lung cancer and non-small cell lung cancer (NSCLC) are the main cancer types. Approximately 85% of cases are NSCLC, including adenocarcinoma, squamous cell carcinoma, and large cell carcinoma. In this reported treatment case, the tumor histological type changed after targeted therapy, which has not been previously well documented. The patient was a 67-year-old woman diagnosed with squamous cell carcinoma via bronchoscopy. She received five neoadjuvant immune monotherapies. The lesion shrank but then progressed, with a diagnosis of small cell carcinoma via bronchoscopy. This finding suggests that tumor acquisition of resistance as manifested by cancer-type changes needs consideration and study in the application of this particular type of immunotherapy. |
| first_indexed | 2024-03-08T00:51:27Z |
| format | Article |
| id | doaj.art-e68dd898add04f2f8303d4490300e504 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-08T00:51:27Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-e68dd898add04f2f8303d4490300e5042024-02-15T04:41:10ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-02-011410.3389/fonc.2024.13291521329152Rare case report: a case of histological type transformation of lung cancer caused by neoadjuvant immunotherapyQuanqing LiGuangxin ZhangHao YangJindong LiLung cancer remains the leading cause of cancer-related mortality, with 1.8 million deaths per year. Small cell lung cancer and non-small cell lung cancer (NSCLC) are the main cancer types. Approximately 85% of cases are NSCLC, including adenocarcinoma, squamous cell carcinoma, and large cell carcinoma. In this reported treatment case, the tumor histological type changed after targeted therapy, which has not been previously well documented. The patient was a 67-year-old woman diagnosed with squamous cell carcinoma via bronchoscopy. She received five neoadjuvant immune monotherapies. The lesion shrank but then progressed, with a diagnosis of small cell carcinoma via bronchoscopy. This finding suggests that tumor acquisition of resistance as manifested by cancer-type changes needs consideration and study in the application of this particular type of immunotherapy.https://www.frontiersin.org/articles/10.3389/fonc.2024.1329152/fullhistological type transformationneoadjuvant immunotherapysmall cell lung cancerdrug resistancesquamous cell lung carcinoma |
| spellingShingle | Quanqing Li Guangxin Zhang Hao Yang Jindong Li Rare case report: a case of histological type transformation of lung cancer caused by neoadjuvant immunotherapy Frontiers in Oncology histological type transformation neoadjuvant immunotherapy small cell lung cancer drug resistance squamous cell lung carcinoma |
| title | Rare case report: a case of histological type transformation of lung cancer caused by neoadjuvant immunotherapy |
| title_full | Rare case report: a case of histological type transformation of lung cancer caused by neoadjuvant immunotherapy |
| title_fullStr | Rare case report: a case of histological type transformation of lung cancer caused by neoadjuvant immunotherapy |
| title_full_unstemmed | Rare case report: a case of histological type transformation of lung cancer caused by neoadjuvant immunotherapy |
| title_short | Rare case report: a case of histological type transformation of lung cancer caused by neoadjuvant immunotherapy |
| title_sort | rare case report a case of histological type transformation of lung cancer caused by neoadjuvant immunotherapy |
| topic | histological type transformation neoadjuvant immunotherapy small cell lung cancer drug resistance squamous cell lung carcinoma |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1329152/full |
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