Interleukin 18 in the CNS
<p>Abstract</p> <p>Interleukin (IL)-18 is a cytokine isolated as an important modulator of immune responses and subsequently shown to be pleiotropic. IL-18 and its receptors are expressed in the central nervous system (CNS) where they participate in neuroinflammatory/neurodegenerat...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2010-01-01
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| Series: | Journal of Neuroinflammation |
| Online Access: | http://www.jneuroinflammation.com/content/7/1/9 |
| _version_ | 1818790236023422976 |
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| author | Sugama Shuei Cervia Davide Alboni Silvia Conti Bruno |
| author_facet | Sugama Shuei Cervia Davide Alboni Silvia Conti Bruno |
| author_sort | Sugama Shuei |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Interleukin (IL)-18 is a cytokine isolated as an important modulator of immune responses and subsequently shown to be pleiotropic. IL-18 and its receptors are expressed in the central nervous system (CNS) where they participate in neuroinflammatory/neurodegenerative processes but also influence homeostasis and behavior. Work on IL-18 null mice, the localization of the IL-18 receptor complex in neurons and the neuronal expression of decoy isoforms of the receptor subunits are beginning to reveal the complexity and the significance of the IL-18 system in the CNS. This review summarizes current knowledge on the central role of IL-18 in health and disease.</p> |
| first_indexed | 2024-12-18T14:52:15Z |
| format | Article |
| id | doaj.art-e68e46d9b54940deb54f33d3d2555580 |
| institution | Directory Open Access Journal |
| issn | 1742-2094 |
| language | English |
| last_indexed | 2024-12-18T14:52:15Z |
| publishDate | 2010-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Neuroinflammation |
| spelling | doaj.art-e68e46d9b54940deb54f33d3d25555802022-12-21T21:04:08ZengBMCJournal of Neuroinflammation1742-20942010-01-0171910.1186/1742-2094-7-9Interleukin 18 in the CNSSugama ShueiCervia DavideAlboni SilviaConti Bruno<p>Abstract</p> <p>Interleukin (IL)-18 is a cytokine isolated as an important modulator of immune responses and subsequently shown to be pleiotropic. IL-18 and its receptors are expressed in the central nervous system (CNS) where they participate in neuroinflammatory/neurodegenerative processes but also influence homeostasis and behavior. Work on IL-18 null mice, the localization of the IL-18 receptor complex in neurons and the neuronal expression of decoy isoforms of the receptor subunits are beginning to reveal the complexity and the significance of the IL-18 system in the CNS. This review summarizes current knowledge on the central role of IL-18 in health and disease.</p>http://www.jneuroinflammation.com/content/7/1/9 |
| spellingShingle | Sugama Shuei Cervia Davide Alboni Silvia Conti Bruno Interleukin 18 in the CNS Journal of Neuroinflammation |
| title | Interleukin 18 in the CNS |
| title_full | Interleukin 18 in the CNS |
| title_fullStr | Interleukin 18 in the CNS |
| title_full_unstemmed | Interleukin 18 in the CNS |
| title_short | Interleukin 18 in the CNS |
| title_sort | interleukin 18 in the cns |
| url | http://www.jneuroinflammation.com/content/7/1/9 |
| work_keys_str_mv | AT sugamashuei interleukin18inthecns AT cerviadavide interleukin18inthecns AT albonisilvia interleukin18inthecns AT contibruno interleukin18inthecns |