Ciprofloxacin-Induced Anaphylactic Reaction Followed by Negative Provocation Test in Response to Levofloxacin: A Case Report
Fluoroquinolones are a commonly prescribed class of antibiotics due to their broad spectrum of antimicrobial activity, favorable pharmacokinetic properties, ability to switch from parenteral to oral administration, and global availability. After beta-lactams, they are the second most common antibiot...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/59/10/1784 |
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| author | Marija Kurtov Paula Kilić Lucija Ikić Karlo Kurtov Gordan Dorčić Marko Vodanović Marinko Artuković Marina Ikić Matijašević |
| author_facet | Marija Kurtov Paula Kilić Lucija Ikić Karlo Kurtov Gordan Dorčić Marko Vodanović Marinko Artuković Marina Ikić Matijašević |
| author_sort | Marija Kurtov |
| collection | DOAJ |
| description | Fluoroquinolones are a commonly prescribed class of antibiotics due to their broad spectrum of antimicrobial activity, favorable pharmacokinetic properties, ability to switch from parenteral to oral administration, and global availability. After beta-lactams, they are the second most common antibiotic class associated with drug allergies. The mechanism of fluoroquinolone-induced hypersensitivity reactions has not yet been fully understood, so the true incidence of hypersensitivity reactions remains unknown. Cross-reactivity between fluoroquinolones has been the subject of conflicting and limited clinical research. Due to their similar chemical structure, some argue for close cross-reactivity within the group. However, recent studies have produced contradictory results. We present the case of a young patient who had an anaphylactic reaction to ciprofloxacin but was tolerant to levofloxacin, as determined via a skin prick test followed by a drug provocation test. Our findings support the notion that there is little cross-reactivity between fluoroquinolones. Consequently, exposure to another fluoroquinolone in a hospital setting may be beneficial, particularly for patients who lack adequate antibiotic alternatives. However, additional research on this subject is required. |
| first_indexed | 2024-03-10T21:05:15Z |
| format | Article |
| id | doaj.art-e68f433c9c3447459c6b46028cf1af92 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T21:05:15Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-e68f433c9c3447459c6b46028cf1af922023-11-19T17:17:10ZengMDPI AGMedicina1010-660X1648-91442023-10-015910178410.3390/medicina59101784Ciprofloxacin-Induced Anaphylactic Reaction Followed by Negative Provocation Test in Response to Levofloxacin: A Case ReportMarija Kurtov0Paula Kilić1Lucija Ikić2Karlo Kurtov3Gordan Dorčić4Marko Vodanović5Marinko Artuković6Marina Ikić Matijašević7Department of Clinical Pharmacology and Toxicology, University Hospital Sveti Duh, 10000 Zagreb, CroatiaDepartment of Clinical Immunology, Rheumatology, and Pulmonology, University Hospital Sveti Duh, 10000 Zagreb, CroatiaDepartment of Anatomy and Physiology, University of Applied Health Sciences, 10000 Zagreb, CroatiaDepartment of Nephrology and Dialysis, University Hospital Merkur, 10000 Zagreb, CroatiaDepartment of Nephrology and Dialysis, University Hospital Sveti Duh, 10000 Zagreb, CroatiaDivision of Gastroenterology and Hepatology, University Hospital Sveti Duh, 10000 Zagreb, CroatiaDepartment of Clinical Immunology, Rheumatology, and Pulmonology, University Hospital Sveti Duh, 10000 Zagreb, CroatiaDepartment of Clinical Immunology, Rheumatology, and Pulmonology, University Hospital Sveti Duh, 10000 Zagreb, CroatiaFluoroquinolones are a commonly prescribed class of antibiotics due to their broad spectrum of antimicrobial activity, favorable pharmacokinetic properties, ability to switch from parenteral to oral administration, and global availability. After beta-lactams, they are the second most common antibiotic class associated with drug allergies. The mechanism of fluoroquinolone-induced hypersensitivity reactions has not yet been fully understood, so the true incidence of hypersensitivity reactions remains unknown. Cross-reactivity between fluoroquinolones has been the subject of conflicting and limited clinical research. Due to their similar chemical structure, some argue for close cross-reactivity within the group. However, recent studies have produced contradictory results. We present the case of a young patient who had an anaphylactic reaction to ciprofloxacin but was tolerant to levofloxacin, as determined via a skin prick test followed by a drug provocation test. Our findings support the notion that there is little cross-reactivity between fluoroquinolones. Consequently, exposure to another fluoroquinolone in a hospital setting may be beneficial, particularly for patients who lack adequate antibiotic alternatives. However, additional research on this subject is required.https://www.mdpi.com/1648-9144/59/10/1784fluoroquinolonescross-reactivityallergyciprofloxacinlevofloxacindrug provocation test |
| spellingShingle | Marija Kurtov Paula Kilić Lucija Ikić Karlo Kurtov Gordan Dorčić Marko Vodanović Marinko Artuković Marina Ikić Matijašević Ciprofloxacin-Induced Anaphylactic Reaction Followed by Negative Provocation Test in Response to Levofloxacin: A Case Report Medicina fluoroquinolones cross-reactivity allergy ciprofloxacin levofloxacin drug provocation test |
| title | Ciprofloxacin-Induced Anaphylactic Reaction Followed by Negative Provocation Test in Response to Levofloxacin: A Case Report |
| title_full | Ciprofloxacin-Induced Anaphylactic Reaction Followed by Negative Provocation Test in Response to Levofloxacin: A Case Report |
| title_fullStr | Ciprofloxacin-Induced Anaphylactic Reaction Followed by Negative Provocation Test in Response to Levofloxacin: A Case Report |
| title_full_unstemmed | Ciprofloxacin-Induced Anaphylactic Reaction Followed by Negative Provocation Test in Response to Levofloxacin: A Case Report |
| title_short | Ciprofloxacin-Induced Anaphylactic Reaction Followed by Negative Provocation Test in Response to Levofloxacin: A Case Report |
| title_sort | ciprofloxacin induced anaphylactic reaction followed by negative provocation test in response to levofloxacin a case report |
| topic | fluoroquinolones cross-reactivity allergy ciprofloxacin levofloxacin drug provocation test |
| url | https://www.mdpi.com/1648-9144/59/10/1784 |
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