Cyclodextrin Metal-Organic Framework as a Broad-Spectrum Potential Delivery Vehicle for the Gasotransmitters
The important role of gasotransmitters in physiology and pathophysiology suggest employing gasotransmitters for biomedical treatment. Unfortunately, the difficulty in storage and controlled delivery of these gaseous molecules hindered the development of effective gasotransmitters-based therapies. Th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/2/852 |
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| author | Li-Guo Liao Duo Ke Guo-Chen Li Sheng Zhang Bang-Jing Li |
| author_facet | Li-Guo Liao Duo Ke Guo-Chen Li Sheng Zhang Bang-Jing Li |
| author_sort | Li-Guo Liao |
| collection | DOAJ |
| description | The important role of gasotransmitters in physiology and pathophysiology suggest employing gasotransmitters for biomedical treatment. Unfortunately, the difficulty in storage and controlled delivery of these gaseous molecules hindered the development of effective gasotransmitters-based therapies. The design of a safe, facile, and wide-scale method to delivery multiple gasotransmitters is a great challenge. Herein, we use an ultrasonic assisted preparation γ-cyclodextrin metal organic framework (γ-CD-MOF) as a broad-spectrum delivery vehicle for various gasotransmitters, such as SO<sub>2</sub>, NO, and H<sub>2</sub>S. The release rate of gasotransmitters could be tuned by modifying the γ-CD-MOF with different Pluronics. The biological relevance of the exogenous gasotransmitters produced by this method is evidenced by the DNA cleavage ability and the anti-inflammatory effects. Furthermore, the γ-CD-MOF composed of food-grade γ-CD and nontoxic metal salts shows good biocompatibility and particle size (180 nm). Therefore, γ-CD-MOF is expected to be an excellent tool for the study of co-delivery and cooperative therapy of gasotransmitters. |
| first_indexed | 2024-03-09T11:33:59Z |
| format | Article |
| id | doaj.art-e68f8bc8ef1f490ba24e94c1c4fd5b64 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T11:33:59Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-e68f8bc8ef1f490ba24e94c1c4fd5b642023-11-30T23:45:50ZengMDPI AGMolecules1420-30492023-01-0128285210.3390/molecules28020852Cyclodextrin Metal-Organic Framework as a Broad-Spectrum Potential Delivery Vehicle for the GasotransmittersLi-Guo Liao0Duo Ke1Guo-Chen Li2Sheng Zhang3Bang-Jing Li4Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, ChinaKey Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, ChinaState Key Laboratory of Polymer Materials Engineering, Polymer Research Institute of Sichuan University, Chengdu 610065, ChinaState Key Laboratory of Polymer Materials Engineering, Polymer Research Institute of Sichuan University, Chengdu 610065, ChinaKey Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, ChinaThe important role of gasotransmitters in physiology and pathophysiology suggest employing gasotransmitters for biomedical treatment. Unfortunately, the difficulty in storage and controlled delivery of these gaseous molecules hindered the development of effective gasotransmitters-based therapies. The design of a safe, facile, and wide-scale method to delivery multiple gasotransmitters is a great challenge. Herein, we use an ultrasonic assisted preparation γ-cyclodextrin metal organic framework (γ-CD-MOF) as a broad-spectrum delivery vehicle for various gasotransmitters, such as SO<sub>2</sub>, NO, and H<sub>2</sub>S. The release rate of gasotransmitters could be tuned by modifying the γ-CD-MOF with different Pluronics. The biological relevance of the exogenous gasotransmitters produced by this method is evidenced by the DNA cleavage ability and the anti-inflammatory effects. Furthermore, the γ-CD-MOF composed of food-grade γ-CD and nontoxic metal salts shows good biocompatibility and particle size (180 nm). Therefore, γ-CD-MOF is expected to be an excellent tool for the study of co-delivery and cooperative therapy of gasotransmitters.https://www.mdpi.com/1420-3049/28/2/852γ-CD-MOFgasotransmittersultrasound-assisted methoddelivery carrierbroad-spectrum |
| spellingShingle | Li-Guo Liao Duo Ke Guo-Chen Li Sheng Zhang Bang-Jing Li Cyclodextrin Metal-Organic Framework as a Broad-Spectrum Potential Delivery Vehicle for the Gasotransmitters Molecules γ-CD-MOF gasotransmitters ultrasound-assisted method delivery carrier broad-spectrum |
| title | Cyclodextrin Metal-Organic Framework as a Broad-Spectrum Potential Delivery Vehicle for the Gasotransmitters |
| title_full | Cyclodextrin Metal-Organic Framework as a Broad-Spectrum Potential Delivery Vehicle for the Gasotransmitters |
| title_fullStr | Cyclodextrin Metal-Organic Framework as a Broad-Spectrum Potential Delivery Vehicle for the Gasotransmitters |
| title_full_unstemmed | Cyclodextrin Metal-Organic Framework as a Broad-Spectrum Potential Delivery Vehicle for the Gasotransmitters |
| title_short | Cyclodextrin Metal-Organic Framework as a Broad-Spectrum Potential Delivery Vehicle for the Gasotransmitters |
| title_sort | cyclodextrin metal organic framework as a broad spectrum potential delivery vehicle for the gasotransmitters |
| topic | γ-CD-MOF gasotransmitters ultrasound-assisted method delivery carrier broad-spectrum |
| url | https://www.mdpi.com/1420-3049/28/2/852 |
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