Artesunate attenuates traumatic brain injury-induced impairments in rats
Blood–brain barrier (BBB) dysfunction and neuroinflammation induced by traumatic brain injuries (TBIs) cause a succession of secondary brain damage events and finally lead to a massive and progressive cerebral neuronal destruction. Artesunate, a semisynthetic artemisinin derivative, is a potential c...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2020-09-01
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| Series: | Translational Neuroscience |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/tnsci-2020-0136 |
| _version_ | 1811213379974463488 |
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| author | Zhou Zhike Hou Jun Li Qinghua |
| author_facet | Zhou Zhike Hou Jun Li Qinghua |
| author_sort | Zhou Zhike |
| collection | DOAJ |
| description | Blood–brain barrier (BBB) dysfunction and neuroinflammation induced by traumatic brain injuries (TBIs) cause a succession of secondary brain damage events and finally lead to a massive and progressive cerebral neuronal destruction. Artesunate, a semisynthetic artemisinin derivative, is a potential candidate for the management of cerebral damage induced by TBI due to its protective function to BBB and cerebral neurons. |
| first_indexed | 2024-04-12T05:45:49Z |
| format | Article |
| id | doaj.art-e6920508003f47bd80e47e164b0a8faa |
| institution | Directory Open Access Journal |
| issn | 2081-6936 |
| language | English |
| last_indexed | 2024-04-12T05:45:49Z |
| publishDate | 2020-09-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Translational Neuroscience |
| spelling | doaj.art-e6920508003f47bd80e47e164b0a8faa2022-12-22T03:45:28ZengDe GruyterTranslational Neuroscience2081-69362020-09-0111130931810.1515/tnsci-2020-0136tnsci-2020-0136Artesunate attenuates traumatic brain injury-induced impairments in ratsZhou Zhike0Hou Jun1Li Qinghua2Department of Dermatology, Qingdao Municipal Hospital, No. 21 Anhui Road, Qingdao 266001, Shandong, ChinaDepartment of Dermatology, Qingdao Municipal Hospital, No. 21 Anhui Road, Qingdao 266001, Shandong, ChinaDepartment of Dermatology, Qingdao Municipal Hospital, No. 21 Anhui Road, Qingdao 266001, Shandong, ChinaBlood–brain barrier (BBB) dysfunction and neuroinflammation induced by traumatic brain injuries (TBIs) cause a succession of secondary brain damage events and finally lead to a massive and progressive cerebral neuronal destruction. Artesunate, a semisynthetic artemisinin derivative, is a potential candidate for the management of cerebral damage induced by TBI due to its protective function to BBB and cerebral neurons.https://doi.org/10.1515/tnsci-2020-0136artesunatetraumatic brain injuriesblood–brain barrierinflammation |
| spellingShingle | Zhou Zhike Hou Jun Li Qinghua Artesunate attenuates traumatic brain injury-induced impairments in rats Translational Neuroscience artesunate traumatic brain injuries blood–brain barrier inflammation |
| title | Artesunate attenuates traumatic brain injury-induced impairments in rats |
| title_full | Artesunate attenuates traumatic brain injury-induced impairments in rats |
| title_fullStr | Artesunate attenuates traumatic brain injury-induced impairments in rats |
| title_full_unstemmed | Artesunate attenuates traumatic brain injury-induced impairments in rats |
| title_short | Artesunate attenuates traumatic brain injury-induced impairments in rats |
| title_sort | artesunate attenuates traumatic brain injury induced impairments in rats |
| topic | artesunate traumatic brain injuries blood–brain barrier inflammation |
| url | https://doi.org/10.1515/tnsci-2020-0136 |
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