LPA disruption with AAV-CRISPR potently lowers plasma apo(a) in transgenic mouse model: A proof-of-concept study
Lipoprotein(a) (Lp(a)) represents a unique subclass of circulating lipoprotein particles and consists of an apolipoprotein(a) (apo(a)) molecule covalently bound to apolipoprotein B-100. The metabolism of Lp(a) particles is distinct from that of low-density lipoprotein (LDL) cholesterol, and currentl...
Main Authors: | Alexandria M. Doerfler, So Hyun Park, Julia M. Assini, Amer Youssef, Lavanya Saxena, Adam B. Yaseen, Marco De Giorgi, Marcel Chuecos, Ayrea E. Hurley, Ang Li, Santica M. Marcovina, Gang Bao, Michael B. Boffa, Marlys L. Koschinsky, William R. Lagor |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2022-12-01
|
Series: | Molecular Therapy: Methods & Clinical Development |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2329050122001516 |
Similar Items
-
Assessment of Apolipoprotein(a) Isoform Size Using Phenotypic and Genotypic Methods
by: Federica Fogacci, et al.
Published: (2023-09-01) -
Descriptor-based Fitting of LPA3 Inhibitors into a Single Predictive Mathematical Model
by: Olaposi Idowu Omotuyi, et al.
Published: (2014-10-01) -
The kringle IV type 2 domain variant 4925G>A causes the elusive association signal of the LPA pentanucleotide repeat
by: Rebecca Grüneis, et al.
Published: (2022-12-01) -
Lipoprotein(a) induces caspase-1 activation and IL-1 signaling in human macrophages
by: Martina B. Lorey, et al.
Published: (2023-05-01) -
Measurement of leukocyte-platelet aggregates (LPA) by FACS: a comparative analysis
by: Christina Polasky, et al.
Published: (2021-02-01)