Pituitary Adenylate Cyclase-Activating Polypeptide: A Potent Therapeutic Agent in Oxidative Stress
Stroke is a life-threatening condition that is characterized by secondary cell death processes that occur after the initial disruption of blood flow to the brain. The inability of endogenous repair mechanisms to sufficiently support functional recovery in stroke patients and the inadequate treatment...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/10/3/354 |
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| author | Nadia Sadanandan Blaise Cozene You Jeong Park Jeffrey Farooq Chase Kingsbury Zhen-Jie Wang Alexa Moscatello Madeline Saft Justin Cho Bella Gonzales-Portillo Cesar V. Borlongan |
| author_facet | Nadia Sadanandan Blaise Cozene You Jeong Park Jeffrey Farooq Chase Kingsbury Zhen-Jie Wang Alexa Moscatello Madeline Saft Justin Cho Bella Gonzales-Portillo Cesar V. Borlongan |
| author_sort | Nadia Sadanandan |
| collection | DOAJ |
| description | Stroke is a life-threatening condition that is characterized by secondary cell death processes that occur after the initial disruption of blood flow to the brain. The inability of endogenous repair mechanisms to sufficiently support functional recovery in stroke patients and the inadequate treatment options available are cause for concern. The pathology behind oxidative stress in stroke is of particular interest due to its detrimental effects on the brain. The oxidative stress caused by ischemic stroke overwhelms the neutralization capacity of the body’s endogenous antioxidant system, which leads to an overproduction of reactive oxygen species (ROS) and reactive nitrogen species (RNS) and eventually results in cell death. The overproduction of ROS compromises the functional and structural integrity of brain tissue. Therefore, it is essential to investigate the mechanisms involved in oxidative stress to help obtain adequate treatment options for stroke. Here, we focus on the latest preclinical research that details the mechanisms behind secondary cell death processes that cause many central nervous system (CNS) disorders, as well as research that relates to how the neuroprotective molecular mechanisms of pituitary adenylate cyclase-activating polypeptides (PACAPs) could make these molecules an ideal candidate for the treatment of stroke. |
| first_indexed | 2024-03-09T00:29:59Z |
| format | Article |
| id | doaj.art-e69d2c49853f402eb804536090fc2c05 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T00:29:59Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-e69d2c49853f402eb804536090fc2c052023-12-11T18:38:29ZengMDPI AGAntioxidants2076-39212021-02-0110335410.3390/antiox10030354Pituitary Adenylate Cyclase-Activating Polypeptide: A Potent Therapeutic Agent in Oxidative StressNadia Sadanandan0Blaise Cozene1You Jeong Park2Jeffrey Farooq3Chase Kingsbury4Zhen-Jie Wang5Alexa Moscatello6Madeline Saft7Justin Cho8Bella Gonzales-Portillo9Cesar V. Borlongan10Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL 33612, USADepartment of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL 33612, USADepartment of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL 33612, USADepartment of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL 33612, USADepartment of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL 33612, USADepartment of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL 33612, USADepartment of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL 33612, USADepartment of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL 33612, USADepartment of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL 33612, USADepartment of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL 33612, USADepartment of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL 33612, USAStroke is a life-threatening condition that is characterized by secondary cell death processes that occur after the initial disruption of blood flow to the brain. The inability of endogenous repair mechanisms to sufficiently support functional recovery in stroke patients and the inadequate treatment options available are cause for concern. The pathology behind oxidative stress in stroke is of particular interest due to its detrimental effects on the brain. The oxidative stress caused by ischemic stroke overwhelms the neutralization capacity of the body’s endogenous antioxidant system, which leads to an overproduction of reactive oxygen species (ROS) and reactive nitrogen species (RNS) and eventually results in cell death. The overproduction of ROS compromises the functional and structural integrity of brain tissue. Therefore, it is essential to investigate the mechanisms involved in oxidative stress to help obtain adequate treatment options for stroke. Here, we focus on the latest preclinical research that details the mechanisms behind secondary cell death processes that cause many central nervous system (CNS) disorders, as well as research that relates to how the neuroprotective molecular mechanisms of pituitary adenylate cyclase-activating polypeptides (PACAPs) could make these molecules an ideal candidate for the treatment of stroke.https://www.mdpi.com/2076-3921/10/3/354pituitary adenylate cyclase-activating polypeptidesantioxidantoxidative stressneurodegenerationreactive oxygen speciescell signaling |
| spellingShingle | Nadia Sadanandan Blaise Cozene You Jeong Park Jeffrey Farooq Chase Kingsbury Zhen-Jie Wang Alexa Moscatello Madeline Saft Justin Cho Bella Gonzales-Portillo Cesar V. Borlongan Pituitary Adenylate Cyclase-Activating Polypeptide: A Potent Therapeutic Agent in Oxidative Stress Antioxidants pituitary adenylate cyclase-activating polypeptides antioxidant oxidative stress neurodegeneration reactive oxygen species cell signaling |
| title | Pituitary Adenylate Cyclase-Activating Polypeptide: A Potent Therapeutic Agent in Oxidative Stress |
| title_full | Pituitary Adenylate Cyclase-Activating Polypeptide: A Potent Therapeutic Agent in Oxidative Stress |
| title_fullStr | Pituitary Adenylate Cyclase-Activating Polypeptide: A Potent Therapeutic Agent in Oxidative Stress |
| title_full_unstemmed | Pituitary Adenylate Cyclase-Activating Polypeptide: A Potent Therapeutic Agent in Oxidative Stress |
| title_short | Pituitary Adenylate Cyclase-Activating Polypeptide: A Potent Therapeutic Agent in Oxidative Stress |
| title_sort | pituitary adenylate cyclase activating polypeptide a potent therapeutic agent in oxidative stress |
| topic | pituitary adenylate cyclase-activating polypeptides antioxidant oxidative stress neurodegeneration reactive oxygen species cell signaling |
| url | https://www.mdpi.com/2076-3921/10/3/354 |
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