Protein tyrosine phosphatase controls breast cancer invasion through the expression of matrix metalloproteinase-9
The expression of matrix metalloproteinases (MMPs) produced bycancer cells has been associated with the high potential ofmetastasis in several human carcinomas, including breast cancer.Several pieces of evidence demonstrate that protein tyrosinephosphatases (PTP) have functions that promote cell mig...
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| Format: | Article |
| Language: | English |
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Korean Society for Biochemistry and Molecular Biology
2013-11-01
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| Series: | BMB Reports |
| Subjects: | |
| Online Access: | http://bmbreports.org/jbmb/pdf.php?data=MTMxMTI3MThAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0Ni0xMSU1RDEzMTEyNzE3NTRfJTI4NTMzLTUzOCUyOUJNQl8xMy0wNTMucGRm |
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| author | Bo-Mi Hwang Hee Suk Chae Young-Ju Jeong Young-Rae Lee Eun-Mi Noh Hyun Zo Youn Sung Hoo Jung Hong-Nu Yu Eun Yong Chung Jong-Suk Kim |
| author_facet | Bo-Mi Hwang Hee Suk Chae Young-Ju Jeong Young-Rae Lee Eun-Mi Noh Hyun Zo Youn Sung Hoo Jung Hong-Nu Yu Eun Yong Chung Jong-Suk Kim |
| author_sort | Bo-Mi Hwang |
| collection | DOAJ |
| description | The expression of matrix metalloproteinases (MMPs) produced bycancer cells has been associated with the high potential ofmetastasis in several human carcinomas, including breast cancer.Several pieces of evidence demonstrate that protein tyrosinephosphatases (PTP) have functions that promote cell migrationand metastasis in breast cancer. We analyzed whether PTPinhibitor might control breast cancer invasion through MMPexpression. Herein, we investigate the effect of 4-hydroxy-3,3-dimethyl-2H benzo[g]indole-2,5(3H)-dione (BVT948), anovel PTP inhibitor, on 12-O-tetradecanoyl phorbol-13-acetate(TPA)-induced MMP-9 expression and cell invasion in MCF-7cells. The expression of MMP-9 and cell invasion increased afterTPA treatment, whereas TPA-induced MMP-9 expression and cellinvasion were decreased by BVT948 pretreatment. Also, BVT948suppressed NF-κB activation in TPA-treated MCF-7 cells.However, BVT948 didn’t block TPA-induced AP-1 activation inMCF-7 cells. Our results suggest that the PTP inhibitor blocksbreast cancer invasion via suppression of the expression ofMMP-9. [BMB Reports 2013; 46(11): 533-538] |
| first_indexed | 2024-04-13T22:41:23Z |
| format | Article |
| id | doaj.art-e69d4e63bce2461dbb9275983166c626 |
| institution | Directory Open Access Journal |
| issn | 1976-6696 1976-670X |
| language | English |
| last_indexed | 2024-04-13T22:41:23Z |
| publishDate | 2013-11-01 |
| publisher | Korean Society for Biochemistry and Molecular Biology |
| record_format | Article |
| series | BMB Reports |
| spelling | doaj.art-e69d4e63bce2461dbb9275983166c6262022-12-22T02:26:36ZengKorean Society for Biochemistry and Molecular BiologyBMB Reports1976-66961976-670X2013-11-014611533538http://dx.doi.org/10.5483/BMBRep.2013.46.11.053Protein tyrosine phosphatase controls breast cancer invasion through the expression of matrix metalloproteinase-9Bo-Mi HwangHee Suk ChaeYoung-Ju JeongYoung-Rae LeeEun-Mi NohHyun Zo YounSung Hoo JungHong-Nu YuEun Yong ChungJong-Suk KimThe expression of matrix metalloproteinases (MMPs) produced bycancer cells has been associated with the high potential ofmetastasis in several human carcinomas, including breast cancer.Several pieces of evidence demonstrate that protein tyrosinephosphatases (PTP) have functions that promote cell migrationand metastasis in breast cancer. We analyzed whether PTPinhibitor might control breast cancer invasion through MMPexpression. Herein, we investigate the effect of 4-hydroxy-3,3-dimethyl-2H benzo[g]indole-2,5(3H)-dione (BVT948), anovel PTP inhibitor, on 12-O-tetradecanoyl phorbol-13-acetate(TPA)-induced MMP-9 expression and cell invasion in MCF-7cells. The expression of MMP-9 and cell invasion increased afterTPA treatment, whereas TPA-induced MMP-9 expression and cellinvasion were decreased by BVT948 pretreatment. Also, BVT948suppressed NF-κB activation in TPA-treated MCF-7 cells.However, BVT948 didn’t block TPA-induced AP-1 activation inMCF-7 cells. Our results suggest that the PTP inhibitor blocksbreast cancer invasion via suppression of the expression ofMMP-9. [BMB Reports 2013; 46(11): 533-538]http://bmbreports.org/jbmb/pdf.php?data=MTMxMTI3MThAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0Ni0xMSU1RDEzMTEyNzE3NTRfJTI4NTMzLTUzOCUyOUJNQl8xMy0wNTMucGRmMCF-7MetastasisMMPNF-κBPTP |
| spellingShingle | Bo-Mi Hwang Hee Suk Chae Young-Ju Jeong Young-Rae Lee Eun-Mi Noh Hyun Zo Youn Sung Hoo Jung Hong-Nu Yu Eun Yong Chung Jong-Suk Kim Protein tyrosine phosphatase controls breast cancer invasion through the expression of matrix metalloproteinase-9 BMB Reports MCF-7 Metastasis MMP NF-κB PTP |
| title | Protein tyrosine phosphatase controls breast cancer invasion through the expression of matrix metalloproteinase-9 |
| title_full | Protein tyrosine phosphatase controls breast cancer invasion through the expression of matrix metalloproteinase-9 |
| title_fullStr | Protein tyrosine phosphatase controls breast cancer invasion through the expression of matrix metalloproteinase-9 |
| title_full_unstemmed | Protein tyrosine phosphatase controls breast cancer invasion through the expression of matrix metalloproteinase-9 |
| title_short | Protein tyrosine phosphatase controls breast cancer invasion through the expression of matrix metalloproteinase-9 |
| title_sort | protein tyrosine phosphatase controls breast cancer invasion through the expression of matrix metalloproteinase 9 |
| topic | MCF-7 Metastasis MMP NF-κB PTP |
| url | http://bmbreports.org/jbmb/pdf.php?data=MTMxMTI3MThAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0Ni0xMSU1RDEzMTEyNzE3NTRfJTI4NTMzLTUzOCUyOUJNQl8xMy0wNTMucGRm |
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