Status of PD-1 and PD-L1 expression in invasive urothelial carcinoma of the bladder with mismatch repair protein deficiency
It has been reported that mismatch repair deficient (d-MMR) tumors show sensitivity to immune checkpoint inhibitors. We aimed to evaluate the correlation of d-MMR and PD-1/PD-L1 expression in invasive urothelial carcinoma of the bladder. Tissue microarray (TMA) tissues were stained PD-1/PD-L1 and MM...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2023-10-01
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| Series: | Polish Journal of Pathology |
| Subjects: | |
| Online Access: | https://www.termedia.pl/Status-of-PD-1-and-PD-L1-expression-in-invasive-urothelial-carcinoma-of-the-bladder-with-mismatch-repair-protein-deficiency,55,51678,1,1.html |
| _version_ | 1797450131384041472 |
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| author | Nuran Sungu Merve M. Kıran |
| author_facet | Nuran Sungu Merve M. Kıran |
| author_sort | Nuran Sungu |
| collection | DOAJ |
| description | It has been reported that mismatch repair deficient (d-MMR) tumors show sensitivity to immune checkpoint inhibitors. We aimed to evaluate the correlation of d-MMR and PD-1/PD-L1 expression in invasive urothelial carcinoma of the bladder. Tissue microarray (TMA) tissues were stained PD-1/PD-L1 and MMR proteins. The expression ratio of these markers has been compared with histopathologic parameters. d-MMR tumors were more superficial muscle invasive (p = 0.012). When the d-MMR, and PD-1/PD-L1 expression ratios were examined, a significant correlation was obtained between the d-MMR and PD-L1 expression ratio of > 5% in both the tumor and immune cells (p = 0.02 and p = 0.004, respectively). The expression ratio was higher in the patients without MMR loss. PD-1 and PD-L1expression in those with MSH6 loss was one or none. When PD1/PDL1 expression was compared with histopathological parameters, a significant relationship was observed between tumor grade and depth of muscle invasion. PD-L1 expression was not observed in the superficial muscle invasive tumors. This study was shown the status of d-MMR and PD-1/PD-L1 in invasive urothelial cancers and their correlation with prognostic markers. PD-1/PD-L1 expression may contribute to the progression and poor prognosis of bladder cancer. However, further studies are required to research the clinical utility. |
| first_indexed | 2024-03-09T14:35:09Z |
| format | Article |
| id | doaj.art-e69e408ff63640558aa045757ee1dc08 |
| institution | Directory Open Access Journal |
| issn | 1233-9687 2084-9869 |
| language | English |
| last_indexed | 2024-03-09T14:35:09Z |
| publishDate | 2023-10-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Polish Journal of Pathology |
| spelling | doaj.art-e69e408ff63640558aa045757ee1dc082023-11-27T12:45:32ZengTermedia Publishing HousePolish Journal of Pathology1233-96872084-98692023-10-0174316117010.5114/pjp.2023.13222151678Status of PD-1 and PD-L1 expression in invasive urothelial carcinoma of the bladder with mismatch repair protein deficiencyNuran SunguMerve M. KıranIt has been reported that mismatch repair deficient (d-MMR) tumors show sensitivity to immune checkpoint inhibitors. We aimed to evaluate the correlation of d-MMR and PD-1/PD-L1 expression in invasive urothelial carcinoma of the bladder. Tissue microarray (TMA) tissues were stained PD-1/PD-L1 and MMR proteins. The expression ratio of these markers has been compared with histopathologic parameters. d-MMR tumors were more superficial muscle invasive (p = 0.012). When the d-MMR, and PD-1/PD-L1 expression ratios were examined, a significant correlation was obtained between the d-MMR and PD-L1 expression ratio of > 5% in both the tumor and immune cells (p = 0.02 and p = 0.004, respectively). The expression ratio was higher in the patients without MMR loss. PD-1 and PD-L1expression in those with MSH6 loss was one or none. When PD1/PDL1 expression was compared with histopathological parameters, a significant relationship was observed between tumor grade and depth of muscle invasion. PD-L1 expression was not observed in the superficial muscle invasive tumors. This study was shown the status of d-MMR and PD-1/PD-L1 in invasive urothelial cancers and their correlation with prognostic markers. PD-1/PD-L1 expression may contribute to the progression and poor prognosis of bladder cancer. However, further studies are required to research the clinical utility.https://www.termedia.pl/Status-of-PD-1-and-PD-L1-expression-in-invasive-urothelial-carcinoma-of-the-bladder-with-mismatch-repair-protein-deficiency,55,51678,1,1.htmlbladder urothelial cancer pd-1 pd-l1 msi. |
| spellingShingle | Nuran Sungu Merve M. Kıran Status of PD-1 and PD-L1 expression in invasive urothelial carcinoma of the bladder with mismatch repair protein deficiency Polish Journal of Pathology bladder urothelial cancer pd-1 pd-l1 msi. |
| title | Status of PD-1 and PD-L1 expression in invasive urothelial carcinoma of the bladder with mismatch repair protein deficiency |
| title_full | Status of PD-1 and PD-L1 expression in invasive urothelial carcinoma of the bladder with mismatch repair protein deficiency |
| title_fullStr | Status of PD-1 and PD-L1 expression in invasive urothelial carcinoma of the bladder with mismatch repair protein deficiency |
| title_full_unstemmed | Status of PD-1 and PD-L1 expression in invasive urothelial carcinoma of the bladder with mismatch repair protein deficiency |
| title_short | Status of PD-1 and PD-L1 expression in invasive urothelial carcinoma of the bladder with mismatch repair protein deficiency |
| title_sort | status of pd 1 and pd l1 expression in invasive urothelial carcinoma of the bladder with mismatch repair protein deficiency |
| topic | bladder urothelial cancer pd-1 pd-l1 msi. |
| url | https://www.termedia.pl/Status-of-PD-1-and-PD-L1-expression-in-invasive-urothelial-carcinoma-of-the-bladder-with-mismatch-repair-protein-deficiency,55,51678,1,1.html |
| work_keys_str_mv | AT nuransungu statusofpd1andpdl1expressionininvasiveurothelialcarcinomaofthebladderwithmismatchrepairproteindeficiency AT mervemkıran statusofpd1andpdl1expressionininvasiveurothelialcarcinomaofthebladderwithmismatchrepairproteindeficiency |