EVOLUTION STAGES OF LOW RENIN HYPERTENSION
Aim. To find out similarities and differences between various evolutionary stages of low rennin hypertension (LRHT), and to develop its diagnostic criteria.Material and methods. Patients (n=190) with LRHT and the high cardiovascular risk were included into the study. All patients received ACE inhibi...
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| Format: | Article |
| Language: | English |
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Столичная издательская компания
2016-01-01
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| Series: | Рациональная фармакотерапия в кардиологии |
| Subjects: | |
| Online Access: | https://www.rpcardio.online/jour/article/view/772 |
| _version_ | 1797232332812320768 |
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| author | S. V. Akhadov G. R. Ruzbanova G. S. Molchanovа |
| author_facet | S. V. Akhadov G. R. Ruzbanova G. S. Molchanovа |
| author_sort | S. V. Akhadov |
| collection | DOAJ |
| description | Aim. To find out similarities and differences between various evolutionary stages of low rennin hypertension (LRHT), and to develop its diagnostic criteria.Material and methods. Patients (n=190) with LRHT and the high cardiovascular risk were included into the study. All patients received ACE inhibitor, enalapril 10 mg twice a day, during 4 weeks. Before and after enalapril treatment plasma renin activity (PRA) and plasma aldosterone level (PAL) were determined by radioimmunoassay method in active patients. 24-hour urinary excretion of epinephrine (UEE) and norepinephrine (UENE) was also determined by laser flowmetry.Results. Three forms of LRHT were defined among all patients: 1) patients (n=144) with essential LRHT had stimulated renin, eu- or hyperaldosteronism without adrenal hyperplasia; 2) patients (n=14) with transient LRHT had nonstimulated renin, eualdosteronism, presence or absence of adrenal hyperplasia; 3) patients (n=32) with the primary idiopathic hyperaldosteronism had nonstimulated renin, hyperaldosteronism and adrenal hyperplasia.Conclusion. Three stages of LRHT evolution are found out. They have similar pathogenesis and different expression of morphofunctional changes in the juxtaglomerular complex and in the adrenal cortex as well as different respond to enalapril test (20 mg/daily). |
| first_indexed | 2024-03-08T14:04:29Z |
| format | Article |
| id | doaj.art-e6a1ed41a281416894d802b7ffedec5b |
| institution | Directory Open Access Journal |
| issn | 1819-6446 2225-3653 |
| language | English |
| last_indexed | 2024-04-24T15:58:36Z |
| publishDate | 2016-01-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj.art-e6a1ed41a281416894d802b7ffedec5b2024-04-01T07:43:28ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532016-01-0161687210.20996/1819-6446-2010-6-1-68-72771EVOLUTION STAGES OF LOW RENIN HYPERTENSIONS. V. Akhadov0G. R. Ruzbanova1G. S. Molchanovа2City out-patient clinic N81City out-patient clinic N81Moscow Regional Clinical Research Institute named after M.F.VladimirskyAim. To find out similarities and differences between various evolutionary stages of low rennin hypertension (LRHT), and to develop its diagnostic criteria.Material and methods. Patients (n=190) with LRHT and the high cardiovascular risk were included into the study. All patients received ACE inhibitor, enalapril 10 mg twice a day, during 4 weeks. Before and after enalapril treatment plasma renin activity (PRA) and plasma aldosterone level (PAL) were determined by radioimmunoassay method in active patients. 24-hour urinary excretion of epinephrine (UEE) and norepinephrine (UENE) was also determined by laser flowmetry.Results. Three forms of LRHT were defined among all patients: 1) patients (n=144) with essential LRHT had stimulated renin, eu- or hyperaldosteronism without adrenal hyperplasia; 2) patients (n=14) with transient LRHT had nonstimulated renin, eualdosteronism, presence or absence of adrenal hyperplasia; 3) patients (n=32) with the primary idiopathic hyperaldosteronism had nonstimulated renin, hyperaldosteronism and adrenal hyperplasia.Conclusion. Three stages of LRHT evolution are found out. They have similar pathogenesis and different expression of morphofunctional changes in the juxtaglomerular complex and in the adrenal cortex as well as different respond to enalapril test (20 mg/daily).https://www.rpcardio.online/jour/article/view/772reninaldosteroneadrenal hyperplasiaenalapril |
| spellingShingle | S. V. Akhadov G. R. Ruzbanova G. S. Molchanovа EVOLUTION STAGES OF LOW RENIN HYPERTENSION Рациональная фармакотерапия в кардиологии renin aldosterone adrenal hyperplasia enalapril |
| title | EVOLUTION STAGES OF LOW RENIN HYPERTENSION |
| title_full | EVOLUTION STAGES OF LOW RENIN HYPERTENSION |
| title_fullStr | EVOLUTION STAGES OF LOW RENIN HYPERTENSION |
| title_full_unstemmed | EVOLUTION STAGES OF LOW RENIN HYPERTENSION |
| title_short | EVOLUTION STAGES OF LOW RENIN HYPERTENSION |
| title_sort | evolution stages of low renin hypertension |
| topic | renin aldosterone adrenal hyperplasia enalapril |
| url | https://www.rpcardio.online/jour/article/view/772 |
| work_keys_str_mv | AT svakhadov evolutionstagesoflowreninhypertension AT grruzbanova evolutionstagesoflowreninhypertension AT gsmolchanova evolutionstagesoflowreninhypertension |