IgG4-related disease of duodenal obstruction due to multiple ulcers in a 12-year-old girl
Abstract Background Immunoglobulin G4-related disease (IgG4-RD) is a systemic inflammatory disease and affected individuals typically present with an increased infiltration of IgG4-positive plasma cells in the pancreas, hepatobiliary tract, and liver but rarely in the gastrointestinal tract. Case pr...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-07-01
|
| Series: | BMC Pediatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12887-023-04190-z |
| _version_ | 1797769335090970624 |
|---|---|
| author | Daiki Kato Hiroo Uchida Akinari Hinoki Wataru Sumida Chiyoe Shirota Satoshi Makita Masamune Okamoto Aitaro Takimoto Shunya Takada Yoichi Nakagawa |
| author_facet | Daiki Kato Hiroo Uchida Akinari Hinoki Wataru Sumida Chiyoe Shirota Satoshi Makita Masamune Okamoto Aitaro Takimoto Shunya Takada Yoichi Nakagawa |
| author_sort | Daiki Kato |
| collection | DOAJ |
| description | Abstract Background Immunoglobulin G4-related disease (IgG4-RD) is a systemic inflammatory disease and affected individuals typically present with an increased infiltration of IgG4-positive plasma cells in the pancreas, hepatobiliary tract, and liver but rarely in the gastrointestinal tract. Case presentation A 12-year-old girl presented with vomiting and poor weight gain. Gastroscopy revealed duodenal stenosis and ulceration. Computed tomography revealed edematous duodenal wall thickening and air-fluid levels on the right side of the duodenum, which suggested duodenal perforation or penetration. She underwent pancreaticoduodenectomy, and IgG4-RD was diagnosed via histopathology. Conclusions This is the first pediatric case of isolated duodenal IgG4-RD resulting in duodenal obstruction after multiple ulcers. Gastrointestinal IgG4-RD should be among the differential diagnoses of unexplained gastrointestinal obstruction or ulceration even in children. |
| first_indexed | 2024-03-12T21:07:31Z |
| format | Article |
| id | doaj.art-e6a4c7787bc948cca7a8bb72faec352f |
| institution | Directory Open Access Journal |
| issn | 1471-2431 |
| language | English |
| last_indexed | 2024-03-12T21:07:31Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pediatrics |
| spelling | doaj.art-e6a4c7787bc948cca7a8bb72faec352f2023-07-30T11:24:54ZengBMCBMC Pediatrics1471-24312023-07-012311410.1186/s12887-023-04190-zIgG4-related disease of duodenal obstruction due to multiple ulcers in a 12-year-old girlDaiki Kato0Hiroo Uchida1Akinari Hinoki2Wataru Sumida3Chiyoe Shirota4Satoshi Makita5Masamune Okamoto6Aitaro Takimoto7Shunya Takada8Yoichi Nakagawa9Department of Pediatric Surgery, Nagoya University Graduate School of MedicineDepartment of Pediatric Surgery, Nagoya University Graduate School of MedicineDepartment of Rare/Intractable Cancer Analysis Research, Nagoya University Graduate School of MedicineDepartment of Pediatric Surgery, Nagoya University Graduate School of MedicineDepartment of Pediatric Surgery, Nagoya University Graduate School of MedicineDepartment of Pediatric Surgery, Nagoya University Graduate School of MedicineDepartment of Pediatric Surgery, Nagoya University Graduate School of MedicineDepartment of Pediatric Surgery, Nagoya University Graduate School of MedicineDepartment of Pediatric Surgery, Nagoya University Graduate School of MedicineDepartment of Pediatric Surgery, Nagoya University Graduate School of MedicineAbstract Background Immunoglobulin G4-related disease (IgG4-RD) is a systemic inflammatory disease and affected individuals typically present with an increased infiltration of IgG4-positive plasma cells in the pancreas, hepatobiliary tract, and liver but rarely in the gastrointestinal tract. Case presentation A 12-year-old girl presented with vomiting and poor weight gain. Gastroscopy revealed duodenal stenosis and ulceration. Computed tomography revealed edematous duodenal wall thickening and air-fluid levels on the right side of the duodenum, which suggested duodenal perforation or penetration. She underwent pancreaticoduodenectomy, and IgG4-RD was diagnosed via histopathology. Conclusions This is the first pediatric case of isolated duodenal IgG4-RD resulting in duodenal obstruction after multiple ulcers. Gastrointestinal IgG4-RD should be among the differential diagnoses of unexplained gastrointestinal obstruction or ulceration even in children.https://doi.org/10.1186/s12887-023-04190-zIgG4-related diseaseGastrointestinal ulcerationGastric outlet obstruction |
| spellingShingle | Daiki Kato Hiroo Uchida Akinari Hinoki Wataru Sumida Chiyoe Shirota Satoshi Makita Masamune Okamoto Aitaro Takimoto Shunya Takada Yoichi Nakagawa IgG4-related disease of duodenal obstruction due to multiple ulcers in a 12-year-old girl BMC Pediatrics IgG4-related disease Gastrointestinal ulceration Gastric outlet obstruction |
| title | IgG4-related disease of duodenal obstruction due to multiple ulcers in a 12-year-old girl |
| title_full | IgG4-related disease of duodenal obstruction due to multiple ulcers in a 12-year-old girl |
| title_fullStr | IgG4-related disease of duodenal obstruction due to multiple ulcers in a 12-year-old girl |
| title_full_unstemmed | IgG4-related disease of duodenal obstruction due to multiple ulcers in a 12-year-old girl |
| title_short | IgG4-related disease of duodenal obstruction due to multiple ulcers in a 12-year-old girl |
| title_sort | igg4 related disease of duodenal obstruction due to multiple ulcers in a 12 year old girl |
| topic | IgG4-related disease Gastrointestinal ulceration Gastric outlet obstruction |
| url | https://doi.org/10.1186/s12887-023-04190-z |
| work_keys_str_mv | AT daikikato igg4relateddiseaseofduodenalobstructionduetomultipleulcersina12yearoldgirl AT hiroouchida igg4relateddiseaseofduodenalobstructionduetomultipleulcersina12yearoldgirl AT akinarihinoki igg4relateddiseaseofduodenalobstructionduetomultipleulcersina12yearoldgirl AT watarusumida igg4relateddiseaseofduodenalobstructionduetomultipleulcersina12yearoldgirl AT chiyoeshirota igg4relateddiseaseofduodenalobstructionduetomultipleulcersina12yearoldgirl AT satoshimakita igg4relateddiseaseofduodenalobstructionduetomultipleulcersina12yearoldgirl AT masamuneokamoto igg4relateddiseaseofduodenalobstructionduetomultipleulcersina12yearoldgirl AT aitarotakimoto igg4relateddiseaseofduodenalobstructionduetomultipleulcersina12yearoldgirl AT shunyatakada igg4relateddiseaseofduodenalobstructionduetomultipleulcersina12yearoldgirl AT yoichinakagawa igg4relateddiseaseofduodenalobstructionduetomultipleulcersina12yearoldgirl |