Therapeutic Strategies and Chemoprevention of Atherosclerosis: What Do We Know and Where Do We Go?
Despite progress in understanding the pathogenesis of atherosclerosis, the development of effective therapeutic strategies is a challenging task that requires more research to attain its full potential. This review discusses current pharmacotherapy in atherosclerosis and explores the potential of so...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/14/4/722 |
| _version_ | 1797434324931313664 |
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| author | Ana Clara Aprotosoaie Alexandru-Dan Costache Irina-Iuliana Costache |
| author_facet | Ana Clara Aprotosoaie Alexandru-Dan Costache Irina-Iuliana Costache |
| author_sort | Ana Clara Aprotosoaie |
| collection | DOAJ |
| description | Despite progress in understanding the pathogenesis of atherosclerosis, the development of effective therapeutic strategies is a challenging task that requires more research to attain its full potential. This review discusses current pharmacotherapy in atherosclerosis and explores the potential of some important emerging therapies (antibody-based therapeutics, cytokine-targeting therapy, antisense oligonucleotides, photodynamic therapy and theranostics) in terms of clinical translation. A chemopreventive approach based on modern research of plant-derived products is also presented. Future perspectives on preventive and therapeutic management of atherosclerosis and the design of tailored treatments are outlined. |
| first_indexed | 2024-03-09T10:30:36Z |
| format | Article |
| id | doaj.art-e6a5022d5480414ca57302b2f08d3702 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T10:30:36Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-e6a5022d5480414ca57302b2f08d37022023-12-01T21:18:28ZengMDPI AGPharmaceutics1999-49232022-03-0114472210.3390/pharmaceutics14040722Therapeutic Strategies and Chemoprevention of Atherosclerosis: What Do We Know and Where Do We Go?Ana Clara Aprotosoaie0Alexandru-Dan Costache1Irina-Iuliana Costache2Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, RomaniaDepartment of Cardiovascular Rehabilitation, Clinical Rehabilitation Hospital, 700661 Iasi, RomaniaDepartment of Internal Medicine I, Faculty of Medicine, University of Medicine and Pharmacy “Grigore T. Popa”, 700115 Iasi, RomaniaDespite progress in understanding the pathogenesis of atherosclerosis, the development of effective therapeutic strategies is a challenging task that requires more research to attain its full potential. This review discusses current pharmacotherapy in atherosclerosis and explores the potential of some important emerging therapies (antibody-based therapeutics, cytokine-targeting therapy, antisense oligonucleotides, photodynamic therapy and theranostics) in terms of clinical translation. A chemopreventive approach based on modern research of plant-derived products is also presented. Future perspectives on preventive and therapeutic management of atherosclerosis and the design of tailored treatments are outlined.https://www.mdpi.com/1999-4923/14/4/722atherosclerosispharmacotherapyemergent therapeuticsnatural anti-atherosclerotic products |
| spellingShingle | Ana Clara Aprotosoaie Alexandru-Dan Costache Irina-Iuliana Costache Therapeutic Strategies and Chemoprevention of Atherosclerosis: What Do We Know and Where Do We Go? Pharmaceutics atherosclerosis pharmacotherapy emergent therapeutics natural anti-atherosclerotic products |
| title | Therapeutic Strategies and Chemoprevention of Atherosclerosis: What Do We Know and Where Do We Go? |
| title_full | Therapeutic Strategies and Chemoprevention of Atherosclerosis: What Do We Know and Where Do We Go? |
| title_fullStr | Therapeutic Strategies and Chemoprevention of Atherosclerosis: What Do We Know and Where Do We Go? |
| title_full_unstemmed | Therapeutic Strategies and Chemoprevention of Atherosclerosis: What Do We Know and Where Do We Go? |
| title_short | Therapeutic Strategies and Chemoprevention of Atherosclerosis: What Do We Know and Where Do We Go? |
| title_sort | therapeutic strategies and chemoprevention of atherosclerosis what do we know and where do we go |
| topic | atherosclerosis pharmacotherapy emergent therapeutics natural anti-atherosclerotic products |
| url | https://www.mdpi.com/1999-4923/14/4/722 |
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