Mutations in <it>ASXL1 </it>are associated with poor prognosis across the spectrum of malignant myeloid diseases

Mutations in <it>ASXL1 </it>are associated with poor prognosis across the spectrum of malignant myeloid diseases

<p>Abstract</p> <p>The <it>ASXL1 </it>gene is one of the most frequently mutated genes in malignant myeloid diseases. The ASXL1 protein belongs to protein complexes involved in the epigenetic regulation of gene expression. <it>ASXL1 </it>mutations are found...

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Bibliographic Details
Main Authors: Gelsi-Boyer Véronique, Brecqueville Mandy, Devillier Raynier, Murati Anne, Mozziconacci Marie-Joelle, Birnbaum Daniel
Format: Article
Language:English
Published: BMC 2012-03-01
Series:Journal of Hematology & Oncology
Subjects:
<it>ASXL1</it>
Gene mutations
Myeloid diseases
Online Access:http://www.jhoonline.org/content/5/1/12
Description
Summary:<p>Abstract</p> <p>The <it>ASXL1 </it>gene is one of the most frequently mutated genes in malignant myeloid diseases. The ASXL1 protein belongs to protein complexes involved in the epigenetic regulation of gene expression. <it>ASXL1 </it>mutations are found in myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML). They are generally associated with signs of aggressiveness and poor clinical outcome. Because of this, a systematic determination of <it>ASXL1 </it>mutational status in myeloid malignancies should help in prognosis assessment.</p>
ISSN:1756-8722

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