Mutations in <it>ASXL1 </it>are associated with poor prognosis across the spectrum of malignant myeloid diseases
<p>Abstract</p> <p>The <it>ASXL1 </it>gene is one of the most frequently mutated genes in malignant myeloid diseases. The ASXL1 protein belongs to protein complexes involved in the epigenetic regulation of gene expression. <it>ASXL1 </it>mutations are found...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-03-01
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| Series: | Journal of Hematology & Oncology |
| Subjects: | |
| Online Access: | http://www.jhoonline.org/content/5/1/12 |
| _version_ | 1819082519388094464 |
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| author | Gelsi-Boyer Véronique Brecqueville Mandy Devillier Raynier Murati Anne Mozziconacci Marie-Joelle Birnbaum Daniel |
| author_facet | Gelsi-Boyer Véronique Brecqueville Mandy Devillier Raynier Murati Anne Mozziconacci Marie-Joelle Birnbaum Daniel |
| author_sort | Gelsi-Boyer Véronique |
| collection | DOAJ |
| description | <p>Abstract</p> <p>The <it>ASXL1 </it>gene is one of the most frequently mutated genes in malignant myeloid diseases. The ASXL1 protein belongs to protein complexes involved in the epigenetic regulation of gene expression. <it>ASXL1 </it>mutations are found in myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML). They are generally associated with signs of aggressiveness and poor clinical outcome. Because of this, a systematic determination of <it>ASXL1 </it>mutational status in myeloid malignancies should help in prognosis assessment.</p> |
| first_indexed | 2024-12-21T20:17:58Z |
| format | Article |
| id | doaj.art-e6aa47128bce44b0bf2c7b6c8435c6de |
| institution | Directory Open Access Journal |
| issn | 1756-8722 |
| language | English |
| last_indexed | 2024-12-21T20:17:58Z |
| publishDate | 2012-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Hematology & Oncology |
| spelling | doaj.art-e6aa47128bce44b0bf2c7b6c8435c6de2022-12-21T18:51:33ZengBMCJournal of Hematology & Oncology1756-87222012-03-01511210.1186/1756-8722-5-12Mutations in <it>ASXL1 </it>are associated with poor prognosis across the spectrum of malignant myeloid diseasesGelsi-Boyer VéroniqueBrecqueville MandyDevillier RaynierMurati AnneMozziconacci Marie-JoelleBirnbaum Daniel<p>Abstract</p> <p>The <it>ASXL1 </it>gene is one of the most frequently mutated genes in malignant myeloid diseases. The ASXL1 protein belongs to protein complexes involved in the epigenetic regulation of gene expression. <it>ASXL1 </it>mutations are found in myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML). They are generally associated with signs of aggressiveness and poor clinical outcome. Because of this, a systematic determination of <it>ASXL1 </it>mutational status in myeloid malignancies should help in prognosis assessment.</p>http://www.jhoonline.org/content/5/1/12<it>ASXL1</it>Gene mutationsMyeloid diseases |
| spellingShingle | Gelsi-Boyer Véronique Brecqueville Mandy Devillier Raynier Murati Anne Mozziconacci Marie-Joelle Birnbaum Daniel Mutations in <it>ASXL1 </it>are associated with poor prognosis across the spectrum of malignant myeloid diseases Journal of Hematology & Oncology <it>ASXL1</it> Gene mutations Myeloid diseases |
| title | Mutations in <it>ASXL1 </it>are associated with poor prognosis across the spectrum of malignant myeloid diseases |
| title_full | Mutations in <it>ASXL1 </it>are associated with poor prognosis across the spectrum of malignant myeloid diseases |
| title_fullStr | Mutations in <it>ASXL1 </it>are associated with poor prognosis across the spectrum of malignant myeloid diseases |
| title_full_unstemmed | Mutations in <it>ASXL1 </it>are associated with poor prognosis across the spectrum of malignant myeloid diseases |
| title_short | Mutations in <it>ASXL1 </it>are associated with poor prognosis across the spectrum of malignant myeloid diseases |
| title_sort | mutations in it asxl1 it are associated with poor prognosis across the spectrum of malignant myeloid diseases |
| topic | <it>ASXL1</it> Gene mutations Myeloid diseases |
| url | http://www.jhoonline.org/content/5/1/12 |
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