Comparative Bioequivalence of Tablet and Capsule Formulations of Ulotaront and the Effect of Food on the Pharmacokinetics of the Tablet Form in Humans

Comparative Bioequivalence of Tablet and Capsule Formulations of Ulotaront and the Effect of Food on the Pharmacokinetics of the Tablet Form in Humans

Abstract Introduction Ulotaront (SEP-363856), a dual trace animeassociated receptor 1 (TAAR1) and 5-HT1A receptor agonist, is in phase 3 clinical development for the treatment of schizophrenia. This study evaluated the comparative bioequivalence (BE) between tablet and capsule formulations of ulotar...

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Bibliographic Details
Main Authors: Yu-Luan Chen, Hironobu Tsukada, Snezana Milanovic, Lei Shi, Yan Li, Yongcai Mao, Kenneth S. Koblan, Gerald R. Galluppi
Format: Article
Language:English
Published: Adis, Springer Healthcare 2023-03-01
Series:Neurology and Therapy
Subjects:
Ulotaront (SEP-363856)
Comparative bioequivalence
Food effect
N-Desmethyl metabolite
LC–MS/MS
Pharmacokinetics
Online Access:https://doi.org/10.1007/s40120-023-00459-8

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