Postprandial Glycaemia, Insulinemia, and Lipidemia after 12 Weeks’ Cheese Consumption: An Exploratory Randomized Controlled Human Sub-Study
Some populations are recommended to consume low-fat dairy, although the evidence behind replacing high-fat with low-fat dairy products is limited. This exploratory sub-study investigated the effect of cheese with different fat content on postprandial changes in type-2-diabetes risk markers. Followin...
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| Format: | Article |
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MDPI AG
2023-01-01
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| Online Access: | https://www.mdpi.com/2624-862X/4/1/4 |
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| author | Louise Kjølbæk Farinaz Raziani Tine Tholstrup Rosa Caroline Jullie Rudnicki Christian Ritz Arne Astrup Anne Raben |
| author_facet | Louise Kjølbæk Farinaz Raziani Tine Tholstrup Rosa Caroline Jullie Rudnicki Christian Ritz Arne Astrup Anne Raben |
| author_sort | Louise Kjølbæk |
| collection | DOAJ |
| description | Some populations are recommended to consume low-fat dairy, although the evidence behind replacing high-fat with low-fat dairy products is limited. This exploratory sub-study investigated the effect of cheese with different fat content on postprandial changes in type-2-diabetes risk markers. Following 12-week cheese or jam intake, a 4 h meal test was conducted with 37 participants. Test meals included bread and either: 80 g regular-fat cheese (REG), 80 g reduced-fat cheese (RED) or 25 g jam (CHO). Postprandial blood was drawn and appetite sensations registered. Time-meal interactions were not observed for glucose and insulin, but for triglycerides (TG) and free fatty acids (FFA). Pairwise comparisons showed 0.17 ± 0.07 mmol/L (<i>p</i> = 0.044) and 0.25 ± 0.07 mmol/L (<i>p</i> = 0.002) higher TG at 180 and 240 min, respectively, and 94 ± 37 mmol/L (<i>p</i> = 0.029) higher FFA at 180 min for REG compared with RED. Compared with CHO, intake of both cheese meals reduced insulin and glucose (main effects of meal, both <i>p</i> ≤ 0.011) and increased FFA and TG at certain time points. In conclusion, intake of cheese with a regular, compared with reduced, fat content did not affect glucose, insulin and appetite, but increased TG and FFA. |
| first_indexed | 2024-03-11T06:42:18Z |
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| institution | Directory Open Access Journal |
| issn | 2624-862X |
| language | English |
| last_indexed | 2024-03-11T06:42:18Z |
| publishDate | 2023-01-01 |
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| series | Dairy |
| spelling | doaj.art-e6aa6aa46b6b4060961b4439906b89c62023-11-17T10:31:42ZengMDPI AGDairy2624-862X2023-01-0141688210.3390/dairy4010004Postprandial Glycaemia, Insulinemia, and Lipidemia after 12 Weeks’ Cheese Consumption: An Exploratory Randomized Controlled Human Sub-StudyLouise Kjølbæk0Farinaz Raziani1Tine Tholstrup2Rosa Caroline Jullie Rudnicki3Christian Ritz4Arne Astrup5Anne Raben6Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg C, DenmarkY-mAbs Therapeutics, Agern Alle 11, 2970 Hørsholm, DenmarkDepartment of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg C, DenmarkCenter for Rheumatology and Spine Diseases, Copenhagen University Hospital Rigshospitalet, Juliane Maries vej 10, 2100 Copenhagen Ø, DenmarkNational Institute of Public Health, University of Southern Denmark, Studiestræde 6, 1455 Copenhagen K, DenmarkHealthy Weight Center, Novo Nordisk Foundation, Tuborg Havnevej 19, 2900 Hellerup, DenmarkDepartment of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg C, DenmarkSome populations are recommended to consume low-fat dairy, although the evidence behind replacing high-fat with low-fat dairy products is limited. This exploratory sub-study investigated the effect of cheese with different fat content on postprandial changes in type-2-diabetes risk markers. Following 12-week cheese or jam intake, a 4 h meal test was conducted with 37 participants. Test meals included bread and either: 80 g regular-fat cheese (REG), 80 g reduced-fat cheese (RED) or 25 g jam (CHO). Postprandial blood was drawn and appetite sensations registered. Time-meal interactions were not observed for glucose and insulin, but for triglycerides (TG) and free fatty acids (FFA). Pairwise comparisons showed 0.17 ± 0.07 mmol/L (<i>p</i> = 0.044) and 0.25 ± 0.07 mmol/L (<i>p</i> = 0.002) higher TG at 180 and 240 min, respectively, and 94 ± 37 mmol/L (<i>p</i> = 0.029) higher FFA at 180 min for REG compared with RED. Compared with CHO, intake of both cheese meals reduced insulin and glucose (main effects of meal, both <i>p</i> ≤ 0.011) and increased FFA and TG at certain time points. In conclusion, intake of cheese with a regular, compared with reduced, fat content did not affect glucose, insulin and appetite, but increased TG and FFA.https://www.mdpi.com/2624-862X/4/1/4postprandialacuteinsulinglucosetriglyceridesfree fatty acids |
| spellingShingle | Louise Kjølbæk Farinaz Raziani Tine Tholstrup Rosa Caroline Jullie Rudnicki Christian Ritz Arne Astrup Anne Raben Postprandial Glycaemia, Insulinemia, and Lipidemia after 12 Weeks’ Cheese Consumption: An Exploratory Randomized Controlled Human Sub-Study Dairy postprandial acute insulin glucose triglycerides free fatty acids |
| title | Postprandial Glycaemia, Insulinemia, and Lipidemia after 12 Weeks’ Cheese Consumption: An Exploratory Randomized Controlled Human Sub-Study |
| title_full | Postprandial Glycaemia, Insulinemia, and Lipidemia after 12 Weeks’ Cheese Consumption: An Exploratory Randomized Controlled Human Sub-Study |
| title_fullStr | Postprandial Glycaemia, Insulinemia, and Lipidemia after 12 Weeks’ Cheese Consumption: An Exploratory Randomized Controlled Human Sub-Study |
| title_full_unstemmed | Postprandial Glycaemia, Insulinemia, and Lipidemia after 12 Weeks’ Cheese Consumption: An Exploratory Randomized Controlled Human Sub-Study |
| title_short | Postprandial Glycaemia, Insulinemia, and Lipidemia after 12 Weeks’ Cheese Consumption: An Exploratory Randomized Controlled Human Sub-Study |
| title_sort | postprandial glycaemia insulinemia and lipidemia after 12 weeks cheese consumption an exploratory randomized controlled human sub study |
| topic | postprandial acute insulin glucose triglycerides free fatty acids |
| url | https://www.mdpi.com/2624-862X/4/1/4 |
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