Association between cystatin C and diabetic retinopathy among type 2 diabetic patients in China: a Meta-analysis
AIM: To explore the correlation between cystatin C (Cys-C) and diabetic retinopathy (DR) in those patients with type 2 diabetes mellitus (DM) in China. METHODS: Articles were collected from China National Knowledge Infrastructure (CNKI), Wanfang, VIP, PubMed, EMBASE, Cochrane Library, Clinical Trial...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2021-09-01
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| Series: | International Journal of Ophthalmology |
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| Online Access: | http://ies.ijo.cn/en_publish/2021/9/20210921.pdf |
| _version_ | 1819066394145193984 |
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| author | Nan Yang Yun-Fei Lu Xiao Yang Kui Jiang Ai-Min Sang Hui-Qun Wu |
| author_facet | Nan Yang Yun-Fei Lu Xiao Yang Kui Jiang Ai-Min Sang Hui-Qun Wu |
| author_sort | Nan Yang |
| collection | DOAJ |
| description | AIM: To explore the correlation between cystatin C (Cys-C) and diabetic retinopathy (DR) in those patients with type 2 diabetes mellitus (DM) in China. METHODS: Articles were collected from China National Knowledge Infrastructure (CNKI), Wanfang, VIP, PubMed, EMBASE, Cochrane Library, Clinical Trials.gov, and Google Scholar. Quality and risk of bias within included studies was assessed using the Newcastle-Ottawa scale (NOS). Heterogeneity was determined by using Cochran's Q-test and Higgins I2 statistics. Mean differences (MDs) and 95% confidence intervals (CIs) of Cys-C within the diabetes without retinopathy (DWR) and DR, DWR and non-proliferative diabetic retinopathy (NPDR), NPDR and proliferative diabetic retinopathy (PDR) were collected by using random-effects model because of high heterogeneity. Meta-analysis was conducted based on 23 articles of 2331 DR including NPDR and PDR patients and 2023 DWR patients through Review Manager 5.3. Subgroup analyses were also performed according to DM duration, body mass index (BMI), total cholesterol (TC), total triglycerides (TG), low-density lipoprotein C (LDL-C), and high-density lipoprotein C (HDL-C), sample origins and methods. Publication bias was assessed by the funnel plot. RESULTS: Cys-C level in DR patients was increased compared with that of DWR (total MD: 0.69, 95%CI: 0.41 to 0.97, Z=4.79, P<0.01). Besides, the synthesized results of the studies showed the similar findings in the DWR vs NPDR group (total MD: 0.29, 95%CI 0.20 to 0.39, Z=6.02, P<0.01) and the NPDR vs PDR group (total MD: 0.63, 95%CI 0.43 to 0.82, Z=6.33, P<0.01). Heterogeneity of most of the subgroup analyses was still obvious (I2?≥?50%, P?<?0.1). Forest plots of different subgroups indicated that there was a slight increase of Cys-C during the period between DWR and DR, DWR and NPDR, NPDR and PDR. Funnel plot showed that there was no significant publication bias. CONCLUSION: The elevated Cys-C is closely related with DR and probably plays a critical role in its progression. |
| first_indexed | 2024-12-21T16:01:39Z |
| format | Article |
| id | doaj.art-e6ac5633febd4a339bc2d4136abb3e33 |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-12-21T16:01:39Z |
| publishDate | 2021-09-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-e6ac5633febd4a339bc2d4136abb3e332022-12-21T18:57:59ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982021-09-011491430144010.18240/ijo.2021.09.2120210921Association between cystatin C and diabetic retinopathy among type 2 diabetic patients in China: a Meta-analysisNan Yang0Yun-Fei Lu1Xiao Yang2Kui Jiang3Ai-Min Sang4Hui-Qun Wu5Hui-Qun Wu. Department of Medical Informatics, Medical School of Nantong University, Nantong 226001, Jiangsu Province, China. wuhuiqun@ntu.edu.cnDepartment of Medical Informatics, Medical School of Nantong University, Nantong 226001, Jiangsu Province, ChinaDepartment of Medical Informatics, Medical School of Nantong University, Nantong 226001, Jiangsu Province, ChinaDepartment of Medical Informatics, Medical School of Nantong University, Nantong 226001, Jiangsu Province, ChinaDepartment of Ophthalmology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, ChinaDepartment of Medical Informatics, Medical School of Nantong University, Nantong 226001, Jiangsu Province, ChinaAIM: To explore the correlation between cystatin C (Cys-C) and diabetic retinopathy (DR) in those patients with type 2 diabetes mellitus (DM) in China. METHODS: Articles were collected from China National Knowledge Infrastructure (CNKI), Wanfang, VIP, PubMed, EMBASE, Cochrane Library, Clinical Trials.gov, and Google Scholar. Quality and risk of bias within included studies was assessed using the Newcastle-Ottawa scale (NOS). Heterogeneity was determined by using Cochran's Q-test and Higgins I2 statistics. Mean differences (MDs) and 95% confidence intervals (CIs) of Cys-C within the diabetes without retinopathy (DWR) and DR, DWR and non-proliferative diabetic retinopathy (NPDR), NPDR and proliferative diabetic retinopathy (PDR) were collected by using random-effects model because of high heterogeneity. Meta-analysis was conducted based on 23 articles of 2331 DR including NPDR and PDR patients and 2023 DWR patients through Review Manager 5.3. Subgroup analyses were also performed according to DM duration, body mass index (BMI), total cholesterol (TC), total triglycerides (TG), low-density lipoprotein C (LDL-C), and high-density lipoprotein C (HDL-C), sample origins and methods. Publication bias was assessed by the funnel plot. RESULTS: Cys-C level in DR patients was increased compared with that of DWR (total MD: 0.69, 95%CI: 0.41 to 0.97, Z=4.79, P<0.01). Besides, the synthesized results of the studies showed the similar findings in the DWR vs NPDR group (total MD: 0.29, 95%CI 0.20 to 0.39, Z=6.02, P<0.01) and the NPDR vs PDR group (total MD: 0.63, 95%CI 0.43 to 0.82, Z=6.33, P<0.01). Heterogeneity of most of the subgroup analyses was still obvious (I2?≥?50%, P?<?0.1). Forest plots of different subgroups indicated that there was a slight increase of Cys-C during the period between DWR and DR, DWR and NPDR, NPDR and PDR. Funnel plot showed that there was no significant publication bias. CONCLUSION: The elevated Cys-C is closely related with DR and probably plays a critical role in its progression.http://ies.ijo.cn/en_publish/2021/9/20210921.pdfdiabetic retinopathycystatin cmeta-analysis |
| spellingShingle | Nan Yang Yun-Fei Lu Xiao Yang Kui Jiang Ai-Min Sang Hui-Qun Wu Association between cystatin C and diabetic retinopathy among type 2 diabetic patients in China: a Meta-analysis International Journal of Ophthalmology diabetic retinopathy cystatin c meta-analysis |
| title | Association between cystatin C and diabetic retinopathy among type 2 diabetic patients in China: a Meta-analysis |
| title_full | Association between cystatin C and diabetic retinopathy among type 2 diabetic patients in China: a Meta-analysis |
| title_fullStr | Association between cystatin C and diabetic retinopathy among type 2 diabetic patients in China: a Meta-analysis |
| title_full_unstemmed | Association between cystatin C and diabetic retinopathy among type 2 diabetic patients in China: a Meta-analysis |
| title_short | Association between cystatin C and diabetic retinopathy among type 2 diabetic patients in China: a Meta-analysis |
| title_sort | association between cystatin c and diabetic retinopathy among type 2 diabetic patients in china a meta analysis |
| topic | diabetic retinopathy cystatin c meta-analysis |
| url | http://ies.ijo.cn/en_publish/2021/9/20210921.pdf |
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