THE BIOLOGICAL ACTIVITY OF SODIUM DICHLOROACETATE: CONCEPTS AND MECHANISMS (LITERATURE REVIEW)
Though the biological activity of sodium dichloroacetate in medicine has been researched for the last forty-five years, our literature review is considered to be the first one in the domestic scientific literature and must draw the researchers' attention to this range of problems. During the cl...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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Ministry of Healthcare of the Russian Federation. “Kuban State Medical University”
2016-12-01
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| Series: | Кубанский научный медицинский вестник |
| Subjects: | |
| Online Access: | https://ksma.elpub.ru/jour/article/view/647 |
| _version_ | 1826568864453885952 |
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| author | A. M. Manuilov K. A. Popov I. Y. Tsymbalyuk M. G. Litvinova F. U. Khubieva A. V. Shestopalov |
| author_facet | A. M. Manuilov K. A. Popov I. Y. Tsymbalyuk M. G. Litvinova F. U. Khubieva A. V. Shestopalov |
| author_sort | A. M. Manuilov |
| collection | DOAJ |
| description | Though the biological activity of sodium dichloroacetate in medicine has been researched for the last forty-five years, our literature review is considered to be the first one in the domestic scientific literature and must draw the researchers' attention to this range of problems. During the clinic-experimental studies the effectiveness of sodium dichloroacetate as the cytoprotector in a number of pathological processes involving the mitochondrial dysfunction was researched as well as its antitumoral activity. The mechanism of its effect was associated with the activation of the pyruvate dehydrogenase complex and as a result of it the energy metabolism. In normal cells in the hypoxia conditions this leads to the optimization of oxygen consumption and the prevention of sulphur acidulation. In atypical cells this causes the metabolism inversion including the intensification of free-radical processes, the activation of caspase enzyme cascade, the activity lowering of proproliferative and proangiogenic transcriptional factors. |
| first_indexed | 2024-03-07T21:49:56Z |
| format | Article |
| id | doaj.art-e6ae1429ea8d4547aaa9228d32ebc730 |
| institution | Directory Open Access Journal |
| issn | 1608-6228 2541-9544 |
| language | Russian |
| last_indexed | 2025-03-14T11:30:13Z |
| publishDate | 2016-12-01 |
| publisher | Ministry of Healthcare of the Russian Federation. “Kuban State Medical University” |
| record_format | Article |
| series | Кубанский научный медицинский вестник |
| spelling | doaj.art-e6ae1429ea8d4547aaa9228d32ebc7302025-03-02T10:05:29ZrusMinistry of Healthcare of the Russian Federation. “Kuban State Medical University”Кубанский научный медицинский вестник1608-62282541-95442016-12-016156163647THE BIOLOGICAL ACTIVITY OF SODIUM DICHLOROACETATE: CONCEPTS AND MECHANISMS (LITERATURE REVIEW)A. M. Manuilov0K. A. Popov1I. Y. Tsymbalyuk2M. G. Litvinova3F. U. Khubieva4A. V. Shestopalov5Kuban State Medical UniversityKuban State Medical UniversityKuban State Medical UniversityKuban State Medical UniversityKuban State Medical UniversityDmitry Rogachev Federal Research CenterThough the biological activity of sodium dichloroacetate in medicine has been researched for the last forty-five years, our literature review is considered to be the first one in the domestic scientific literature and must draw the researchers' attention to this range of problems. During the clinic-experimental studies the effectiveness of sodium dichloroacetate as the cytoprotector in a number of pathological processes involving the mitochondrial dysfunction was researched as well as its antitumoral activity. The mechanism of its effect was associated with the activation of the pyruvate dehydrogenase complex and as a result of it the energy metabolism. In normal cells in the hypoxia conditions this leads to the optimization of oxygen consumption and the prevention of sulphur acidulation. In atypical cells this causes the metabolism inversion including the intensification of free-radical processes, the activation of caspase enzyme cascade, the activity lowering of proproliferative and proangiogenic transcriptional factors.https://ksma.elpub.ru/jour/article/view/647дихлорацетат натриямитохондриальная дисфункцияпируватдегидрогеназаметаболическая цитопротекцияsodium dichloroacetatemitochondrial dysfunctionpyruvate dehydrogenasemetabolic cytoprotection |
| spellingShingle | A. M. Manuilov K. A. Popov I. Y. Tsymbalyuk M. G. Litvinova F. U. Khubieva A. V. Shestopalov THE BIOLOGICAL ACTIVITY OF SODIUM DICHLOROACETATE: CONCEPTS AND MECHANISMS (LITERATURE REVIEW) Кубанский научный медицинский вестник дихлорацетат натрия митохондриальная дисфункция пируватдегидрогеназа метаболическая цитопротекция sodium dichloroacetate mitochondrial dysfunction pyruvate dehydrogenase metabolic cytoprotection |
| title | THE BIOLOGICAL ACTIVITY OF SODIUM DICHLOROACETATE: CONCEPTS AND MECHANISMS (LITERATURE REVIEW) |
| title_full | THE BIOLOGICAL ACTIVITY OF SODIUM DICHLOROACETATE: CONCEPTS AND MECHANISMS (LITERATURE REVIEW) |
| title_fullStr | THE BIOLOGICAL ACTIVITY OF SODIUM DICHLOROACETATE: CONCEPTS AND MECHANISMS (LITERATURE REVIEW) |
| title_full_unstemmed | THE BIOLOGICAL ACTIVITY OF SODIUM DICHLOROACETATE: CONCEPTS AND MECHANISMS (LITERATURE REVIEW) |
| title_short | THE BIOLOGICAL ACTIVITY OF SODIUM DICHLOROACETATE: CONCEPTS AND MECHANISMS (LITERATURE REVIEW) |
| title_sort | biological activity of sodium dichloroacetate concepts and mechanisms literature review |
| topic | дихлорацетат натрия митохондриальная дисфункция пируватдегидрогеназа метаболическая цитопротекция sodium dichloroacetate mitochondrial dysfunction pyruvate dehydrogenase metabolic cytoprotection |
| url | https://ksma.elpub.ru/jour/article/view/647 |
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