Phage display screening of therapeutic peptide for cancer targeting and therapy
ABSTRACT Recently, phage display technology has been announced as the recipient of Nobel Prize in Chemistry 2018. Phage display technique allows high affinity target-binding peptides to be selected from a complex mixture pool of billions of displayed peptides on phage in a combinatorial library and...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Oxford University Press
2019-05-01
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| Series: | Protein & Cell |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1007/s13238-019-0639-7 |
| _version_ | 1797723080133443584 |
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| author | Phei Er Saw Er-Wei Song |
| author_facet | Phei Er Saw Er-Wei Song |
| author_sort | Phei Er Saw |
| collection | DOAJ |
| description | ABSTRACT Recently, phage display technology has been announced as the recipient of Nobel Prize in Chemistry 2018. Phage display technique allows high affinity target-binding peptides to be selected from a complex mixture pool of billions of displayed peptides on phage in a combinatorial library and could be further enriched through the biopanning process; proving to be a powerful technique in the screening of peptide with high affinity and selectivity. In this review, we will first discuss the modifications in phage display techniques used to isolate various cancer-specific ligands by in situ, in vitro, in vivo, and ex vivo screening methods. We will then discuss prominent examples of solid tumor targeting-peptides; namely peptide targeting tumor vasculature, tumor microenvironment (TME) and over-expressed receptors on cancer cells identified through phage display screening. We will also discuss the current challenges and future outlook for targeting peptide-based therapeutics in the clinics. |
| first_indexed | 2024-03-12T09:57:54Z |
| format | Article |
| id | doaj.art-e6aeee0b11ef47b982381de39ffc0f98 |
| institution | Directory Open Access Journal |
| issn | 1674-800X 1674-8018 |
| language | English |
| last_indexed | 2024-03-12T09:57:54Z |
| publishDate | 2019-05-01 |
| publisher | Oxford University Press |
| record_format | Article |
| series | Protein & Cell |
| spelling | doaj.art-e6aeee0b11ef47b982381de39ffc0f982023-09-02T12:05:01ZengOxford University PressProtein & Cell1674-800X1674-80182019-05-01101178780710.1007/s13238-019-0639-7Phage display screening of therapeutic peptide for cancer targeting and therapyPhei Er Saw0Er-Wei Song1Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityABSTRACT Recently, phage display technology has been announced as the recipient of Nobel Prize in Chemistry 2018. Phage display technique allows high affinity target-binding peptides to be selected from a complex mixture pool of billions of displayed peptides on phage in a combinatorial library and could be further enriched through the biopanning process; proving to be a powerful technique in the screening of peptide with high affinity and selectivity. In this review, we will first discuss the modifications in phage display techniques used to isolate various cancer-specific ligands by in situ, in vitro, in vivo, and ex vivo screening methods. We will then discuss prominent examples of solid tumor targeting-peptides; namely peptide targeting tumor vasculature, tumor microenvironment (TME) and over-expressed receptors on cancer cells identified through phage display screening. We will also discuss the current challenges and future outlook for targeting peptide-based therapeutics in the clinics.http://link.springer.com/article/10.1007/s13238-019-0639-7phage displaytumor targeting peptidetumor vasculaturetumor microenvironmenttumor stromal cellsover-expressed receptor |
| spellingShingle | Phei Er Saw Er-Wei Song Phage display screening of therapeutic peptide for cancer targeting and therapy Protein & Cell phage display tumor targeting peptide tumor vasculature tumor microenvironment tumor stromal cells over-expressed receptor |
| title | Phage display screening of therapeutic peptide for cancer targeting and therapy |
| title_full | Phage display screening of therapeutic peptide for cancer targeting and therapy |
| title_fullStr | Phage display screening of therapeutic peptide for cancer targeting and therapy |
| title_full_unstemmed | Phage display screening of therapeutic peptide for cancer targeting and therapy |
| title_short | Phage display screening of therapeutic peptide for cancer targeting and therapy |
| title_sort | phage display screening of therapeutic peptide for cancer targeting and therapy |
| topic | phage display tumor targeting peptide tumor vasculature tumor microenvironment tumor stromal cells over-expressed receptor |
| url | http://link.springer.com/article/10.1007/s13238-019-0639-7 |
| work_keys_str_mv | AT pheiersaw phagedisplayscreeningoftherapeuticpeptideforcancertargetingandtherapy AT erweisong phagedisplayscreeningoftherapeuticpeptideforcancertargetingandtherapy |