Escherichia coli resistance mechanism AcrAB-TolC efflux pump interactions with commonly used antibiotics: a molecular dynamics study

Abstract While antibiotic resistance poses a threat from both Gram-positive bacteria (GPB) and Gram-negative bacteria (GNB), GNB pose a more imminent public health hazard globally. GNB are a threat to growing antibiotic resistance because of the complex makeup of the membrane. The AcrAB-TolC efflux...

Descrición completa

Detalles Bibliográficos
Main Authors: Brooke L. Smith, Sandun Fernando, Maria D. King
Formato: Artigo
Idioma:English
Publicado: Nature Portfolio 2024-02-01
Series:Scientific Reports
Acceso en liña:https://doi.org/10.1038/s41598-024-52536-z