Race modifies default mode connectivity in Alzheimer’s disease
Abstract Background Older African Americans are more likely to develop Alzheimer’s disease (AD) than older Caucasians, and this difference cannot be readily explained by cerebrovascular and socioeconomic factors alone. We previously showed that mild cognitive impairment and AD dementia were associat...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-02-01
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| Series: | Translational Neurodegeneration |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40035-020-0186-4 |
| _version_ | 1818507839333728256 |
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| author | Maria B. Misiura J. Christina Howell Junjie Wu Deqiang Qiu Monica W. Parker Jessica A. Turner William T. Hu |
| author_facet | Maria B. Misiura J. Christina Howell Junjie Wu Deqiang Qiu Monica W. Parker Jessica A. Turner William T. Hu |
| author_sort | Maria B. Misiura |
| collection | DOAJ |
| description | Abstract Background Older African Americans are more likely to develop Alzheimer’s disease (AD) than older Caucasians, and this difference cannot be readily explained by cerebrovascular and socioeconomic factors alone. We previously showed that mild cognitive impairment and AD dementia were associated with attenuated increases in the cerebrospinal fluid (CSF) levels of total and phosphorylated tau in African Americans compared to Caucasians, even though there was no difference in beta-amyloid 1–42 level between the two races. Methods We extended our work by analyzing early functional magnetic resonance imaging (fMRI) biomarkers of the default mode network in older African Americans and Caucasians. We calculated connectivity between nodes of the regions belonging to the various default mode network subsystems and correlated these imaging biomarkers with non-imaging biomarkers implicated in AD (CSF amyloid, total tau, and cognitive performance). Results We found that race modifies the relationship between functional connectivity of default mode network subsystems and cognitive performance, tau, and amyloid levels. Conclusion These findings provide further support that race modifies the AD phenotypes downstream from cerebral amyloid deposition, and identifies key inter-subsystem connections for deep imaging and neuropathologic characterization. |
| first_indexed | 2024-12-10T22:23:36Z |
| format | Article |
| id | doaj.art-e6b2e07cd7e348d1b12e59e67e117e44 |
| institution | Directory Open Access Journal |
| issn | 2047-9158 |
| language | English |
| last_indexed | 2024-12-10T22:23:36Z |
| publishDate | 2020-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Translational Neurodegeneration |
| spelling | doaj.art-e6b2e07cd7e348d1b12e59e67e117e442022-12-22T01:31:14ZengBMCTranslational Neurodegeneration2047-91582020-02-019111510.1186/s40035-020-0186-4Race modifies default mode connectivity in Alzheimer’s diseaseMaria B. Misiura0J. Christina Howell1Junjie Wu2Deqiang Qiu3Monica W. Parker4Jessica A. Turner5William T. Hu6Department of Psychology, Georgia State UniversityDepartments of Neurology, Emory UniversityDepartments of Radiology, Emory UniversityDepartments of Radiology, Emory UniversityDepartments of Neurology, Emory UniversityDepartment of Psychology, Georgia State UniversityDepartments of Neurology, Emory UniversityAbstract Background Older African Americans are more likely to develop Alzheimer’s disease (AD) than older Caucasians, and this difference cannot be readily explained by cerebrovascular and socioeconomic factors alone. We previously showed that mild cognitive impairment and AD dementia were associated with attenuated increases in the cerebrospinal fluid (CSF) levels of total and phosphorylated tau in African Americans compared to Caucasians, even though there was no difference in beta-amyloid 1–42 level between the two races. Methods We extended our work by analyzing early functional magnetic resonance imaging (fMRI) biomarkers of the default mode network in older African Americans and Caucasians. We calculated connectivity between nodes of the regions belonging to the various default mode network subsystems and correlated these imaging biomarkers with non-imaging biomarkers implicated in AD (CSF amyloid, total tau, and cognitive performance). Results We found that race modifies the relationship between functional connectivity of default mode network subsystems and cognitive performance, tau, and amyloid levels. Conclusion These findings provide further support that race modifies the AD phenotypes downstream from cerebral amyloid deposition, and identifies key inter-subsystem connections for deep imaging and neuropathologic characterization.http://link.springer.com/article/10.1186/s40035-020-0186-4Alzheimer’s diseaseCognitive impairmentFunctional connectivityDefault mode networkDisparities |
| spellingShingle | Maria B. Misiura J. Christina Howell Junjie Wu Deqiang Qiu Monica W. Parker Jessica A. Turner William T. Hu Race modifies default mode connectivity in Alzheimer’s disease Translational Neurodegeneration Alzheimer’s disease Cognitive impairment Functional connectivity Default mode network Disparities |
| title | Race modifies default mode connectivity in Alzheimer’s disease |
| title_full | Race modifies default mode connectivity in Alzheimer’s disease |
| title_fullStr | Race modifies default mode connectivity in Alzheimer’s disease |
| title_full_unstemmed | Race modifies default mode connectivity in Alzheimer’s disease |
| title_short | Race modifies default mode connectivity in Alzheimer’s disease |
| title_sort | race modifies default mode connectivity in alzheimer s disease |
| topic | Alzheimer’s disease Cognitive impairment Functional connectivity Default mode network Disparities |
| url | http://link.springer.com/article/10.1186/s40035-020-0186-4 |
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