Effect of birth asphyxia on neonatal blood glucose during the early postnatal life: A multi-center study in Hubei Province, China
Background: Birth asphyxia causes hypoxia or inadequate perfusion to the organs of newborns, leading to metabolism dysfunctions including blood glucose disorders. Methods: Neonates with and without birth asphyxia were retrospectively recruited from 53 hospitals in Hubei Province from January 1 to De...
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Elsevier
2023-09-01
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| Series: | Pediatrics and Neonatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957223000566 |
| _version_ | 1827805424899850240 |
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| author | Chun-Hua Liu Hong-Yan Liu Si-Cong Peng Sha Pan Zhi-Ting Wan Su-Ying Wu Chao-Ce Fang Rong Jiao Wen-Xiang Wang Bin Gan Shu-JieYang Ju-Fang Tan Xiao-Fang Zhu Ping-Li She Qi-Hong Fan Min Yang Ji-Jian Xie Jie Sun Ling Zeng Lian-Hong Zhang Hui-Rong Xu Yan-Ni Li Ping-Feng Zhang Wei Lu Xian-Tao Yang Xiong-Fei Xiao Hong-Li Li Zheng-Liang Rao Chuang Gao Ya-Hui Luo Hong Chen Ming-Jin Yu Xiao-Ying Luan Yu-Rong Huang Shi-Wen Xia |
| author_facet | Chun-Hua Liu Hong-Yan Liu Si-Cong Peng Sha Pan Zhi-Ting Wan Su-Ying Wu Chao-Ce Fang Rong Jiao Wen-Xiang Wang Bin Gan Shu-JieYang Ju-Fang Tan Xiao-Fang Zhu Ping-Li She Qi-Hong Fan Min Yang Ji-Jian Xie Jie Sun Ling Zeng Lian-Hong Zhang Hui-Rong Xu Yan-Ni Li Ping-Feng Zhang Wei Lu Xian-Tao Yang Xiong-Fei Xiao Hong-Li Li Zheng-Liang Rao Chuang Gao Ya-Hui Luo Hong Chen Ming-Jin Yu Xiao-Ying Luan Yu-Rong Huang Shi-Wen Xia |
| author_sort | Chun-Hua Liu |
| collection | DOAJ |
| description | Background: Birth asphyxia causes hypoxia or inadequate perfusion to the organs of newborns, leading to metabolism dysfunctions including blood glucose disorders. Methods: Neonates with and without birth asphyxia were retrospectively recruited from 53 hospitals in Hubei Province from January 1 to December 31, 2018. In summary, 875, 1139, and 180 cases in the control group, the mild asphyxia group, and the severe asphyxia group were recruited, respectively. Neonatal blood glucose values at postnatal 1, 2, 6, and 12 h (time error within 0.5 h was allowed) were gathered from the medical records. Results: The incidence rates of hyperglycemia in the control group, the mild asphyxia group and the severe asphyxia group were 2.97%, 7.90%, and 23.33%, respectively (p < 0.001). Additionally, the incidence rates of hypoglycemia in the three groups above were 3.66%, 4.13%, and 7.78%, respectively (p = 0.042). The blood glucose values of neonates with hypoglycemia in the asphyxia group were lower than in the control group (p = 0.003). Furthermore, the blood glucose values of neonates with hyperglycemia were highest in the severe asphyxia group (p < 0.001). There were 778 and 117 cases with blood glucose records at four predefined time points in the mild and severe asphyxia group, respectively. The incidence of blood glucose disorders in the mild asphyxia group significantly decreased from postnatal 6 h (p＜0.05). However, we found no obvious changes of the incidence of glucose disorders within postnatal 12 h in the severe asphyxia group (p = 0.589). Conclusion: Birth asphyxia is likely to cause neonatal blood glucose disorders, both hypoglycemia and hyperglycemia, during the early postnatal life. The neonates with severe asphyxia have higher incidence, worse severity and longer duration of blood glucose disorders than neonates with mild asphyxia. |
| first_indexed | 2024-03-11T21:25:21Z |
| format | Article |
| id | doaj.art-e6b5102bb2344d658b114e48b77ae691 |
| institution | Directory Open Access Journal |
| issn | 1875-9572 |
| language | English |
| last_indexed | 2024-03-11T21:25:21Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj.art-e6b5102bb2344d658b114e48b77ae6912023-09-28T05:25:12ZengElsevierPediatrics and Neonatology1875-95722023-09-01645562569Effect of birth asphyxia on neonatal blood glucose during the early postnatal life: A multi-center study in Hubei Province, ChinaChun-Hua Liu0Hong-Yan Liu1Si-Cong Peng2Sha Pan3Zhi-Ting Wan4Su-Ying Wu5Chao-Ce Fang6Rong Jiao7Wen-Xiang Wang8Bin Gan9 Shu-JieYang10Ju-Fang Tan11Xiao-Fang Zhu12Ping-Li She13Qi-Hong Fan14Min Yang15Ji-Jian Xie16Jie Sun17Ling Zeng18Lian-Hong Zhang19Hui-Rong Xu20Yan-Ni Li21Ping-Feng Zhang22Wei Lu23Xian-Tao Yang24Xiong-Fei Xiao25Hong-Li Li26Zheng-Liang Rao27Chuang Gao28Ya-Hui Luo29Hong Chen30Ming-Jin Yu31Xiao-Ying Luan32Yu-Rong Huang33Shi-Wen Xia34Department of Neonatology, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Neonatology, Xianning Central Hospital, First Affiliated Hospital of Hubei University of Science and Technology, Xianning, China; School of Medicine, Wuhan University of Science and Technology, Wuhan, ChinaDepartment of Neonatology, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Neonatology, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Neonatology, Xianning Central Hospital, First Affiliated Hospital of Hubei University of Science and Technology, Xianning, ChinaDepartment of Neonatology, Xianning Central Hospital, First Affiliated Hospital of Hubei University of Science and Technology, Xianning, ChinaDepartment of Neonatology, University Hospital of Hubei Minzu University, Enshi, ChinaDepartment of Neonatology, University Hospital of Hubei Minzu University, Enshi, ChinaDepartment of Pediatrics, Xiangyang NO.1 People's Hospital, Xiangyang, ChinaDepartment of Pediatrics, Xiangyang NO.1 People's Hospital, Xiangyang, ChinaDepartment of Neonatology, The Central Hospital of Xiaogan, Xiaogan, ChinaDepartment of Neonatology, The Central Hospital of Xiaogan, Xiaogan, ChinaDepartment of Neonatology, Jingzhou Central Hospital, Jingzhou, ChinaDepartment of Neonatology, Jingzhou Central Hospital, Jingzhou, ChinaDepartment of Neonatology, The First People's Hospital of Jingzhou, Jingzhou, ChinaDepartment of Neonatology, The First People's Hospital of Jingzhou, Jingzhou, ChinaDepartment of Pediatrics, Children's Medical Center, Affiliated Taihe Hospital of Hubei University of Medicine, Shiyan, ChinaDepartment of Pediatrics, Children's Medical Center, Affiliated Taihe Hospital of Hubei University of Medicine, Shiyan, ChinaDepartment of Neonatology, Huanggang Central Hospital, Huanggang, ChinaDepartment of Neonatology, Huanggang Central Hospital, Huanggang, ChinaDepartment of Neonatology, The First People's Hospital of Tianmen, Tianmen, ChinaDepartment of Neonatology, The First People's Hospital of Tianmen, Tianmen, ChinaDepartment of Pediatrics, Xiangyang Maternal and Child Health Care Hospital, Xiangyang, ChinaDepartment of Pediatrics, Xiangyang Maternal and Child Health Care Hospital, Xiangyang, ChinaDepartment of Pediatrics, Yichang Central People's Hospital, Yichang, ChinaDepartment of Pediatrics, Yichang Central People's Hospital, Yichang, ChinaDepartment of Neonatology, Tianmen Maternal and Child Health Care Hospital, Tianmen, ChinaDepartment of Pediatrics, Hanchuan Maternal and Child Health and Family Planning Service Center, Hanchuan, ChinaDepartment of Pediatrics, Yingshan People's Hospital, Yingshan, ChinaDepartment of Pediatrics, Yingshan People's Hospital, Yingshan, ChinaDepartment of Neonatology, Hanchuan People's Hospital, Hanchuan, ChinaDepartment of Neonatology, Qichun People's Hospital, Qichun, ChinaDepartment of Neonatology, Qichun People's Hospital, Qichun, ChinaDepartment of Pediatrics, Yunmeng Hospital of Traditional Chinese Medicine, Yunmeng, ChinaDepartment of Pediatrics, Gong An County People's Hospital, Gong'an, ChinaDepartment of Neonatology, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Corresponding author. Department of Neonatology, Maternal and Child Health Hospital of Hubei Province, No. 745 Wuluo Road, Hongshan District, Wuhan 430070, China.Background: Birth asphyxia causes hypoxia or inadequate perfusion to the organs of newborns, leading to metabolism dysfunctions including blood glucose disorders. Methods: Neonates with and without birth asphyxia were retrospectively recruited from 53 hospitals in Hubei Province from January 1 to December 31, 2018. In summary, 875, 1139, and 180 cases in the control group, the mild asphyxia group, and the severe asphyxia group were recruited, respectively. Neonatal blood glucose values at postnatal 1, 2, 6, and 12 h (time error within 0.5 h was allowed) were gathered from the medical records. Results: The incidence rates of hyperglycemia in the control group, the mild asphyxia group and the severe asphyxia group were 2.97%, 7.90%, and 23.33%, respectively (p < 0.001). Additionally, the incidence rates of hypoglycemia in the three groups above were 3.66%, 4.13%, and 7.78%, respectively (p = 0.042). The blood glucose values of neonates with hypoglycemia in the asphyxia group were lower than in the control group (p = 0.003). Furthermore, the blood glucose values of neonates with hyperglycemia were highest in the severe asphyxia group (p < 0.001). There were 778 and 117 cases with blood glucose records at four predefined time points in the mild and severe asphyxia group, respectively. The incidence of blood glucose disorders in the mild asphyxia group significantly decreased from postnatal 6 h (p＜0.05). However, we found no obvious changes of the incidence of glucose disorders within postnatal 12 h in the severe asphyxia group (p = 0.589). Conclusion: Birth asphyxia is likely to cause neonatal blood glucose disorders, both hypoglycemia and hyperglycemia, during the early postnatal life. The neonates with severe asphyxia have higher incidence, worse severity and longer duration of blood glucose disorders than neonates with mild asphyxia.http://www.sciencedirect.com/science/article/pii/S1875957223000566Blood glucoseHyperglycemiaHypoglycemiaNeonate |
| spellingShingle | Chun-Hua Liu Hong-Yan Liu Si-Cong Peng Sha Pan Zhi-Ting Wan Su-Ying Wu Chao-Ce Fang Rong Jiao Wen-Xiang Wang Bin Gan Shu-JieYang Ju-Fang Tan Xiao-Fang Zhu Ping-Li She Qi-Hong Fan Min Yang Ji-Jian Xie Jie Sun Ling Zeng Lian-Hong Zhang Hui-Rong Xu Yan-Ni Li Ping-Feng Zhang Wei Lu Xian-Tao Yang Xiong-Fei Xiao Hong-Li Li Zheng-Liang Rao Chuang Gao Ya-Hui Luo Hong Chen Ming-Jin Yu Xiao-Ying Luan Yu-Rong Huang Shi-Wen Xia Effect of birth asphyxia on neonatal blood glucose during the early postnatal life: A multi-center study in Hubei Province, China Pediatrics and Neonatology Blood glucose Hyperglycemia Hypoglycemia Neonate |
| title | Effect of birth asphyxia on neonatal blood glucose during the early postnatal life: A multi-center study in Hubei Province, China |
| title_full | Effect of birth asphyxia on neonatal blood glucose during the early postnatal life: A multi-center study in Hubei Province, China |
| title_fullStr | Effect of birth asphyxia on neonatal blood glucose during the early postnatal life: A multi-center study in Hubei Province, China |
| title_full_unstemmed | Effect of birth asphyxia on neonatal blood glucose during the early postnatal life: A multi-center study in Hubei Province, China |
| title_short | Effect of birth asphyxia on neonatal blood glucose during the early postnatal life: A multi-center study in Hubei Province, China |
| title_sort | effect of birth asphyxia on neonatal blood glucose during the early postnatal life a multi center study in hubei province china |
| topic | Blood glucose Hyperglycemia Hypoglycemia Neonate |
| url | http://www.sciencedirect.com/science/article/pii/S1875957223000566 |
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