Antibacterial Evaluation, In Silico Characters and Molecular Docking of Schiff Bases Derived from 5-aminopyrazoles

Antibacterial Evaluation, In Silico Characters and Molecular Docking of Schiff Bases Derived from 5-aminopyrazoles

A series of Schiff bases <b>14</b>–<b>25</b> were designed and synthesized for evaluation of their antibacterial properties against multi-drug resistant bacteria (MDRB). The antibacterial activities of Schiff bases <b>14</b>–<b>25</b> showed that most...

Full description

Bibliographic Details
Main Authors:	Ashraf S. Hassan, Ahmed A. Askar, Eman S. Nossier, Ahmed M. Naglah, Gaber O. Moustafa, Mohamed A. Al-Omar
Format:	Article
Language:	English
Published:	MDPI AG 2019-08-01
Series:	Molecules
Subjects:	Schiff bases Antibacterial 5-Aminopyrazole <i>Staphylococcus aureus</i> DNA gyrase Dihydrofolate reductase Molecular docking
Online Access:	https://www.mdpi.com/1420-3049/24/17/3130

Similar Items

Regioselectivity in the multicomponent reaction of 5-aminopyrazoles, cyclic 1,3-diketones and dimethylformamide dimethylacetal under controlled microwave heating
by: Kamal Usef Sadek, et al.
Published: (2012-01-01)

Cyanothioacetamides as a synthetic platform for the synthesis of aminopyrazole derivatives
by: Valeriy O. Filimonov, et al.
Published: (2023-08-01)

Approaches towards the synthesis of 5-aminopyrazoles
by: Ranjana Aggarwal, et al.
Published: (2011-02-01)

5-Aminopyrazole as precursor in design and synthesis of fused pyrazoloazines
by: Ranjana Aggarwal, et al.
Published: (2018-01-01)

Synthesis of functionalized aminopyrazole and pyrazolopyrimidine derivatives: Molecular modeling and docking as anticancer agents
by: Aisha Hossan, et al.
Published: (2023-04-01)

Screening potential inhibitor from actinomycetes for Dihydrofolate reductase of Staphylococcus aureus – In vitro and in silico studies
by: Sharmila Velusamy, et al.
Published: (2023-08-01)

Enaminonitriles in Heterocyclic Synthesis: A Route to 1,3-Diaryl-4-aminopyrazole Derivatives
by: Abdellatif Mohamed Salaheldin, et al.
Published: (2013-01-01)

The Anti-Multidrug-Resistant <i>Acinetobacter baumannii</i> Study on 1,3-diamino-7H-pyrrolo[3,2-f]quinazoline Compounds
by: Han Wu, et al.
Published: (2022-12-01)

Evidence of Pyrimethamine and Cycloguanil Analogues as Dual Inhibitors of <i>Trypanosoma brucei</i> Pteridine Reductase and Dihydrofolate Reductase
by: Giusy Tassone, et al.
Published: (2021-06-01)

Design, Synthesis, and Molecular Docking Study of Novel Heterocycles Incorporating 1,3,4-Thiadiazole Moiety as Potential Antimicrobial and Anticancer Agents
by: Mohamed El-Naggar, et al.
Published: (2019-03-01)

A calibration curve for immobilized dihydrofolate reductase activity assay
by: Priyanka Singh, et al.
Published: (2015-09-01)

Identification of Antibacterial Metabolites from Endophytic Fungus <i>Aspergillus fumigatus,</i> Isolated from <i>Albizia lucidior</i> Leaves (Fabaceae), Utilizing Metabolomic and Molecular Docking Techniques
by: Mai E. Hussein, et al.
Published: (2022-02-01)

Unveiling the Efficacy of Sesquiterpenes from Marine Sponge <i>Dactylospongia elegans</i> in Inhibiting Dihydrofolate Reductase Using Docking and Molecular Dynamic Studies
by: Abdelsattar M. Omar, et al.
Published: (2023-01-01)

INHIBITORY ACTIVITY OF SOME MARINE SPONGE EXTRACTS FROM URABÁ GULF ON DIHYDROFOLATE REDUCTASE ENZYME
by: Diego A. ZABALA, et al.
Published: (2009-02-01)

In Silico and In Vitro Search for Dual Inhibitors of the <i>Trypanosoma brucei</i> and <i>Leishmania major</i> Pteridine Reductase 1 and Dihydrofolate Reductase
by: Katharina Possart, et al.
Published: (2023-11-01)

The Complementarity Principle—One More Step towards Analytical Docking on the Example of Dihydrofolate Reductase Complexes
by: Vladimir Potemkin, et al.
Published: (2021-09-01)

Synthesis, Antimicrobial Activity and Molecular Docking of Novel Thiourea Derivatives Tagged with Thiadiazole, Imidazole and Triazine Moieties as Potential DNA Gyrase and Topoisomerase IV Inhibitors
by: Heba E. Hashem, et al.
Published: (2020-06-01)

Dihydrofolate Reductase Is a Valid Target for Antifungal Development in the Human Pathogen <italic toggle="yes">Candida albicans</italic>
by: Christian DeJarnette, et al.
Published: (2020-06-01)

Synthesis of 4-Aminopyrazol-5-ols as Edaravone Analogs and Their Antioxidant Activity
by: Yanina V. Burgart, et al.
Published: (2022-11-01)

In Ovo and In Silico Evaluation of the Anti-Angiogenic Potential of Syringin
by: Aventurado CA, et al.
Published: (2020-11-01)

Structure and IR Spectra of 3(5)-Aminopyrazoles and UV-Induced Tautomerization in Argon Matrix
by: Alina Secrieru, et al.
Published: (2021-07-01)

Discovery of New Schiff Bases Tethered Pyrazole Moiety: Design, Synthesis, Biological Evaluation, and Molecular Docking Study as Dual Targeting DHFR/DNA Gyrase Inhibitors with Immunomodulatory Activity
by: Ashraf S. Hassan, et al.
Published: (2020-06-01)

The Computational Calculation and Molecular Docking of Aeroplysinin-1 As Antibacterial
by: Mirella Fonda Maahury, et al.
Published: (2021-09-01)

Type 2 antifolates in the chemotherapy of falciparum malaria
by: Delfino Reinaldo T., et al.
Published: (2002-01-01)

A New PCR-Based Assay for Testing Bronchoalveolar Lavage Fluid Samples from Patients with Suspected <i>Pneumocystis jirovecii</i> Pneumonia
by: Flora Marzia Liotti, et al.
Published: (2021-08-01)

New one-pot synthesis of 4-arylpyrazolo[3,4-b]pyridin-6-ones based on 5-aminopyrazoles and azlactones
by: Vladislav Yu. Shuvalov, et al.
Published: (2023-08-01)

Synthesis, Spectral Characteristics, and Molecular Docking Studies of 2,4-Dichloro-<i>N</i>-(2,2,2-trichloro-1-((5-(phenylamino)-1,3,4-thiadiazol-2-yl)amino)ethyl)benzamide
by: Valeriia V. Pavlova, et al.
Published: (2022-11-01)

Ambient-Temperature Synthesis of (<i>E</i>)-<i>N</i>-(3-(<i>tert</i>-Butyl)-1-methyl-1<i>H</i>-pyrazol-5-yl)-1-(pyridin-2-yl)methanimine
by: Diana Becerra, et al.
Published: (2021-07-01)

Dihydrofolate Reductase I164L Mutation in Plasmodium falciparum, Madagascar
by: Didier Ménard, et al.
Published: (2008-07-01)

Development of antibacterial compounds that constrain evolutionary pathways to resistance
by: Yanmin Zhang, et al.
Published: (2021-07-01)

Mechanism of Action of Methotrexate Against Zika Virus
by: Sungjun Beck, et al.
Published: (2019-04-01)

Factors Influencing the Antifolate Activity of Synthetic Tea-Derived Catechins
by: José Neptuno Rodríguez-López, et al.
Published: (2013-07-01)

Investigation of Spectra and Ionization Constants of 8-Alkyl Pterins by Fluorimetry
by: Jeong Soon-Seog, et al.
Published: (1993-02-01)

Extraction of ursolic acid from Ocimum sanctum and synthesis of its novel derivatives: effects on extracellular homocysteine, dihydrofolate reductase activity and proliferation of HepG2 human hepatoma cells
by: Batra Apsara, et al.
Published: (2013-12-01)

Sesquiterpene Lactones with Dual Inhibitory Activity against the <i>Trypanosoma brucei</i> Pteridine Reductase 1 and Dihydrofolate Reductase
by: Katharina Possart, et al.
Published: (2021-12-01)

Discovery of novel indene-based hybrids as breast cancer inhibitors targeting Hsp90: Synthesis, bio-evaluation and molecular docking study
by: Amal M. Alosaimy, et al.
Published: (2023-04-01)

Synthesis, spectral characterization, redox and antimicrobial activity of Schiff base transition metal(II) complexes derived from 4-aminoantipyrine and 3-salicylideneacetylacetone
by: Raman Natarajan, et al.
Published: (2005-09-01)

In Silico Study Identified Methotrexate Analog as Potential Inhibitor of Drug Resistant Human Dihydrofolate Reductase for Cancer Therapeutics
by: Rabia Mukhtar Rana, et al.
Published: (2020-07-01)

Revisiting methotrexate and phototrexate Zinc15 library-based derivatives using deep learning in-silico drug design approach
by: Farhan Siddique, et al.
Published: (2024-03-01)

New Quinazolin-4(3<i>H</i>)-one Derivatives Incorporating Hydrazone and Pyrazole Scaffolds as Antimicrobial Agents Targeting DNA Gyraze Enzyme
by: Eman M. Mohi El-Deen, et al.
Published: (2022-08-01)