Associations of Depressive Symptoms with Subjective Cognitive Decline in Elderly People—A Cross-Sectional Analysis from the AgeWell.de-Study
To develop effective dementia prevention strategies, it is necessary to understand risk factors, associated factors and early signs of dementia. Subjective cognitive decline (SCD) is the earliest form of dementia. The aim of this study is to assess depression as a factor that is significantly associ...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/16/5205 |
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| author | Isabel Zöllinger Alexander Bauer Iris Blotenberg Christian Brettschneider Maresa Buchholz David Czock Juliane Döhring Catharina Escales Thomas Fankhaenel Thomas Frese Wolfgang Hoffmann Hanna Kaduszkiewicz Hans-Helmut König Melanie Luppa Anke Oey Alexander Pabst Linda Sanftenberg Jochen René Thyrian Julian Weiss Flora Wendel Birgitt Wiese Steffi G. Riedel-Heller Jochen Gensichen |
| author_facet | Isabel Zöllinger Alexander Bauer Iris Blotenberg Christian Brettschneider Maresa Buchholz David Czock Juliane Döhring Catharina Escales Thomas Fankhaenel Thomas Frese Wolfgang Hoffmann Hanna Kaduszkiewicz Hans-Helmut König Melanie Luppa Anke Oey Alexander Pabst Linda Sanftenberg Jochen René Thyrian Julian Weiss Flora Wendel Birgitt Wiese Steffi G. Riedel-Heller Jochen Gensichen |
| author_sort | Isabel Zöllinger |
| collection | DOAJ |
| description | To develop effective dementia prevention strategies, it is necessary to understand risk factors, associated factors and early signs of dementia. Subjective cognitive decline (SCD) is the earliest form of dementia. The aim of this study is to assess depression as a factor that is significantly associated with SCD. The data of 1030 general practitioner patients from the AgeWell.de-study (60–77 years; CAIDE dementia risk score ≥ 9) were analysed. A descriptive analysis was conducted using validated instruments like the Geriatric depression scale (GDS), Lubben social network scale (LSNS-6) and education classes according to CASMIN (Comparative Analysis of Social Mobility in Industrial Nations). A multivariate regression model with the dependent variable SCD was calculated. Of the 1030 participants, 5.9% had depressive symptoms and 31.3% SCD. The group with depressive symptoms showed significantly higher body-mass-index (<i>p</i> = 0.005), lower education class (<i>p</i> = 0.022), lower LSNS-6 score (<i>p</i> < 0.001), higher sports activity (<i>p</i> < 0.001), and more sleeping problems (<i>p</i> = 0.026). In the regression model a higher GDS-score [Odds ratio (OR): 1.219 (<i>p</i> < 0.001)], more sleeping problems [OR: 1.550 (<i>p</i> = 0.017)] and higher education class [middle/high: OR: 1.474/1.875 (<i>p</i> = 0.037/0.004)] were significantly associated with SCD. This study identified depressive symptoms, sleeping problems, and higher education classes as factors associated with SCD, which can represent an early form of dementia. |
| first_indexed | 2024-03-10T23:50:57Z |
| format | Article |
| id | doaj.art-e6b94c17957d414b8677e7fa9fcae0bd |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T23:50:57Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-e6b94c17957d414b8677e7fa9fcae0bd2023-11-19T01:39:26ZengMDPI AGJournal of Clinical Medicine2077-03832023-08-011216520510.3390/jcm12165205Associations of Depressive Symptoms with Subjective Cognitive Decline in Elderly People—A Cross-Sectional Analysis from the AgeWell.de-StudyIsabel Zöllinger0Alexander Bauer1Iris Blotenberg2Christian Brettschneider3Maresa Buchholz4David Czock5Juliane Döhring6Catharina Escales7Thomas Fankhaenel8Thomas Frese9Wolfgang Hoffmann10Hanna Kaduszkiewicz11Hans-Helmut König12Melanie Luppa13Anke Oey14Alexander Pabst15Linda Sanftenberg16Jochen René Thyrian17Julian Weiss18Flora Wendel19Birgitt Wiese20Steffi G. Riedel-Heller21Jochen Gensichen22Institute of General Practice and Family Medicine, University Hospital of LMU Munich, 80336 Munich, GermanyInstitute of General Practice and Family Medicine, Martin-Luther-University Halle-Wittenberg, 06112 Halle, GermanyGerman Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, 17489 Greifswald, GermanyDepartment of Health Economics and Health Services Research, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, GermanyGerman Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, 17489 Greifswald, GermanyDepartment of Clinical Pharmacology and Pharmacoepidemiology, University Hospital Heidelberg, 69120 Heidelberg, GermanyInstitute of General Practice, University of Kiel, 24105 Kiel, GermanyInstitute of General Practice, University of Kiel, 24105 Kiel, GermanyInstitute of General Practice and Family Medicine, Martin-Luther-University Halle-Wittenberg, 06112 Halle, GermanyInstitute of General Practice and Family Medicine, Martin-Luther-University Halle-Wittenberg, 06112 Halle, GermanyGerman Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, 17489 Greifswald, GermanyInstitute of General Practice, University of Kiel, 24105 Kiel, GermanyDepartment of Health Economics and Health Services Research, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, GermanyInstitute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of Leipzig, 04103 Leipzig, GermanyState Health Department of Lower Saxony, 30449 Hannover, GermanyInstitute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of Leipzig, 04103 Leipzig, GermanyInstitute of General Practice and Family Medicine, University Hospital of LMU Munich, 80336 Munich, GermanyGerman Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, 17489 Greifswald, GermanyInstitute of General Practice and Family Medicine, University Hospital of LMU Munich, 80336 Munich, GermanyInstitute of General Practice and Family Medicine, University Hospital of LMU Munich, 80336 Munich, GermanyWork Group Medical Statistics and IT-Infrastructure, Institute for General Practice, Hannover Medical School, 30625 Hannover, GermanyInstitute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of Leipzig, 04103 Leipzig, GermanyInstitute of General Practice and Family Medicine, University Hospital of LMU Munich, 80336 Munich, GermanyTo develop effective dementia prevention strategies, it is necessary to understand risk factors, associated factors and early signs of dementia. Subjective cognitive decline (SCD) is the earliest form of dementia. The aim of this study is to assess depression as a factor that is significantly associated with SCD. The data of 1030 general practitioner patients from the AgeWell.de-study (60–77 years; CAIDE dementia risk score ≥ 9) were analysed. A descriptive analysis was conducted using validated instruments like the Geriatric depression scale (GDS), Lubben social network scale (LSNS-6) and education classes according to CASMIN (Comparative Analysis of Social Mobility in Industrial Nations). A multivariate regression model with the dependent variable SCD was calculated. Of the 1030 participants, 5.9% had depressive symptoms and 31.3% SCD. The group with depressive symptoms showed significantly higher body-mass-index (<i>p</i> = 0.005), lower education class (<i>p</i> = 0.022), lower LSNS-6 score (<i>p</i> < 0.001), higher sports activity (<i>p</i> < 0.001), and more sleeping problems (<i>p</i> = 0.026). In the regression model a higher GDS-score [Odds ratio (OR): 1.219 (<i>p</i> < 0.001)], more sleeping problems [OR: 1.550 (<i>p</i> = 0.017)] and higher education class [middle/high: OR: 1.474/1.875 (<i>p</i> = 0.037/0.004)] were significantly associated with SCD. This study identified depressive symptoms, sleeping problems, and higher education classes as factors associated with SCD, which can represent an early form of dementia.https://www.mdpi.com/2077-0383/12/16/5205depressionelderlysubjective cognitive declinedementia |
| spellingShingle | Isabel Zöllinger Alexander Bauer Iris Blotenberg Christian Brettschneider Maresa Buchholz David Czock Juliane Döhring Catharina Escales Thomas Fankhaenel Thomas Frese Wolfgang Hoffmann Hanna Kaduszkiewicz Hans-Helmut König Melanie Luppa Anke Oey Alexander Pabst Linda Sanftenberg Jochen René Thyrian Julian Weiss Flora Wendel Birgitt Wiese Steffi G. Riedel-Heller Jochen Gensichen Associations of Depressive Symptoms with Subjective Cognitive Decline in Elderly People—A Cross-Sectional Analysis from the AgeWell.de-Study Journal of Clinical Medicine depression elderly subjective cognitive decline dementia |
| title | Associations of Depressive Symptoms with Subjective Cognitive Decline in Elderly People—A Cross-Sectional Analysis from the AgeWell.de-Study |
| title_full | Associations of Depressive Symptoms with Subjective Cognitive Decline in Elderly People—A Cross-Sectional Analysis from the AgeWell.de-Study |
| title_fullStr | Associations of Depressive Symptoms with Subjective Cognitive Decline in Elderly People—A Cross-Sectional Analysis from the AgeWell.de-Study |
| title_full_unstemmed | Associations of Depressive Symptoms with Subjective Cognitive Decline in Elderly People—A Cross-Sectional Analysis from the AgeWell.de-Study |
| title_short | Associations of Depressive Symptoms with Subjective Cognitive Decline in Elderly People—A Cross-Sectional Analysis from the AgeWell.de-Study |
| title_sort | associations of depressive symptoms with subjective cognitive decline in elderly people a cross sectional analysis from the agewell de study |
| topic | depression elderly subjective cognitive decline dementia |
| url | https://www.mdpi.com/2077-0383/12/16/5205 |
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