EIF4A inhibition targets bioenergetic homeostasis in AML MOLM-14 cells in vitro and in vivo and synergizes with cytarabine and venetoclax
Abstract Background Acute myeloid leukemia (AML) is an aggressive hematological cancer resulting from uncontrolled proliferation of differentiation-blocked myeloid cells. Seventy percent of AML patients are currently not cured with available treatments, highlighting the need of novel therapeutic str...
Main Authors: | Katie Fooks, Gabriela Galicia-Vazquez, Victor Gife, Alejandro Schcolnik-Cabrera, Zaynab Nouhi, William W. L. Poon, Vincent Luo, Ryan N. Rys, Raquel Aloyz, Alexandre Orthwein, Nathalie A. Johnson, Laura Hulea, Francois E. Mercier |
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Format: | Article |
Language: | English |
Published: |
BMC
2022-12-01
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Series: | Journal of Experimental & Clinical Cancer Research |
Subjects: | |
Online Access: | https://doi.org/10.1186/s13046-022-02542-8 |
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