Bizarre parosteal osteochondromatous proliferation: an educational review
Abstract Bizarre parosteal osteochondromatous proliferation (BPOP) is a surface-based bone lesion belonging to the group of benign chondrogenic tumors. The aim of this review is to familiarize the readers with imaging features and differential diagnosis of BPOP, also addressing pathological presenta...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-06-01
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| Series: | Insights into Imaging |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13244-023-01455-0 |
| _version_ | 1797795682164146176 |
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| author | Salvatore Gitto Francesca Serpi Carmelo Messina Domenico Albano Andrea Di Bernardo Elisabetta Armiraglio Luca Cannavò Simone Mazzoli Alessandro Luzzati Antonina Parafioriti Luca Maria Sconfienza |
| author_facet | Salvatore Gitto Francesca Serpi Carmelo Messina Domenico Albano Andrea Di Bernardo Elisabetta Armiraglio Luca Cannavò Simone Mazzoli Alessandro Luzzati Antonina Parafioriti Luca Maria Sconfienza |
| author_sort | Salvatore Gitto |
| collection | DOAJ |
| description | Abstract Bizarre parosteal osteochondromatous proliferation (BPOP) is a surface-based bone lesion belonging to the group of benign chondrogenic tumors. The aim of this review is to familiarize the readers with imaging features and differential diagnosis of BPOP, also addressing pathological presentation and treatment options. The peak of incidence of BPOP is in the third and fourth decades of life, although it can occur at any age. Hands are the most common location of BPOP (55%), followed by feet (15%) and long bones (25%). On imaging, BPOP appears as a well-marginated mass of heterotopic mineralization arising from the periosteal aspect of the bone. Typical features of BPOP are contiguity with the underlying bone and lack of cortico-medullary continuity, although cortical interruption and medullary involvement have been rarely reported. Histologically, BPOP is a benign bone surface lesion characterized by osteocartilaginous proliferation with disorganized admixture of cartilage with bizarre features, bone and spindle cells. Differential diagnosis includes both benign—such as florid reactive periostitis, osteochondroma, subungual exostosis, periosteal chondroma and myositis ossificans—and malignant lesions—such as periosteal chondrosarcoma and surface-based osteosarcoma. Treatment consists of surgical resection. Local recurrences are common and treated with re-excision. Critical relevance statement Bizarre parosteal osteochondromatous proliferation is a benign mineralized mass arising from the periosteal aspect of bone cortex. Multi-modality imaging characteristics, pathology features and differential diagnosis are here highlighted to familiarize the readers with this entity and offer optimal patient care. |
| first_indexed | 2024-03-13T03:21:41Z |
| format | Article |
| id | doaj.art-e6bc393a2dd641b8ad5760053400927b |
| institution | Directory Open Access Journal |
| issn | 1869-4101 |
| language | English |
| last_indexed | 2024-03-13T03:21:41Z |
| publishDate | 2023-06-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Insights into Imaging |
| spelling | doaj.art-e6bc393a2dd641b8ad5760053400927b2023-06-25T11:19:23ZengSpringerOpenInsights into Imaging1869-41012023-06-0114111210.1186/s13244-023-01455-0Bizarre parosteal osteochondromatous proliferation: an educational reviewSalvatore Gitto0Francesca Serpi1Carmelo Messina2Domenico Albano3Andrea Di Bernardo4Elisabetta Armiraglio5Luca Cannavò6Simone Mazzoli7Alessandro Luzzati8Antonina Parafioriti9Luca Maria Sconfienza10IRCCS Istituto Ortopedico GaleazziDipartimento di Scienze Biomediche per la Salute, Università degli Studi di MilanoIRCCS Istituto Ortopedico GaleazziIRCCS Istituto Ortopedico GaleazziPathology Department, ASST Pini-CTOPathology Department, ASST Pini-CTOIRCCS Istituto Ortopedico GaleazziIRCCS Istituto Ortopedico GaleazziIRCCS Istituto Ortopedico GaleazziPathology Department, ASST Pini-CTOIRCCS Istituto Ortopedico GaleazziAbstract Bizarre parosteal osteochondromatous proliferation (BPOP) is a surface-based bone lesion belonging to the group of benign chondrogenic tumors. The aim of this review is to familiarize the readers with imaging features and differential diagnosis of BPOP, also addressing pathological presentation and treatment options. The peak of incidence of BPOP is in the third and fourth decades of life, although it can occur at any age. Hands are the most common location of BPOP (55%), followed by feet (15%) and long bones (25%). On imaging, BPOP appears as a well-marginated mass of heterotopic mineralization arising from the periosteal aspect of the bone. Typical features of BPOP are contiguity with the underlying bone and lack of cortico-medullary continuity, although cortical interruption and medullary involvement have been rarely reported. Histologically, BPOP is a benign bone surface lesion characterized by osteocartilaginous proliferation with disorganized admixture of cartilage with bizarre features, bone and spindle cells. Differential diagnosis includes both benign—such as florid reactive periostitis, osteochondroma, subungual exostosis, periosteal chondroma and myositis ossificans—and malignant lesions—such as periosteal chondrosarcoma and surface-based osteosarcoma. Treatment consists of surgical resection. Local recurrences are common and treated with re-excision. Critical relevance statement Bizarre parosteal osteochondromatous proliferation is a benign mineralized mass arising from the periosteal aspect of bone cortex. Multi-modality imaging characteristics, pathology features and differential diagnosis are here highlighted to familiarize the readers with this entity and offer optimal patient care.https://doi.org/10.1186/s13244-023-01455-0Bizarre parosteal osteochondromatous proliferationCartilaginous tumorPeriostitisNora lesionOsteochondroma |
| spellingShingle | Salvatore Gitto Francesca Serpi Carmelo Messina Domenico Albano Andrea Di Bernardo Elisabetta Armiraglio Luca Cannavò Simone Mazzoli Alessandro Luzzati Antonina Parafioriti Luca Maria Sconfienza Bizarre parosteal osteochondromatous proliferation: an educational review Insights into Imaging Bizarre parosteal osteochondromatous proliferation Cartilaginous tumor Periostitis Nora lesion Osteochondroma |
| title | Bizarre parosteal osteochondromatous proliferation: an educational review |
| title_full | Bizarre parosteal osteochondromatous proliferation: an educational review |
| title_fullStr | Bizarre parosteal osteochondromatous proliferation: an educational review |
| title_full_unstemmed | Bizarre parosteal osteochondromatous proliferation: an educational review |
| title_short | Bizarre parosteal osteochondromatous proliferation: an educational review |
| title_sort | bizarre parosteal osteochondromatous proliferation an educational review |
| topic | Bizarre parosteal osteochondromatous proliferation Cartilaginous tumor Periostitis Nora lesion Osteochondroma |
| url | https://doi.org/10.1186/s13244-023-01455-0 |
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