Ultrasound Triggering of Liposomal Nanodrugs for Cancer Therapy: A Review
Efficient conventional chemotherapy is limited by its nonspecific nature, which causes severe systemic toxicity that can lead to patient discomfort and low therapeutic efficacy. The emergence of smart drug delivery systems (SDDSs) utilizing nanoparticles as drug nanocarriers has shown great potentia...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Nanomaterials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-4991/12/17/3051 |
| _version_ | 1797493945690750976 |
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| author | Wafa N. Bahutair Waad H. Abuwatfa Ghaleb A. Husseini |
| author_facet | Wafa N. Bahutair Waad H. Abuwatfa Ghaleb A. Husseini |
| author_sort | Wafa N. Bahutair |
| collection | DOAJ |
| description | Efficient conventional chemotherapy is limited by its nonspecific nature, which causes severe systemic toxicity that can lead to patient discomfort and low therapeutic efficacy. The emergence of smart drug delivery systems (SDDSs) utilizing nanoparticles as drug nanocarriers has shown great potential in enhancing the targetability of anticancer agents and limiting their side effects. Liposomes are among the most investigated nanoplatforms due to their promising capabilities of encapsulating hydrophilic, lipophilic, and amphiphilic drugs, biocompatibility, physicochemical and biophysical properties. Liposomal nanodrug systems have demonstrated the ability to alter drugs’ biodistribution by sufficiently delivering the entrapped chemotherapeutics at the targeted diseased sites, sparing normal cells from undesired cytotoxic effects. Combining liposomal treatments with ultrasound, as an external drug release triggering modality, has been proven effective in spatially and temporally controlling and stimulating drug release. Therefore, this paper reviews recent literature pertaining to the therapeutic synergy of triggering nanodrugs from liposomes using ultrasound. It also highlights the effects of multiple physical and chemical factors on liposomes’ sonosensetivity, several ultrasound-induced drug release mechanisms, and the efficacy of ultrasound-responsive liposomal systems in cancer therapy. Overall, liposomal nanodrug systems triggered by ultrasound are promising cancer therapy platforms that can potentially alleviate the detriments of conventional cancer treatments. |
| first_indexed | 2024-03-10T01:27:16Z |
| format | Article |
| id | doaj.art-e6bd51c2289b4e1a97d8c7602b99f4c9 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T01:27:16Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-e6bd51c2289b4e1a97d8c7602b99f4c92023-11-23T13:50:03ZengMDPI AGNanomaterials2079-49912022-09-011217305110.3390/nano12173051Ultrasound Triggering of Liposomal Nanodrugs for Cancer Therapy: A ReviewWafa N. Bahutair0Waad H. Abuwatfa1Ghaleb A. Husseini2Department of Chemical Engineering, College of Engineering, American University of Sharjah, Sharjah P.O. Box. 26666, United Arab EmiratesDepartment of Chemical Engineering, College of Engineering, American University of Sharjah, Sharjah P.O. Box. 26666, United Arab EmiratesDepartment of Chemical Engineering, College of Engineering, American University of Sharjah, Sharjah P.O. Box. 26666, United Arab EmiratesEfficient conventional chemotherapy is limited by its nonspecific nature, which causes severe systemic toxicity that can lead to patient discomfort and low therapeutic efficacy. The emergence of smart drug delivery systems (SDDSs) utilizing nanoparticles as drug nanocarriers has shown great potential in enhancing the targetability of anticancer agents and limiting their side effects. Liposomes are among the most investigated nanoplatforms due to their promising capabilities of encapsulating hydrophilic, lipophilic, and amphiphilic drugs, biocompatibility, physicochemical and biophysical properties. Liposomal nanodrug systems have demonstrated the ability to alter drugs’ biodistribution by sufficiently delivering the entrapped chemotherapeutics at the targeted diseased sites, sparing normal cells from undesired cytotoxic effects. Combining liposomal treatments with ultrasound, as an external drug release triggering modality, has been proven effective in spatially and temporally controlling and stimulating drug release. Therefore, this paper reviews recent literature pertaining to the therapeutic synergy of triggering nanodrugs from liposomes using ultrasound. It also highlights the effects of multiple physical and chemical factors on liposomes’ sonosensetivity, several ultrasound-induced drug release mechanisms, and the efficacy of ultrasound-responsive liposomal systems in cancer therapy. Overall, liposomal nanodrug systems triggered by ultrasound are promising cancer therapy platforms that can potentially alleviate the detriments of conventional cancer treatments.https://www.mdpi.com/2079-4991/12/17/3051liposomespassive targetingactive targetingreceptor-mediated endocytosisultrasoundtriggered release |
| spellingShingle | Wafa N. Bahutair Waad H. Abuwatfa Ghaleb A. Husseini Ultrasound Triggering of Liposomal Nanodrugs for Cancer Therapy: A Review Nanomaterials liposomes passive targeting active targeting receptor-mediated endocytosis ultrasound triggered release |
| title | Ultrasound Triggering of Liposomal Nanodrugs for Cancer Therapy: A Review |
| title_full | Ultrasound Triggering of Liposomal Nanodrugs for Cancer Therapy: A Review |
| title_fullStr | Ultrasound Triggering of Liposomal Nanodrugs for Cancer Therapy: A Review |
| title_full_unstemmed | Ultrasound Triggering of Liposomal Nanodrugs for Cancer Therapy: A Review |
| title_short | Ultrasound Triggering of Liposomal Nanodrugs for Cancer Therapy: A Review |
| title_sort | ultrasound triggering of liposomal nanodrugs for cancer therapy a review |
| topic | liposomes passive targeting active targeting receptor-mediated endocytosis ultrasound triggered release |
| url | https://www.mdpi.com/2079-4991/12/17/3051 |
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